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Hormones travel through the blood stream and bind to receptors located on target cells. Which of the following would NOT bind to transmembrane proteins on the target cells?
  • a)
    Estrogen
  • b)
    Prolactin
  • c)
    Insulin
  • d)
    Antidiuretic Hormone
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
Hormones travel through the blood stream and bind to receptors located...
Peptide hormones, with the exception of tyrosine, are generally hydrophilic.
Hydrophilic molecules do not have favorable interactions with the hydrophobic fatty acid tails within the phospholipid bilayer and therefore do not readily diffuse across the membrane.
Estrogen is a hydrophobic steroid hormone and readily diffuses across the cell membrane and binds to receptors located inside the cell. It does not bind to transmembrane proteins located on the surface of the cell and is the correct answer.
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Most Upvoted Answer
Hormones travel through the blood stream and bind to receptors located...
Explanation:

Estrogen:
Estrogen is a hormone that binds to intracellular receptors, not transmembrane proteins. Once estrogen enters the target cell, it binds to its receptor in the cytoplasm or nucleus, forming a hormone-receptor complex that then enters the nucleus to regulate gene expression.

Prolactin:
Prolactin binds to transmembrane receptors on target cells, initiating a signaling cascade that can have various physiological effects, such as milk production in mammary glands.

Insulin:
Insulin binds to transmembrane receptors on target cells, specifically insulin receptors located on the cell surface. This binding activates a series of intracellular signaling pathways that regulate glucose uptake and metabolism.

Antidiuretic Hormone (ADH):
ADH, also known as vasopressin, binds to transmembrane receptors on target cells in the kidneys to regulate water reabsorption. This binding activates a signaling pathway that increases water permeability in the collecting ducts of the kidneys.
In summary, estrogen is the hormone that does not bind to transmembrane proteins on target cells, as it acts via intracellular receptors. Prolactin, insulin, and ADH all bind to transmembrane receptors to exert their physiological effects.
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