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Which of the following organelles plays a key role in apoptosis (programmed cell death)?
- a)mitochondrion
- b)lysozome
- c)endoplasmic reticulum
- d)golgi apparatus
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
Which of the following organelles plays a key role in apoptosis (progr...
The mitochondrion is known to have a significant role in apoptosis. It is involved in the intrinsic pathway of apoptosis, which is activated by various stimuli such as DNA damage or cellular stress. During apoptosis, mitochondria release proteins, such as cytochrome c, into the cytoplasm, which triggers a cascade of events leading to cell death. These released proteins activate caspases, enzymes responsible for dismantling the cell and executing the apoptotic process. The mitochondrion is also involved in regulating the balance between pro-apoptotic and anti-apoptotic proteins, influencing the cell's fate in terms of survival or death.
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Which of the following organelles plays a key role in apoptosis (progr...
Role of Mitochondrion in Apoptosis
Mitochondria play a crucial role in apoptosis, or programmed cell death. Here's how:
- Release of Cytochrome c: During apoptosis, the mitochondria release proteins such as cytochrome c into the cytoplasm. Cytochrome c then activates caspases, which are enzymes that play a key role in the cell death process.
- Regulation of Cell Death Pathways: Mitochondria also regulate various cell death pathways by releasing pro-apoptotic factors like cytochrome c and apoptosis-inducing factors. This leads to the activation of caspases and ultimately cell death.
- Generation of Reactive Oxygen Species (ROS): Mitochondria are a major source of reactive oxygen species (ROS) in cells. Excessive ROS production can cause oxidative damage to cellular components and trigger apoptosis.
- Regulation of Calcium Levels: Mitochondria are involved in regulating intracellular calcium levels. Dysregulation of calcium homeostasis can lead to mitochondrial dysfunction and apoptosis.
In summary, the mitochondrion plays a central role in apoptosis by releasing key proteins, regulating cell death pathways, generating ROS, and maintaining calcium homeostasis within the cell.
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Which of the following organelles plays a key role in apoptosis (programmed cell death)?a)mitochondrionb)lysozomec)endoplasmic reticulumd)golgi apparatusCorrect answer is option 'A'. Can you explain this answer? for MCAT 2025 is part of MCAT preparation. The Question and answers have been prepared according to the MCAT exam syllabus. Information about Which of the following organelles plays a key role in apoptosis (programmed cell death)?a)mitochondrionb)lysozomec)endoplasmic reticulumd)golgi apparatusCorrect answer is option 'A'. Can you explain this answer? covers all topics & solutions for MCAT 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which of the following organelles plays a key role in apoptosis (programmed cell death)?a)mitochondrionb)lysozomec)endoplasmic reticulumd)golgi apparatusCorrect answer is option 'A'. Can you explain this answer?.
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