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Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?
  • a)
    Loss of functional RB and CDK that does not respond to negative feedback
  • b)
    No RB mutation and CDK that does not respond to negative feedback
  • c)
    Loss of functional RB and no CDK mutation
  • d)
    No RB mutation and CDK that cannot bind to cyclin
Correct answer is option 'D'. Can you explain this answer?
Verified Answer
Retinoblastoma protein, RB, is an important cell cycle checkpoint prot...
In option D, there is no RB mutation, meaning that the RB protein is intact and able to properly inhibit the cell cycle progression. Additionally, the CDK in this scenario cannot bind to cyclin. Without the formation of the cyclin/CDK complex, CDK activity is inhibited, preventing uncontrolled cell cycle progression. This scenario, where RB is functional and CDK cannot bind to cyclin, is less likely to lead to the formation of a neoplasm compared to the other options.
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Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer? for MCAT 2025 is part of MCAT preparation. The Question and answers have been prepared according to the MCAT exam syllabus. Information about Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer? covers all topics & solutions for MCAT 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer?.
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Here you can find the meaning of Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer? defined & explained in the simplest way possible. Besides giving the explanation of Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer?, a detailed solution for Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer? has been provided alongside types of Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer? theory, EduRev gives you an ample number of questions to practice Retinoblastoma protein, RB, is an important cell cycle checkpoint protein that prevents the transition from G1 to S phase. The presence of the cyclin/CDK complex releases it from the genes that it binds. Which of the following mutation scenarios is least likely to lead to the formation of a neoplasm?a)Loss of functional RB and CDK that does not respond to negative feedbackb)No RB mutation and CDK that does not respond to negative feedbackc)Loss of functional RB and no CDK mutationd)No RB mutation and CDK that cannot bind to cyclinCorrect answer is option 'D'. Can you explain this answer? tests, examples and also practice MCAT tests.
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