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At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:
- a)SPR ( scaffold protein region)
- b)MAR (matrix associated region)
- c)NAR (nuclear associated regions )
- d)HAR (histone associated regions)
Correct answer is option 'B'. Can you explain this answer?
Verified Answer
At interphase, histone-bound chromosomes are attached to the nuclear w...
Concept:
- DNA components called scaffold/matrix attachment regions (S/MARs) are used to divide chromatin into structural and functional domains.
- These components play a part in disease biology as well as the regulation of gene expression, which determines phenotype.
- Therefore, understanding these components at the genomic scale offers significant therapeutic potential.
- There have been numerous attempts to identify S/MARs in the genomes of different creatures, including the human.
- But there isn't yet a complete genome-wide atlas of human S/MARs.
Explanation:
- A three-dimensional filamentous RNA-protein meshwork called the nuclear matrix serves as the structural backbone for the orderly compaction of DNA .
- Due to DNA sequences that connect the chromatin to the nuclear matrix, the chromatin is arranged into loops.
- The term "scaffold/matrix attachment regions" (S/MARs) refers to these anchor sequences.
- S/MARs are known to interact with a variety of proteins, known as S/MAR binding proteins (S/MARBPs), to promote chromatin looping.
- Numerous biological functions, including DNA replication, transcription, chromatin to chromosomal transition, and DNA repair, have been shown to depend on such DNA looping.
- Interestingly, there is no sequence conservation in the S/MARs that attach these loops to the nuclear matrix.
- Nevertheless, characteristics of its secondary structure seem to remain preserved and functionally significant.
Fig 1: MARs
Option 1:
SPR ( scaffold protein regio
n)- Consider the explanation above thus this option is not true
Option 2:
MAR (matrix associated region)
- Consider the explanation above thus this option is true.
Option 3:
NAR (nuclear associated regions )
- Consider the explanation above thus this option is not true
Option 4:
HAR (histone associated regions)
- Consider the explanation above thus this option is not true
hence the correct answer is option 1
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At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:a)SPR ( scaffold protein region)b)MAR (matrix associated region)c)NAR (nuclear associated regions )d)HAR (histone associated regions)Correct answer is option 'B'. Can you explain this answer?
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At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:a)SPR ( scaffold protein region)b)MAR (matrix associated region)c)NAR (nuclear associated regions )d)HAR (histone associated regions)Correct answer is option 'B'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:a)SPR ( scaffold protein region)b)MAR (matrix associated region)c)NAR (nuclear associated regions )d)HAR (histone associated regions)Correct answer is option 'B'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:a)SPR ( scaffold protein region)b)MAR (matrix associated region)c)NAR (nuclear associated regions )d)HAR (histone associated regions)Correct answer is option 'B'. Can you explain this answer?.
At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:a)SPR ( scaffold protein region)b)MAR (matrix associated region)c)NAR (nuclear associated regions )d)HAR (histone associated regions)Correct answer is option 'B'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:a)SPR ( scaffold protein region)b)MAR (matrix associated region)c)NAR (nuclear associated regions )d)HAR (histone associated regions)Correct answer is option 'B'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for At interphase, histone-bound chromosomes are attached to the nuclear wall via lamin and are called:a)SPR ( scaffold protein region)b)MAR (matrix associated region)c)NAR (nuclear associated regions )d)HAR (histone associated regions)Correct answer is option 'B'. Can you explain this answer?.
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