Reduction of alkanenitriles with sodium and alcohol or LiAlH4is called:a)Wolf-Kishner reductionb)Rosenmund reductionc)Mendius reactiond)Catalytic reductionCorrect answer is option 'C'. Can you explain this answer?

Question

Answer

The reaction is a Mendius reaction as because in this reaction the organic nitrile is reduced by nascent hydrogen(from sodium in ethanol) to a primary amine. (RCN+2H2=RCH2NH2).
where as LiAlH4 is a strong reducing agent and can be used as an abstract source of H neucophile.

Answer

The answer is mendius reaction because in this specific reaction..the reducing agent is Na and LiAlH4...

Answer

Yes it is correct because reduction of alkanenitrile in presence of NA IN C2H5 is called mendius reaction

Answer

The reaction is a Mendius reaction as because in this reaction the organic nitrile is reduced by nascent hydrogen(from sodium in ethanol) to a primary amine. (RCN+2H2=RCH2NH2).
where as LiAlH4 is a strong reducing agent and can be used as an abstract source of H neucophile.

Answer

Reduction of Alkanenitriles with Sodium and Alcohol or LiAlH4

The reduction of alkanenitriles with sodium and alcohol or LiAlH4 is known as the Mendius reaction. This reaction is commonly used to convert alkanenitriles into primary amines.

The Mendius Reaction:
The Mendius reaction involves the reduction of alkanenitriles (RCN) to primary amines (RCH2NH2) using sodium (Na) and alcohol (ROH) or lithium aluminum hydride (LiAlH4). The reaction proceeds through the following steps:

1. Formation of the imine:
- The alkanenitrile reacts with sodium in the presence of alcohol to form an imine intermediate.
- The sodium donates an electron to the nitrile group, resulting in the formation of a negatively charged carbon atom.

2. Reduction of the imine:
- The imine intermediate is then reduced by either sodium and alcohol or LiAlH4.
- In the presence of sodium and alcohol, the imine is reduced to a primary amine through nucleophilic attack by the alcohol.

3. Formation of the primary amine:
- The reduced imine reacts with another molecule of sodium and alcohol or LiAlH4 to yield the primary amine.
- In the case of sodium and alcohol, the alcohol donates a proton to the nitrogen atom of the imine, resulting in the formation of the primary amine.
- When LiAlH4 is used, it acts as a strong reducing agent, directly reducing the imine to the primary amine.

Applications:
The Mendius reaction is widely used in organic synthesis for the preparation of primary amines. Primary amines are versatile compounds that find applications in pharmaceuticals, agrochemicals, dyes, and many other industries. Some specific applications of the Mendius reaction include:

1. Synthesis of pharmaceuticals:
- The reduction of alkanenitriles to primary amines provides a valuable route for the synthesis of various pharmaceuticals.
- Primary amines are key building blocks in the synthesis of many drugs and pharmaceutical intermediates.

2. Preparation of agrochemicals:
- Primary amines are important intermediates in the synthesis of agrochemicals such as herbicides, insecticides, and fungicides.
- The Mendius reaction enables the efficient conversion of alkanenitriles to primary amines, which can be further transformed into agrochemicals.

3. Production of dyes:
- Primary amines are used in the production of dyes and pigments.
- The Mendius reaction provides a convenient method to obtain primary amines that can be further modified to yield various dyes.

In summary, the reduction of alkanenitriles with sodium and alcohol or LiAlH4, known as the Mendius reaction, is a valuable method for the synthesis of primary amines. This reaction has significant applications in the pharmaceutical, agrochemical, and dye industries.

Top Courses for Class 12View all

English Class 12

Chemistry Class 12

Physics Class 12

English Flamingo Class 12

Physical Education Class 12(XII) - Notes & Model Test Papers

Top Courses for Class 12

Top Courses for Class 12

Related Content

Schools

Competitive Examinations

Quick Access Links

Technical Exams