Class 12 Exam > Class 12 Questions > When Primary amide is treated with an aqueous...
Start Learning for Free
When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:
- a)Gabriel-phthalamine reaction
- b)Reimer-Tiemann reaction
- c)Ammonolysis
- d)Hoffmann Bromamide reaction
Correct answer is option 'D'. Can you explain this answer?
| FREE This question is part of | Download PDF Attempt this Test |
Verified Answer
When Primary amide is treated with an aqueous solution of KOH and brom...
Hoffmann Bromamide reaction is Treatment of alkylamide with KOH and Bromine gas which converts it into alkylamine with one less carbon atom, this reaction is generally helpful in converting Carboxylic acids to amines with one less carbon atom . For reaction you may refer to internet but i can give you a hint .
Acetamide + KOH + Bromine gas —-> Alkylamine+ KBr + K2CO3 + H20 ( not sure about the products)
Most Upvoted Answer
When Primary amide is treated with an aqueous solution of KOH and brom...
Answer:
Hoffmann Bromamide Reaction:
The reaction in question is the Hoffmann Bromamide reaction, which involves the conversion of a primary amide to a primary amine using an aqueous solution of KOH and bromine. This reaction is named after its discoverer, August Wilhelm von Hofmann.
Reaction Mechanism:
The reaction proceeds through a series of steps:
1. Bromination:
The primary amide reacts with bromine to form an N-bromoamide intermediate. This step involves the addition of bromine across the double bond of the amide group.
2. Hydrolysis:
The N-bromoamide intermediate is then treated with an aqueous solution of KOH, which results in the hydrolysis of the amide group. The bromine atom is replaced by a hydroxyl group (OH-), forming an N-hydroxyamide intermediate.
3. Rearrangement:
The N-hydroxyamide intermediate undergoes rearrangement, leading to the formation of an isocyanate intermediate. This rearrangement involves the migration of an alkyl or aryl group from the nitrogen atom to the carbon atom of the carbonyl group.
4. Hydrolysis:
The isocyanate intermediate is then hydrolyzed by the aqueous KOH solution, resulting in the formation of a primary amine. The hydroxyl group is replaced by an amino group (NH2-).
Significance:
The Hoffmann Bromamide reaction is an important method for the synthesis of primary amines from primary amides. It provides a mild and efficient way to convert amides to amines, which are versatile building blocks in organic synthesis.
Other Options:
a) Gabriel-Phthalamine Reaction:
The Gabriel-Phthalamine reaction is a different reaction that involves the synthesis of primary amines from phthalimide derivatives. It is not relevant to the given reaction.
b) Reimer-Tiemann Reaction:
The Reimer-Tiemann reaction involves the conversion of phenols to salicylaldehydes using chloroform and a strong base. It is not relevant to the given reaction.
c) Ammonolysis:
Ammonolysis refers to the reaction of an organic compound with ammonia or an amine to form an amide. It is not relevant to the given reaction.
Hoffmann Bromamide Reaction:
The reaction in question is the Hoffmann Bromamide reaction, which involves the conversion of a primary amide to a primary amine using an aqueous solution of KOH and bromine. This reaction is named after its discoverer, August Wilhelm von Hofmann.
Reaction Mechanism:
The reaction proceeds through a series of steps:
1. Bromination:
The primary amide reacts with bromine to form an N-bromoamide intermediate. This step involves the addition of bromine across the double bond of the amide group.
2. Hydrolysis:
The N-bromoamide intermediate is then treated with an aqueous solution of KOH, which results in the hydrolysis of the amide group. The bromine atom is replaced by a hydroxyl group (OH-), forming an N-hydroxyamide intermediate.
3. Rearrangement:
The N-hydroxyamide intermediate undergoes rearrangement, leading to the formation of an isocyanate intermediate. This rearrangement involves the migration of an alkyl or aryl group from the nitrogen atom to the carbon atom of the carbonyl group.
4. Hydrolysis:
The isocyanate intermediate is then hydrolyzed by the aqueous KOH solution, resulting in the formation of a primary amine. The hydroxyl group is replaced by an amino group (NH2-).
Significance:
The Hoffmann Bromamide reaction is an important method for the synthesis of primary amines from primary amides. It provides a mild and efficient way to convert amides to amines, which are versatile building blocks in organic synthesis.
Other Options:
a) Gabriel-Phthalamine Reaction:
The Gabriel-Phthalamine reaction is a different reaction that involves the synthesis of primary amines from phthalimide derivatives. It is not relevant to the given reaction.
b) Reimer-Tiemann Reaction:
The Reimer-Tiemann reaction involves the conversion of phenols to salicylaldehydes using chloroform and a strong base. It is not relevant to the given reaction.
c) Ammonolysis:
Ammonolysis refers to the reaction of an organic compound with ammonia or an amine to form an amide. It is not relevant to the given reaction.
Free Test
FREE
| Start Free Test |
Community Answer
When Primary amide is treated with an aqueous solution of KOH and brom...
Hoffmann Bromamide reaction is Treatment of alkylamide with KOH and Bromine gas which converts it into alkylamine with one less carbon atom, this reaction is generally helpful in converting Carboxylic acids to amines with one less carbon atom . For reaction you may refer to internet but i can give you a hint .
Acetamide + KOH + Bromine gas —-> Alkylamine+ KBr + K2CO3 + H20 ( not sure about the products)
|
Explore Courses for Class 12 exam
|
|
When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer?
Question Description
When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? for Class 12 2024 is part of Class 12 preparation. The Question and answers have been prepared according to the Class 12 exam syllabus. Information about When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? covers all topics & solutions for Class 12 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer?.
When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? for Class 12 2024 is part of Class 12 preparation. The Question and answers have been prepared according to the Class 12 exam syllabus. Information about When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? covers all topics & solutions for Class 12 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer?.
Solutions for When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? in English & in Hindi are available as part of our courses for Class 12.
Download more important topics, notes, lectures and mock test series for Class 12 Exam by signing up for free.
Here you can find the meaning of When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? defined & explained in the simplest way possible. Besides giving the explanation of
When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer?, a detailed solution for When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? has been provided alongside types of When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? theory, EduRev gives you an
ample number of questions to practice When Primary amide is treated with an aqueous solution of KOH and bromine, it gives a primary amine. The name of the reaction is:a)Gabriel-phthalamine reactionb)Reimer-Tiemann reactionc)Ammonolysisd)Hoffmann Bromamide reactionCorrect answer is option 'D'. Can you explain this answer? tests, examples and also practice Class 12 tests.
|
|
Explore Courses for Class 12 exam
|
|
Signup for Free!
Signup to see your scores go up within 7 days! Learn & Practice with 1000+ FREE Notes, Videos & Tests.
|
© EduRev
|
Education Revolution
|
Follow Us
|
Signup to see your scores
go up within 7 days!
Access 1000+ FREE Docs, Videos and Tests
Takes less than 10 seconds to signup