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Which of the following metals is present at the active site of carbonic anhydrase enzyme?
- a)Iron (Fe)
- b)Zinc (Zn)
- c)Copper (Cu)
- d)e)b) Zinc (Zn)c) Copper (Cu)
Correct answer is option 'B'. Can you explain this answer?
Most Upvoted Answer
Which of the following metals is present at the active site of carboni...
Active Site of Carbonic Anhydrase
Carbonic anhydrase is a crucial enzyme that catalyzes the reversible reaction between carbon dioxide and water to form bicarbonate and protons. The presence of a metal ion at its active site is essential for its enzymatic function.
Metal Ion in Carbonic Anhydrase
- The active site of carbonic anhydrase contains Zinc (Zn).
- Zinc plays a vital role in facilitating the reaction by stabilizing the negative charge that develops during the conversion of carbon dioxide and water.
Function of Zinc in the Enzyme
- Catalytic Role: Zinc has a strong affinity for water molecules, which helps in the conversion of carbon dioxide into bicarbonate.
- Hydration: The presence of zinc allows water molecules to be more nucleophilic, enhancing the reaction rate.
Comparison with Other Metals
- Iron (Fe): While iron is important in many biological processes, it is not involved in carbonic anhydrase activity.
- Copper (Cu): Copper also has enzymatic roles, but it does not participate in the active site of carbonic anhydrase.
Conclusion
In summary, the correct answer is Zinc (Zn) due to its critical role at the active site of carbonic anhydrase, enabling efficient catalysis of the carbon dioxide hydration reaction. This unique feature highlights the importance of metal ions in enzymatic functions.
Carbonic anhydrase is a crucial enzyme that catalyzes the reversible reaction between carbon dioxide and water to form bicarbonate and protons. The presence of a metal ion at its active site is essential for its enzymatic function.
Metal Ion in Carbonic Anhydrase
- The active site of carbonic anhydrase contains Zinc (Zn).
- Zinc plays a vital role in facilitating the reaction by stabilizing the negative charge that develops during the conversion of carbon dioxide and water.
Function of Zinc in the Enzyme
- Catalytic Role: Zinc has a strong affinity for water molecules, which helps in the conversion of carbon dioxide into bicarbonate.
- Hydration: The presence of zinc allows water molecules to be more nucleophilic, enhancing the reaction rate.
Comparison with Other Metals
- Iron (Fe): While iron is important in many biological processes, it is not involved in carbonic anhydrase activity.
- Copper (Cu): Copper also has enzymatic roles, but it does not participate in the active site of carbonic anhydrase.
Conclusion
In summary, the correct answer is Zinc (Zn) due to its critical role at the active site of carbonic anhydrase, enabling efficient catalysis of the carbon dioxide hydration reaction. This unique feature highlights the importance of metal ions in enzymatic functions.
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Community Answer
Which of the following metals is present at the active site of carboni...
b) Zinc (Zn)
- Carbonic anhydrase is a zinc-containing metalloenzyme.
- Zinc plays a crucial role in catalyzing the reversible hydration of carbon dioxide to bicarbonate and proton.
- This reaction is essential for maintaining acid-base balance in blood and tissues.
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