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In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :
Normal : AGGGCATTAGC
Mutant : AGGGCTTTGC
Normal : AGGGCATTAGC
Mutant : AGGGCTTTGC
Which of the following processes in this mutation most likely to affect ?
- a)Frame Shift Mutation
- b)Capping
- c)Splicing
- d)Hybridization
Correct answer is option 'C'. Can you explain this answer?
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Most Upvoted Answer
In a Eukaryotic gene. One of the introns is mutated at the 3’ en...
Explanation:
Splicing is the process involved in removing introns from pre-mRNA and joining the exons together to form mature mRNA. The mutation in the intron at the 3' end of a eukaryotic gene can affect the splicing process.
Effects of Mutation on Splicing:
The effect of a mutation on splicing depends on the location of the mutation in the intron. Mutations at the splice site (exon-intron junction) can affect the recognition of the splice site by the spliceosome, which may lead to exon skipping or intron retention. Mutations within the intron can also affect splicing by creating new splice sites or disrupting existing ones.
In the given mutation, the nucleotide sequence at the 3' end of the intron has changed from TAGC to TTGC. This change creates a new potential splice site (AGG GCT TTA GC) within the intron. The spliceosome may recognize this new site and use it instead of the normal splice site, which can lead to the retention of a part of the intron or the inclusion of a part of the exon in the mature mRNA.
Conclusion:
Therefore, the mutation in the intron at the 3' end of a eukaryotic gene is most likely to affect the splicing process. The mutation can create new splice sites or disrupt existing ones, leading to abnormal splicing and the production of aberrant mRNA.
Splicing is the process involved in removing introns from pre-mRNA and joining the exons together to form mature mRNA. The mutation in the intron at the 3' end of a eukaryotic gene can affect the splicing process.
Effects of Mutation on Splicing:
The effect of a mutation on splicing depends on the location of the mutation in the intron. Mutations at the splice site (exon-intron junction) can affect the recognition of the splice site by the spliceosome, which may lead to exon skipping or intron retention. Mutations within the intron can also affect splicing by creating new splice sites or disrupting existing ones.
In the given mutation, the nucleotide sequence at the 3' end of the intron has changed from TAGC to TTGC. This change creates a new potential splice site (AGG GCT TTA GC) within the intron. The spliceosome may recognize this new site and use it instead of the normal splice site, which can lead to the retention of a part of the intron or the inclusion of a part of the exon in the mature mRNA.
Conclusion:
Therefore, the mutation in the intron at the 3' end of a eukaryotic gene is most likely to affect the splicing process. The mutation can create new splice sites or disrupt existing ones, leading to abnormal splicing and the production of aberrant mRNA.
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Community Answer
In a Eukaryotic gene. One of the introns is mutated at the 3’ en...
Splicing is affected bcoz sequence of the strand is changed and enzyme will not get its original sequence to remove the introns i. e. enzyme will not identify which sequence is exons and which sequence is introns.
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In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :Normal : AGGGCATTAGCMutant : AGGGCTTTGCWhich of the following processes in this mutation most likely to affect ?a)Frame Shift Mutationb)Cappingc)Splicingd)HybridizationCorrect answer is option 'C'. Can you explain this answer?
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In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :Normal : AGGGCATTAGCMutant : AGGGCTTTGCWhich of the following processes in this mutation most likely to affect ?a)Frame Shift Mutationb)Cappingc)Splicingd)HybridizationCorrect answer is option 'C'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :Normal : AGGGCATTAGCMutant : AGGGCTTTGCWhich of the following processes in this mutation most likely to affect ?a)Frame Shift Mutationb)Cappingc)Splicingd)HybridizationCorrect answer is option 'C'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :Normal : AGGGCATTAGCMutant : AGGGCTTTGCWhich of the following processes in this mutation most likely to affect ?a)Frame Shift Mutationb)Cappingc)Splicingd)HybridizationCorrect answer is option 'C'. Can you explain this answer?.
In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :Normal : AGGGCATTAGCMutant : AGGGCTTTGCWhich of the following processes in this mutation most likely to affect ?a)Frame Shift Mutationb)Cappingc)Splicingd)HybridizationCorrect answer is option 'C'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :Normal : AGGGCATTAGCMutant : AGGGCTTTGCWhich of the following processes in this mutation most likely to affect ?a)Frame Shift Mutationb)Cappingc)Splicingd)HybridizationCorrect answer is option 'C'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for In a Eukaryotic gene. One of the introns is mutated at the 3’ end as shown :Normal : AGGGCATTAGCMutant : AGGGCTTTGCWhich of the following processes in this mutation most likely to affect ?a)Frame Shift Mutationb)Cappingc)Splicingd)HybridizationCorrect answer is option 'C'. Can you explain this answer?.
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