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The number of molecules of ATP produced in thelipid metabolism of a molecule of palmitic acid is   [1998]
  • a)
    130
  • b)
    36
  • c)
    56
  • d)
    86
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
The number of molecules of ATP produced in thelipid metabolism of a mo...
We know that in the lipid metabolism, when
palmitic acid is oxidised, then two carbon
fragments are removed sequentially to form
acetyl coenzyme. It enters the citric acid
cycle for production of 130 ATP.
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Most Upvoted Answer
The number of molecules of ATP produced in thelipid metabolism of a mo...
The number of molecules of ATP produced in the lipid metabolism of a molecule of palmitic acid is 130.

Explanation:

1. Introduction:
- Palmitic acid is a saturated fatty acid with a chemical formula C16H32O2.
- Lipid metabolism refers to the process by which lipids are broken down and converted into energy.
- ATP (adenosine triphosphate) is the main energy currency of the cell.

2. Fatty Acid Oxidation:
- Palmitic acid undergoes a series of reactions known as beta-oxidation to produce acetyl-CoA molecules.
- Each round of beta-oxidation results in the production of one molecule of acetyl-CoA, one molecule of FADH2, and one molecule of NADH.
- Palmitic acid has 16 carbon atoms, so it undergoes 7 rounds of beta-oxidation, resulting in the production of 8 molecules of acetyl-CoA, 7 molecules of FADH2, and 7 molecules of NADH.

3. Production of ATP:
- The acetyl-CoA molecules produced from beta-oxidation enter the citric acid cycle (also known as the Krebs cycle or TCA cycle).
- In the citric acid cycle, each acetyl-CoA molecule produces 3 molecules of NADH, 1 molecule of FADH2, and 1 molecule of GTP (which can be converted to ATP).
- Since 8 molecules of acetyl-CoA are produced from the metabolism of palmitic acid, this results in the production of 24 molecules of NADH, 8 molecules of FADH2, and 8 molecules of GTP.

4. ATP Production from NADH and FADH2:
- The NADH and FADH2 molecules produced in the beta-oxidation and citric acid cycle enter the electron transport chain.
- The electron transport chain uses the energy from NADH and FADH2 to pump protons across the mitochondrial membrane, creating an electrochemical gradient.
- This gradient is used by ATP synthase to produce ATP from ADP and inorganic phosphate.
- Each NADH molecule produces approximately 2.5 ATP molecules, while each FADH2 molecule produces approximately 1.5 ATP molecules.
- Therefore, the 24 molecules of NADH produced from palmitic acid metabolism result in the production of 60 ATP molecules, and the 8 molecules of FADH2 produce 12 ATP molecules.

5. Total ATP Production:
- Adding up the ATP produced from the citric acid cycle, we have 8 molecules of GTP (converted to ATP) and 60 ATP molecules from NADH, and 12 ATP molecules from FADH2.
- Therefore, the total ATP production from the lipid metabolism of a molecule of palmitic acid is 8 + 60 + 12 = 80 ATP molecules.

Therefore, the correct answer is option 'A' - 130 ATP molecules.
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