**What happens when Endoplasmic Reticulum is removed from a cell?**

The Endoplasmic Reticulum (ER) is an important organelle found in eukaryotic cells. It plays a crucial role in various cellular processes, such as protein synthesis, lipid metabolism, and calcium storage. Removing the ER from a cell would have significant consequences on the cell's structure and function. Here is a detailed explanation of what happens when the ER is removed:

**Disruption of Protein Synthesis:**

One of the primary functions of the ER is protein synthesis. The rough ER, characterized by ribosomes attached to its surface, is responsible for the synthesis and processing of proteins. These proteins are then transported to different parts of the cell or secreted outside. Without the ER, the cell would lose its ability to synthesize proteins efficiently, leading to a disruption in various cellular processes.

**Impaired Lipid Metabolism:**

Another important function of the ER is lipid metabolism. The smooth ER, lacking ribosomes, is involved in the synthesis of lipids, including phospholipids and cholesterol. It also plays a role in detoxification reactions. Removal of the ER would hinder lipid synthesis and disrupt the cell's ability to produce and modify lipids, which are essential components of cell membranes.

**Calcium Homeostasis Disturbance:**

The ER acts as a calcium reservoir and helps in maintaining calcium homeostasis in the cell. Calcium ions are crucial for several cellular processes, including muscle contraction, signal transduction, and enzyme activation. The ER has calcium pumps and channels that regulate the concentration of calcium ions within the cell. If the ER is removed, the cell would lose its ability to maintain proper calcium levels, leading to disruptions in these essential processes.

**Altered Cell Morphology:**

The ER is an extensive network of tubules and flattened sacs that extends throughout the cytoplasm, giving the cell a distinct morphology. Removal of the ER would result in significant changes in the cell's shape and structure. The cell would lose its characteristic tubular and sheet-like structures and might appear more rounded or irregular in shape.

**Overall Cellular Dysfunction:**

Collectively, the removal of the ER would lead to severe cellular dysfunction. The cell would lose its ability to efficiently synthesize proteins, metabolize lipids, maintain calcium homeostasis, and maintain its distinctive morphology. This would ultimately result in impaired cell function and could potentially lead to cell death.

ER is one of the important organelle in cell . If it will not remain then the cell will die because the toxic substances in cell can not be detoxified