Humayun faced several difficulties after coming to the throne, which made his reign turbulent and unstable. Some of the major challenges that he faced are as follows:

1. Internal Rebellion
After Babur's death, Humayun had to face internal rebellion from his half-brothers Kamran, Askari, and Hindal, who all wanted to be the ruler of the empire. Kamran, who was the governor of Kabul, refused to acknowledge Humayun's supremacy and declared himself as the ruler of the province. This rebellion weakened Humayun's hold on his empire and posed a significant threat to his authority.

2. External Threats
Humayun was also faced with several external threats from his neighboring states. The ruler of Bahadur Shah of Gujarat, Sher Shah Suri, and the Sultan of Bengal, Nasiruddin Nasrat Shah, posed significant challenges to Humayun's supremacy. These rulers were aware of Humayun's weakened position due to internal rebellion and took advantage of it by attacking his empire.

3. Financial Instability
Humayun inherited an empire that was already facing financial instability due to the expensive military campaigns of his father, Babur. Moreover, the internal rebellion and external threats further drained the empire's resources, making it difficult for Humayun to finance his military campaigns and maintain his authority.

4. Lack of Administrative Experience
Humayun lacked administrative experience, and his reign was marked by inefficiency and corruption. He was more interested in poetry and art than in governance, leading to a lack of focus on administrative issues. This lack of governance skills made it difficult for Humayun to manage internal rebellion, external threats, and financial instability.

5. Poor Health
Humayun suffered from poor health, which made it difficult for him to take decisive actions to address the challenges facing his empire. He was addicted to opium and alcohol, which further weakened his health and impaired his judgment.

In conclusion, Humayun faced several challenges after coming to the throne, which made his reign turbulent and unstable. His lack of administrative experience, poor health, internal rebellion, external threats, and financial instability all contributed to the difficulties he faced during his reign.

The difficulties faced by Humayun after coming to the throne are as follows :

• Humayun had inherited and empty treasure.

• He had faced oppositions from his brothers, relatives, Afghans and Rajputs.

• He was addicted to opium.

• He lacked in military ability.

• He was defeated by Sher Shah Suri.