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order of reactivities of following towards nucleophilic substitution rxn:(plz wid reason) 1.acyl chloride 2.ester 3.acid anhydride 4.amide
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order of reactivities of following towards nucleophilic substitution r...
Order of Reactivities towards Nucleophilic Substitution Reactions

Nucleophilic substitution reactions involve the replacement of a leaving group with a nucleophile. The order of reactivities towards nucleophilic substitution reactions among acyl chloride, ester, acid anhydride, and amide can be explained based on the stability of the leaving group and the resonance stabilization of the carbonyl group.

1. Acyl chloride

Acyl chlorides are the most reactive towards nucleophilic substitution reactions among the given compounds due to the presence of a highly unstable and reactive chloride leaving group. The chloride ion is a good leaving group because it is highly electronegative and unstable, making it easier to be displaced by a nucleophile. Additionally, the resonance stabilization of the carbonyl group in acyl chlorides is weak due to the electron-withdrawing nature of the chlorine atom.

2. Acid anhydride

Acid anhydrides are less reactive than acyl chlorides towards nucleophilic substitution reactions because the leaving group is a less reactive carboxylate ion. The carboxylate ion is a weaker leaving group than the chloride ion because it is more stable and less polarizable. However, the resonance stabilization of the carbonyl group in acid anhydrides is stronger than that in acyl chlorides due to the presence of two carbonyl groups.

3. Ester

Esters are less reactive than acid anhydrides towards nucleophilic substitution reactions because the leaving group is an even less reactive alkoxide ion. The alkoxide ion is a weaker leaving group than the carboxylate ion because it is more stable and less polarizable. Moreover, the resonance stabilization of the carbonyl group in esters is weaker than that in acid anhydrides because there is only one carbonyl group.

4. Amide

Amides are the least reactive towards nucleophilic substitution reactions among the given compounds due to the presence of a highly stable and unreactive amide leaving group. The amide group is a very weak leaving group because it is highly stable and less polarizable. Furthermore, the resonance stabilization of the carbonyl group in amides is the strongest due to the presence of a nitrogen atom that can donate electron density to the carbonyl group.

In conclusion, the order of reactivities towards nucleophilic substitution reactions among acyl chloride, acid anhydride, ester, and amide is acyl chloride > acid anhydride > ester > amide.
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order of reactivities of following towards nucleophilic substitution r...
acid halides are the  most reactive towards nucleophiles followed by anhydrides,esters, and amides Carboxylate ions are essentially unreactive towards nucleophiles , since they possess no leaving group. ... Thus, chloride ion is a better leaving group than acetate ion.
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order of reactivities of following towards nucleophilic substitution rxn:(plz wid reason) 1.acyl chloride 2.ester 3.acid anhydride 4.amide
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