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With reference to the Harlequin Ichthyosis disorder, consider the following statements:
1. It is a rare genetic skin disorder to a newborn infant.
2. This disorder affects only male population.
Which of the statements given above is/are correct?
  • a)
    1 only
  • b)
    2 only
  • c)
    Both 1 and 2
  • d)
    Neither 1 nor 2
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
With reference to the Harlequin Ichthyosis disorder, consider the foll...
  • Harlequin Ichthyosis is a rare genetic skin disorder to a newborn infant. It’s a type of ichthyosis, which refers to a group of disorders that cause persistently dry, scaly skin all over the body. Hence, statement 1 is correct.
  • It is inherited in an autosomal recessive pattern.
  • It can be caused by changes (mutations) in the ABCA12 gene.
    • Newborn infants are covered with plates of thick skin that crack and split apart and can restrict breathing and eating.
    • Premature birth is typical, leaving the infants at risk for complications from early delivery.
  • Affected Population:
    • It affects males and females in equal numbers. Hence, statement 2 is not correct.
    • It affects approximately one in 5,00,000 persons.
    • There are around 250 such cases across the world.
  • Treatment:
    • A newborn with Harlequin ichthyosis requires neonatal intensive care, which may include spending time in a heated incubator with high humidity.
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With reference to the Harlequin Ichthyosis disorder, consider the following statements:1. It is a rare genetic skin disorder to a newborn infant.2. This disorder affects only male population.Which of the statements given above is/are correct?a)1 onlyb)2 onlyc)Both 1 and 2d)Neither 1 nor 2Correct answer is option 'A'. Can you explain this answer?
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