Breakdown of the number of questions from each subject in the GATE ME exam:

1. Engineering Mathematics:
- This subject is an integral part of the GATE ME exam as it covers fundamental mathematical concepts and their applications in engineering.
- The weightage of Engineering Mathematics in the GATE ME exam is around 15%.
- The questions in this subject mainly revolve around topics like linear algebra, calculus, differential equations, complex variables, probability, and statistics.
- Approximately 5 to 7 questions can be expected from Engineering Mathematics in the GATE ME exam.

2. Applied Mechanics and Design:
- Applied Mechanics and Design is another important subject in the GATE ME exam, accounting for about 20% of the total weightage.
- It includes topics such as engineering mechanics, strength of materials, theory of machines, vibrations, and design of machine elements.
- Around 8 to 10 questions can be expected from Applied Mechanics and Design in the GATE ME exam.

3. Fluid Mechanics and Thermal Sciences:
- Fluid Mechanics and Thermal Sciences is a significant subject in the GATE ME exam, constituting approximately 30% of the total weightage.
- It covers topics like fluid mechanics, heat transfer, thermodynamics, and applications of these concepts.
- Candidates can expect around 10 to 12 questions from Fluid Mechanics and Thermal Sciences in the GATE ME exam.

4. Materials, Manufacturing, and Industrial Engineering:
- This subject carries a weightage of about 20% in the GATE ME exam.
- It encompasses topics like engineering materials, manufacturing processes, industrial engineering, and operations research.
- Approximately 7 to 9 questions can be expected from Materials, Manufacturing, and Industrial Engineering in the GATE ME exam.

5. General Aptitude:
- General Aptitude is a common section in all GATE papers, including the ME exam.
- It carries a weightage of around 15%.
- This section evaluates the candidates' language and analytical skills.
- Approximately 10 questions are asked from General Aptitude in the GATE ME exam.

Conclusion:
The GATE ME exam consists of questions from various subjects, with different weightages assigned to each subject. Engineering Mathematics, Applied Mechanics and Design, Fluid Mechanics and Thermal Sciences, Materials, Manufacturing, and Industrial Engineering, and General Aptitude are the major subjects included in the GATE ME exam. Candidates must prepare comprehensively in each subject to perform well in the exam.