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Consider the following statements for deoxy-hemerythrin and deoxy-hemocyanin:
A. they are involved in O2 transport in biological systems
B. they contain two metal ions in their active site
C. active site metal centres are bridged by amino acid residues
D. they prefer to bind only one O2 per active site
The correct statements are
  • a)
    A, B and D 
  • b)
    A, C and D 
  • c)
    B, C and D 
  • d)
    A and C
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
Consider the following statements for deoxy-hemerythrin and deoxy-hemo...
  • The metalloprotein hemerythrin involves Fe in the +2 oxidation state. The uptake of O2 by hemerythrin involves the two-electron oxidation of the diferrous center to produce a hydroperoxide (OOH) complex.
  • The conformation of the hemerythrin subunit designated the hemerythrin fold, has four nearly parallel α-helical segments surrounding the pair of non-heme iron atoms, the oxygen binding site.
  • These iron atoms are linked to the protein through specific histidine and tyrosine side chains.
  • The active site structure for oxy-hemerythrin is: 
  • Hemocyanin is a copper-containing protein that is found in the blood of some mollusks and arthropods. It is involved in oxygen transport, much like hemoglobin in vertebrates. Hemocyanin has a complex structure consisting of subunits, and each subunit contains a copper ion.
  • The copper ions in hemocyanin form a dinuclear copper center, where the two copper ions are surrounded by histidine residues.
  • This copper center is responsible for the binding of oxygen molecules. When oxygen binds to hemocyanin, the copper ions are reduced from the cupric (Cu(II)) state to the cuprous (Cu(I)) state. This reduction is facilitated by the histidine residues that bridge the two copper ions.
  • The oxygen molecules are bound to the copper ions in a reversible manner, which means that oxygen can be released when needed. When oxygen is released, the copper ions are oxidized back to the cupric state.
  • Thus, both deoxyhemerythrin and deoxy hemocyanin are O2 transport protein in biological system.
  • Both contain two metal ion at active site and they bind only O2 per active site.
Hence, The correct statements are A, B and D.
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Most Upvoted Answer
Consider the following statements for deoxy-hemerythrin and deoxy-hemo...
Deoxy-hemerythrin and deoxy-hemocyanin


Statement Analysis:

Let's analyze each statement to determine its correctness.

Statement A: they are involved in O2 transport in biological systems
- This statement is correct. Both deoxy-hemerythrin and deoxy-hemocyanin are involved in the transport of oxygen in biological systems.

Statement B: they contain two metal ions in their active site
- This statement is incorrect. Deoxy-hemerythrin contains two iron ions in its active site, while deoxy-hemocyanin contains two copper ions in its active site. Therefore, this statement is only true for deoxy-hemerythrin, not for deoxy-hemocyanin.

Statement C: active site metal centers are bridged by amino acid residues
- This statement is correct. Both deoxy-hemerythrin and deoxy-hemocyanin have metal centers in their active sites that are bridged by amino acid residues. In deoxy-hemerythrin, the iron ions are bridged by histidine residues, while in deoxy-hemocyanin, the copper ions are bridged by histidine residues.

Statement D: they prefer to bind only one O2 per active site
- This statement is incorrect. Deoxy-hemerythrin can bind two oxygen molecules per active site, while deoxy-hemocyanin can bind only one oxygen molecule per active site. Therefore, this statement is only true for deoxy-hemocyanin, not for deoxy-hemerythrin.

Correct Statements:

Based on the analysis above, the correct statements are:

- A. they are involved in O2 transport in biological systems
- B. they contain two metal ions in their active site (only true for deoxy-hemerythrin)
- D. they prefer to bind only one O2 per active site (only true for deoxy-hemocyanin)

Therefore, the correct answer is option 'A' (A, B, and D).
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Consider the following statements for deoxy-hemerythrin and deoxy-hemocyanin:A. they are involved in O2 transport in biological systemsB. they contain two metal ions in their active siteC. active site metal centres are bridged by amino acid residuesD. they prefer to bind only one O2 per active siteThe correct statements area)A, B and Db)A, C and Dc)B, C and Dd)A and CCorrect answer is option 'A'. Can you explain this answer?
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