Apolipoprotein B on the surface of an LDL particle binds to the LDL receptor found in clathrin-coated pits during receptor-mediated endocytosis. Endocytosis is used to internalize the receptor-LDL complex, which is then transported to lysosomes before being recycled. With familial hypercholesterolemia, a patient presents. This may be because of:a)mutation in the LDL molecule.b)defect in LDL-receptor recycling.c)mutation in the LDL-receptor.d)defect in cholesterol binding with its receptor.Correct answer is option 'C'. Can you explain this answer?

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Software Development Exam > Software Development Questions > Apolipoprotein B on the surface of an LDL par...

a)
mutation in the LDL molecule.
b)
defect in LDL-receptor recycling.
c)
mutation in the LDL-receptor.
d)
defect in cholesterol binding with its receptor.

Correct answer is option 'C'. Can you explain this answer?

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Apolipoprotein B on the surface of an LDL particle binds to the LDL re...

Concept:

High blood cholesterol levels are a hallmark of the genetic illness known as familial hypercholesterolemia.
A waxy, fatty molecule resembling fat, cholesterol is created by the body and taken through foods derived from animals (particularly egg yolks, meat, poultry, fish, and dairy products).
This substance is necessary for the body to manufacture specific hormones, cell membranes, and molecules that help with fat digestion.
As a result of the body's inability to eliminate additional cholesterol, it builds up in the blood in those with familial hypercholesterolemia.
Heart disease risk rises when a person has too much cholesterol.

Explanation:

Fig 1:
Familial hypercholesterolemia

Familial hypercholesterolemia is brought on by mutations in the APOB, LDLR, LDLRAP1, or PCSK9 genes. The most frequent cause of this illness is changes in the LDLR gene.
Low-density lipoprotein receptor is a protein that is made according to instructions from the LDLR gene.
Low-density lipoproteins (LDLs), the main cholesterol-carrying components of the blood, are what this type of receptor binds to.
These receptors are essential for controlling cholesterol levels because they eliminate LDLs from the bloodstream.
The quantity of low-density lipoprotein receptors produced by cells is decreased by several LDLR gene mutations.
The removal of low-density lipoproteins from the bloodstream is impaired by other mutations that affect the receptors.
People who have LDLR gene mutations consequently have extremely high blood cholesterol levels.

hence the correct answer is option 3

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Apolipoprotein B on the surface of an LDL particle binds to the LDL receptor found in clathrin-coated pits during receptor-mediated endocytosis. Endocytosis is used to internalize the receptor-LDL complex, which is then transported to lysosomes before being recycled. With familial hypercholesterolemia, a patient presents. This may be because of:a)mutation in the LDL molecule.b)defect in LDL-receptor recycling.c)mutation in the LDL-receptor.d)defect in cholesterol binding with its receptor.Correct answer is option 'C'. Can you explain this answer?

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Apolipoprotein B on the surface of an LDL particle binds to the LDL receptor found in clathrin-coated pits during receptor-mediated endocytosis. Endocytosis is used to internalize the receptor-LDL complex, which is then transported to lysosomes before being recycled. With familial hypercholesterolemia, a patient presents. This may be because of:a)mutation in the LDL molecule.b)defect in LDL-receptor recycling.c)mutation in the LDL-receptor.d)defect in cholesterol binding with its receptor.Correct answer is option 'C'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about Apolipoprotein B on the surface of an LDL particle binds to the LDL receptor found in clathrin-coated pits during receptor-mediated endocytosis. Endocytosis is used to internalize the receptor-LDL complex, which is then transported to lysosomes before being recycled. With familial hypercholesterolemia, a patient presents. This may be because of:a)mutation in the LDL molecule.b)defect in LDL-receptor recycling.c)mutation in the LDL-receptor.d)defect in cholesterol binding with its receptor.Correct answer is option 'C'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Apolipoprotein B on the surface of an LDL particle binds to the LDL receptor found in clathrin-coated pits during receptor-mediated endocytosis. Endocytosis is used to internalize the receptor-LDL complex, which is then transported to lysosomes before being recycled. With familial hypercholesterolemia, a patient presents. This may be because of:a)mutation in the LDL molecule.b)defect in LDL-receptor recycling.c)mutation in the LDL-receptor.d)defect in cholesterol binding with its receptor.Correct answer is option 'C'. Can you explain this answer?.

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