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Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.
- a)interleukin-3.
- b)granulocyte-macrophage colony stimulating factor.
- c)macrophage-colony stimulating factor.
- d)granulocyte-colony stimulating factor.
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating ...
Concept:
- Different types of stem cells are targeted by a number of cytokines that alter proliferationdifferentiation, or other properties of stem cells.
- Stem cells are known to express various cytokinegenes. As IL-12, IL-14, G-CSF, and GM-CSF expression is lost after the differentiation of MSCs,these factors might have major contribution to pluripotency.
- Several other cytokines that are produced by immune cells, frequently target stem cells.
- Modulation of stem cell functions bycytokines can be a cause of various diseases including cancer.
- Stem cells can showimmunosuppressive properties by a number of mechanisms.
- Cytokines are small glycoprotein messengers that facilitate efficient communication amongimmune cells.
- Cytokines not only control innate and adaptive immune responses, but also affect non-immuneorgans and tissues.
Explanation:
- Stem cells are not only known to express various cytokine receptors, but also respond to variouscytokines by activation of conventional cytokine signaling pathways.
- Effects of various 'colony stimulating factors' (CSFs) to stimulategrowth of distinct colonies in bone marrow is the hallmark of stem cell biology.
- In this regardGranulocyte colony-stimulating factor (G-CSF), Granulocyte macrophage colony-stimulatingfactor (GM-CSF), Macrophage colony-stimulating factor (M-CSF), Interleukin-3 (IL-3),Interleukin-6 (IL-6), erythropoietin (EPO), thrombopoietin (TPO), Stem cell factor (SCF), flt3/flk-2 Ligand (FL), and leukemia inhibitory factor (LIF) are most important
- IL-3 is crucial for proliferation and survival of Hematopoietic Stem Cells (HSCs)and in absence of IL-3, HSCs may remain quiescent.
- Because of its crucial role, IL-3 is routinely used during proliferation and differentiation of HSCs.been very useful for
- The responsive bone marrow cells obtained by depleting the marrow of cells bearing defined lineage markers (neutrophils, macrophages, and lymphoid cells) and enriched for primitive myeloid progenitor cells with high proliferative potential, where studied for expressing sca-1.
- The sca-1-positive megakaryocyte progenitors formed colonies in the presence of interleukin 3 (IL-3) alone.
hence the correct answer is option 1
Most Upvoted Answer
Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating ...
Interleukin-3 stimulation resulted in the most numerous and diverse colonies
Interleukin-3 is a cytokine that plays a crucial role in the growth and differentiation of hematopoietic cells. When Sca-1+ cells were cultured in the presence of interleukin-3, it led to the production of the most numerous and diverse colonies compared to other stimulating factors.
- Interleukin-3: This cytokine promotes the proliferation and differentiation of hematopoietic stem cells, leading to the formation of various types of blood cells. It supports the growth of multiple cell lineages, resulting in a diverse range of colonies.
- Granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were also used to cultivate the Sca-1+ cells. However, the culture stimulated with interleukin-3 showed the highest number and variety of colonies, indicating its superior ability to support the growth and differentiation of these cells.
Therefore, based on the results of the experiment, interleukin-3 was the most effective stimulant for producing numerous and diverse colonies from Sca-1+ cells in mouse bone marrow.
Interleukin-3 is a cytokine that plays a crucial role in the growth and differentiation of hematopoietic cells. When Sca-1+ cells were cultured in the presence of interleukin-3, it led to the production of the most numerous and diverse colonies compared to other stimulating factors.
- Interleukin-3: This cytokine promotes the proliferation and differentiation of hematopoietic stem cells, leading to the formation of various types of blood cells. It supports the growth of multiple cell lineages, resulting in a diverse range of colonies.
- Granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were also used to cultivate the Sca-1+ cells. However, the culture stimulated with interleukin-3 showed the highest number and variety of colonies, indicating its superior ability to support the growth and differentiation of these cells.
Therefore, based on the results of the experiment, interleukin-3 was the most effective stimulant for producing numerous and diverse colonies from Sca-1+ cells in mouse bone marrow.
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Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.a)interleukin-3.b)granulocyte-macrophage colony stimulating factor.c)macrophage-colony stimulating factor.d)granulocyte-colony stimulating factor.Correct answer is option 'A'. Can you explain this answer?
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Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.a)interleukin-3.b)granulocyte-macrophage colony stimulating factor.c)macrophage-colony stimulating factor.d)granulocyte-colony stimulating factor.Correct answer is option 'A'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.a)interleukin-3.b)granulocyte-macrophage colony stimulating factor.c)macrophage-colony stimulating factor.d)granulocyte-colony stimulating factor.Correct answer is option 'A'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.a)interleukin-3.b)granulocyte-macrophage colony stimulating factor.c)macrophage-colony stimulating factor.d)granulocyte-colony stimulating factor.Correct answer is option 'A'. Can you explain this answer?.
Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.a)interleukin-3.b)granulocyte-macrophage colony stimulating factor.c)macrophage-colony stimulating factor.d)granulocyte-colony stimulating factor.Correct answer is option 'A'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.a)interleukin-3.b)granulocyte-macrophage colony stimulating factor.c)macrophage-colony stimulating factor.d)granulocyte-colony stimulating factor.Correct answer is option 'A'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Stem cell antigen -1+ (Sca - 1+) cells were produced by fractionating mouse bone marrow cells. Interleukin-3, granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and granulocyte colony stimulating factor were used to cultivate these cells. In the culture that was stimulated with, the most numerous and diverse colonies were produced.a)interleukin-3.b)granulocyte-macrophage colony stimulating factor.c)macrophage-colony stimulating factor.d)granulocyte-colony stimulating factor.Correct answer is option 'A'. Can you explain this answer?.
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