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Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria were
- a)BALB/b mice receiving the bacteria.
- b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.
- c)mice deficient in Toll-like receptor.
- d)DALD/c mice receiving thebacteria.
Correct answer is option 'B'. Can you explain this answer?
Verified Answer
Toll-like receptor 4 is associated with responsiveness to LPS, an endo...
Concept:
- Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs).
- They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections.
- TLR4 has been long recognized as the sensing receptor for gram-negative lipopolysaccharide (LPS).
- In addition, it also binds endogenous molecules produced as a result of tissue injury.
- Hence, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response.
- TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response.
Explanation:
- Inflammation within the central nervous system (CNS) has devastating consequences.
- Toll-like receptors (TLRs) have important roles in detecting pathogens and initiating inflammatory responses that, subsequently, prime specific adaptive immune responses during infection.
- It is therefore important that TLR signaling pathways are tightly regulated.
- One of the most effective suppressor of TLR-induced inflammatory cytokine production is IL-10, which displays powerful inhibitory actions on innate immune cells not only by direct inhibition of cytokine transcription but also by destabilizing their coding RNA (6) and blocking their translation.
Option 1:
BALB/b mice receiving the bacteria.
- Consider the explanation above thus the mice dies, so this option is not true
Option 2:
BALB/b mice receiving the bacteria and the anti-IL-10 antibody.
- Consider the explanation above, effective suppressor of TLR-induced inflammatorycytokine IL-10, displays powerful inhibitory actions on innate immune cells.
- So bacteria and anti-IL-10 antibody will neutralize effect of IL-10 and mice will have appropriate immune response to kill bacteria.
- thus this option is true
Option 3:
mice deficient in Toll-like receptor.
- Consider the explanation above thus the mice dies
Option 4:
DALD/c mice receiving the
bacteria
.
- Consider the explanation above thus the mice dies
hence the correct answer is option 2
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Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer?
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Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer?.
Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer?.
Solutions for Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria werea)BALB/b mice receiving the bacteria.b)BALB/b mice receiving the bacteria and the anti-IL-10 antibody.c)mice deficient in Toll-like receptor.d)DALD/c mice receiving thebacteria.Correct answer is option 'B'. Can you explain this answer? in English & in Hindi are available as part of our courses for Software Development.
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