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Video: Krebs Cycle (Aerobic Respiration) Video Lecture | Biology for JAMB

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1. What is the Krebs Cycle?

Ans. The Krebs Cycle, also known as the citric acid cycle, is a series of chemical reactions that occur in the mitochondria of cells during aerobic respiration. It is an essential part of the energy production process and plays a crucial role in the breakdown of carbohydrates, fats, and proteins to generate ATP (adenosine triphosphate).

2. How does the Krebs Cycle work?

Ans. The Krebs Cycle begins with the combination of a two-carbon molecule, acetyl-CoA, with a four-carbon molecule, oxaloacetate, to form a six-carbon molecule called citrate. This citrate molecule undergoes a series of reactions that release carbon dioxide and generate energy-rich molecules such as NADH, FADH2, and ATP. The cycle then regenerates oxaloacetate to continue the process.

3. What is the significance of the Krebs Cycle in aerobic respiration?

Ans. The Krebs Cycle is a vital part of aerobic respiration as it is the final common pathway for the oxidation of carbohydrates, fats, and proteins. It produces energy-rich molecules such as NADH and FADH2, which are essential for the electron transport chain to generate ATP. Additionally, the cycle also produces intermediates that are used in other metabolic pathways.

4. What are the main inputs and outputs of the Krebs Cycle?

Ans. The main inputs of the Krebs Cycle are acetyl-CoA, which is derived from the breakdown of carbohydrates, fats, and proteins, and oxaloacetate. The main outputs of the cycle are carbon dioxide, NADH, FADH2, and ATP. These outputs are then used in the electron transport chain to produce additional ATP through oxidative phosphorylation.

5. How is the Krebs Cycle regulated?

Ans. The Krebs Cycle is regulated by several factors, including the availability of substrates such as acetyl-CoA and oxaloacetate, as well as the presence of key enzymes that catalyze the reactions. The cycle is also regulated by feedback inhibition, where the accumulation of ATP and NADH can inhibit key enzymes and slow down the cycle to maintain cellular energy balance.

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