UPSC Exam > UPSC Notes > Medical Science Optional Notes for UPSC > CML: Pathology
CML: Pathology | Medical Science Optional Notes for UPSC PDF Download
| Table of contents |
|
| Pathogenesis of CML |
|
| CML Clinicopathology |
|
| Cirrhosis of Liver - Etiology |
|
| Cirrhosis of Liver - Pathogenesis |
|
| Cirrhosis of Liver - Histopathology |
|
Pathogenesis of CML
CML Clinicopathology
- Asymptomatic
- CML burden
- Thrombotic/Hyperviscocity related features
- Platelet dysfunction
Question for CML: PathologyTry yourself: Which feature is associated with thrombotic/hyperviscosity-related manifestations in CML?View Solution
Cirrhosis of Liver - Etiology
Cirrhosis is described as a widespread condition marked by fibrosis and the transformation of the typical liver structure into structurally irregular nodules. The extent of cirrhosis varies depending on the size of these nodules-
Cirrhosis of Liver - Pathogenesis
Cirrhosis of Liver - Histopathology
Delicate bands or broad scars, known as fibrous septa, surround multiple adjacent lobules. Parenchymal nodules are encompassed by these fibrous bands. The regeneration process involves preexisting long-lived hepatocytes and newly formed hepatocytes derived from stem cells, particularly the canals of Hering.
Question for CML: PathologyTry yourself: What is the process involved in the regeneration of hepatocytes in cirrhosis of the liver?View Solution
The document CML: Pathology | Medical Science Optional Notes for UPSC is a part of the UPSC Course Medical Science Optional Notes for UPSC.
All you need of UPSC at this link: UPSC
|
7 videos|219 docs
|
FAQs on CML: Pathology - Medical Science Optional Notes for UPSC
| 1. What is the pathogenesis of chronic myeloid leukemia (CML)? |  |
Ans. CML is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (Ph chromosome), which results from a reciprocal translocation between chromosomes 9 and 22. This translocation leads to the formation of the BCR-ABL fusion gene, which produces a constitutively active tyrosine kinase. The BCR-ABL fusion protein drives the uncontrolled proliferation and survival of myeloid cells, leading to the development of CML.
| 2. What are the clinicopathological features of chronic myeloid leukemia (CML)? | |
Ans. CML typically presents with nonspecific symptoms such as fatigue, weight loss, and night sweats. Physical examination may reveal splenomegaly. Laboratory findings often show leukocytosis with a left shift, an increased number of basophils, and the presence of the Philadelphia chromosome or BCR-ABL fusion gene. Bone marrow examination demonstrates hypercellularity with an increased number of myeloid cells at various stages of maturation.
| 3. What is the etiology of cirrhosis of the liver? | |
Ans. Cirrhosis of the liver can have various etiologies, including chronic hepatitis B or C infection, alcohol abuse, non-alcoholic fatty liver disease (NAFLD), autoimmune hepatitis, and genetic disorders such as hemochromatosis or Wilson disease. Each etiology leads to chronic liver injury and inflammation, triggering a cascade of events that ultimately result in liver fibrosis and cirrhosis.
| 4. What is the pathogenesis of cirrhosis of the liver? | |
Ans. The pathogenesis of cirrhosis involves chronic liver injury, inflammation, and subsequent fibrosis. The initial insult, such as viral hepatitis or alcohol abuse, leads to hepatocyte cell death and inflammation. In response, the liver attempts to repair itself by activating hepatic stellate cells, which produce excessive amounts of extracellular matrix proteins (e.g., collagen). This excessive deposition of collagen leads to the formation of fibrous tissue, disrupting the normal liver architecture and impairing liver function.
| 5. What are the histopathological features of cirrhosis of the liver? | |
Ans. Histopathological evaluation of cirrhosis reveals characteristic features such as nodular regeneration and fibrosis. The liver tissue shows regenerative nodules surrounded by fibrous septa. Hepatocytes may demonstrate ballooning degeneration, Mallory bodies (eosinophilic cytoplasmic inclusions), and steatosis (accumulation of fat droplets). In advanced stages, there may be loss of normal liver architecture, with fibrous bands replacing the normal parenchyma.
Related Exams
About this Document
|
Dec 22, 2024 Last updated |
Document Description: CML: Pathology for UPSC 2024 is part of Medical Science Optional Notes for UPSC preparation.
The notes and questions for CML: Pathology have been prepared according to the UPSC exam syllabus. Information about CML: Pathology covers topics
like Pathogenesis of CML, CML Clinicopathology, Cirrhosis of Liver - Etiology, Cirrhosis of Liver - Pathogenesis, Cirrhosis of Liver - Histopathology and CML: Pathology Example, for UPSC 2024 Exam. Find important definitions, questions, notes, meanings, examples, exercises and tests below for CML: Pathology.
Introduction of CML: Pathology in English is available as part of our Medical Science Optional Notes for UPSC
for UPSC & CML: Pathology in Hindi for Medical Science Optional Notes for UPSC course.
Download more important topics related with notes, lectures and mock test series for UPSC
Exam by signing up for free. UPSC: CML: Pathology | Medical Science Optional Notes for UPSC
Description
Full syllabus notes, lecture & questions for CML: Pathology | Medical Science Optional Notes for UPSC - UPSC | Plus excerises question with solution to help you revise complete syllabus for Medical Science Optional Notes for UPSC | Best notes, free PDF download
Information about CML: Pathology
In this doc you can find the meaning of CML: Pathology defined & explained in the simplest way possible. Besides explaining types of
CML: Pathology theory, EduRev gives you an ample number of questions to practice CML: Pathology tests, examples and also practice UPSC
tests
|
Explore Courses for UPSC exam
|
|
Signup for Free!
Signup to see your scores go up within 7 days! Learn & Practice with 1000+ FREE Notes, Videos & Tests.
Related Searches
Free
,mock tests for examination
,CML: Pathology | Medical Science Optional Notes for UPSC
,study material
,Previous Year Questions with Solutions
,MCQs
,video lectures
,Important questions
,Sample Paper
,Semester Notes
,practice quizzes
,CML: Pathology | Medical Science Optional Notes for UPSC
,Viva Questions
,Extra Questions
,Summary
,past year papers
,shortcuts and tricks
,ppt
,CML: Pathology | Medical Science Optional Notes for UPSC
,Objective type Questions
,Exam
;
Additional Information about CML: Pathology for UPSC Preparation
CML: Pathology Free PDF Download
The CML: Pathology is an invaluable resource that delves deep into the core of the UPSC exam.
These study notes are curated by experts and cover all the essential topics and concepts, making your preparation more efficient and effective.
With the help of these notes, you can grasp complex subjects quickly, revise important points easily,
and reinforce your understanding of key concepts. The study notes are presented in a concise and easy-to-understand manner,
allowing you to optimize your learning process. Whether you're looking for best-recommended books, sample papers, study material,
or toppers' notes, this PDF has got you covered. Download the CML: Pathology now and kickstart your journey towards success in the UPSC exam.
Importance of CML: Pathology
The importance of CML: Pathology cannot be overstated, especially for UPSC aspirants.
This document holds the key to success in the UPSC exam.
It offers a detailed understanding of the concept, providing invaluable insights into the topic.
By knowing the concepts well in advance, students can plan their preparation effectively.
Utilize this indispensable guide for a well-rounded preparation and achieve your desired results.
CML: Pathology Notes
CML: Pathology Notes offer in-depth insights into the specific topic to help you master it with ease.
This comprehensive document covers all aspects related to CML: Pathology.
It includes detailed information about the exam syllabus, recommended books, and study materials for a well-rounded preparation.
Practice papers and question papers enable you to assess your progress effectively.
Additionally, the paper analysis provides valuable tips for tackling the exam strategically.
Access to Toppers' notes gives you an edge in understanding complex concepts.
Whether you're a beginner or aiming for advanced proficiency, CML: Pathology Notes on EduRev are your ultimate resource for success.
CML: Pathology UPSC Questions
The "CML: Pathology UPSC Questions" guide is a valuable resource for all aspiring students preparing for the
UPSC exam. It focuses on providing a wide range of practice questions to help students gauge
their understanding of the exam topics. These questions cover the entire syllabus, ensuring comprehensive preparation.
The guide includes previous years' question papers for students to familiarize themselves with the exam's format and difficulty level.
Additionally, it offers subject-specific question banks, allowing students to focus on weak areas and improve their performance.
Study CML: Pathology on the App
Students of UPSC can study CML: Pathology alongwith tests & analysis from the EduRev app,
which will help them while preparing for their exam. Apart from the CML: Pathology,
students can also utilize the EduRev App for other study materials such as previous year question papers, syllabus, important questions, etc.
The EduRev App will make your learning easier as you can access it from anywhere you want.
The content of CML: Pathology is prepared as per the latest UPSC syllabus.
|
© EduRev
|
Education Revolution
|
|
Signup to see your scores
go up within 7 days!
Access 1000+ FREE Docs, Videos and Tests
Takes less than 10 seconds to signup