Spermatogenesis Video Lecture - NEET

>>Dr. Ketchum: In this video lecture we are
going to be studying sperm and their development.
Okay, so just starting out with the sperm.
And remember that sperm are the male gamete,
and also be sure that you understand that
sperm are also called spermatozoa. That’s
the same thing. So if you hear the term spermatozoa,
we are referring to sperm.
Okay, so let’s look at the morphology and
what some of the important structures are
associated with the sperm. So you have three
different regions: there’s the head, the
midpiece, and the tail. So the head contains
a couple of important things, and number one
those are the chromosomes. And so what I would
like to ask you is how many autosomes are
there in the head, and how many sex chromosomes?
So if you want to pause the video for a moment
and think about that, then I’ll give you
the answer in just a minute. Okay, so remember
sperm are haploid. And because they’re haploid
that means they’re one n, so that means we’re
going to have 22 autosomes and one sex chromosome.
Okay, also associated with the head is the
area called the acrosome. The acrosome contains
the enzymes that are necessary for fertilization,
and we’re going to come back to the acrosome
and how sperm fertilized the egg later.
Then there’s the midpiece, the next region of
the sperm. And the midpiece contains the mitochondria.
Why are the mitochondria important for sperm?
So if you remember, the mitochondria are the
powerhouse for the cell. So that’s going
to produce ATP. Sperm are motile, and they
need the ATP in order to generate that energy
to move. The last component of the sperm
or the last segment is the tail. The tail
is called the flagellum, and so this is what
the sperm use in order to propel themselves.
So when we talk about motility of the sperm,
essentially, you can think about the flagellum
whipping. And its whip-like motion is what
propels the sperm, or causes the sperm to
move.
So how are those sperm produced? We’re going
to look at spermatogenesis. So this is the
process of sperm production; how the sperm
are actually produced. So keep in mind that
sperm production is associated with the Sertoli
cells, and remember that the Sertoli cells
are associated with the seminiferous tubules.
And so where we’re going to begin is at
the basement membrane, okay. And then you
have a Sertoli cell here on the left; you
have a Sertoli cell here on the right, and
we’re going to be talking about spermatogenesis
that’s occurring between the Sertoli cells.
So we’re going to start with a germ cell.
So the germ cells are the spermatogonia. Germ
cells are diploid—two n. Now remember that
you have two different compartments when it
comes to these Sertoli cells. You have what’s
called the basal compartment. So if you recall
that’s from the tight junction toward the
basement membrane, and the other compartment
is called the luminal compartment. So that
extends from the tight junction to the lumen.
We’re going to start at the basal compartment
with the spermatogonia and as the sperm migrates
toward the lumen, they’re undergoing development.
So beginning with the spermatogonia, males
are born with a finite number of spermatogonia.
And so the thing here though is that these
spermatogonia can undergo mitosis. And so
they continually, repeatedly divide; they
are dividing indefinitely after puberty. In
males, they keep producing spermatogonia throughout
their life. After they undergo mitosis, then
the spermatogonia are going to develop into
primary spermatocytes, and they do that by
undergoing mitosis. So those primary spermatocytes
then they are also diploid, because whenever
a cell undergoes mitosis the next—the cells
that’re derived from that are identical.
So these have to be diploid cells. Primary
spermatocytes then undergo meiosis one. So
when they undergo meiosis one, they’re going
to produce secondary spermatocytes. Secondary
spermatocytes are haploid, so they are one n.
Secondary spermatocytes then undergo meiosis
two to become spermatids, and then spermatids
undergo a maturation and development stage.
So they have to mature and develop to become
spermatozoa, a.k.a. sperm. So this is your
gamete, the male gamete. Okay, this process
spermatogenesis began with the spermatogonia,
mitosis took place, you produce primary spermatocytes,
then meiosis one occurred to produce secondary
spermatocytes, then meiosis two occurred to
produce spermatids. Then the spermatids matured
and developed into gametes, male gametes—spermatozoa. And all of this process was occurring as,
as the cells were migrating from the basal compartment
toward the luminal compartment. And once this
process is over, the sperm are actually in
the lumen of the seminiferous tubule.
And I put a little note for here that approximately
50 to 500 million sperm are actually ejaculated—
or that’s per ejaculation.