UPSC Exam > UPSC Notes > Medical Science Optional Notes for UPSC > Tuberculosis
Tuberculosis | Medical Science Optional Notes for UPSC PDF Download
| Table of contents |
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| Pathogenesis of Tuberculosis |
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| Membranous Nephropathy |
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| Nephrotic Syndrom |
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| CNS Tuberculosis |
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| Impaired Glucose Tolerance |
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Pathogenesis of Tuberculosis
A. Primary Pulmonary Tuberculosis (0-3 weeks)
B. Primary Pulmonary Tuberculosis (>3 weeks)
Membranous Nephropathy
Cause:
Pathogenesis:
Morphology:
Question for TuberculosisTry yourself: What is the cause of membranous nephropathy?View Solution
Nephrotic Syndrom
CNS Tuberculosis
Classification
Intracranial
- Tuberculous meningitis (TBM)
- Tuberculous encephalopathy
- Tuberculous vasculopathy
- CNS tuberculoma (Single or multiple)
- Tuberculous Brain Absce
Spinal
- Pott's spine and Pott's paraplegia
- Non-osseous spinal tuberculoma
- Spinal meningitis
Subarachnoid Space:
- Presence of exudate
- Involvement of arteries
Leptomeningeal Involvement:
- Microscopic alterations
Impaired Glucose Tolerance
Diagnostic Criteria for Impaired Glucose Tolerance (IGT)/Prediabetes/Impaired Fasting Glucose (IFG):
- IFG is defined as Fasting Plasma Glucose levels between 5.6-6.9 mmol/L (110-125 mg/dL).
- Impaired Glucose Tolerance (IGT) is characterized by plasma glucose levels between 7.8 and 11 mmol/L (140 and 199 mg/dL) following an oral glucose challenge.
- Prediabetes is identified by an A1C level ranging from 5.7-6.4%, as per the American Diabetes Association (ADA), or referred to as "increased risk of diabetes" or "intermediate hyperglycemia" by the World Health Organization (WHO).
Type 1 DM - Pathogenesis
Environment
Viruses:
- Coxsackie
- Rubella
- Enteroviruses
Proteins in Bovine Milk:
- Nitrosourea Compounds
Question for TuberculosisTry yourself: What is the diagnostic criteria for Impaired Glucose Tolerance (IGT)?View Solution
Islet cell autoantibodies
- Insulin
- GAD
- ZnT-8
- ICA-512/IA-2
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FAQs on Tuberculosis - Medical Science Optional Notes for UPSC
| 1. What is the pathogenesis of tuberculosis? |  |
Ans. Tuberculosis is caused by the bacteria Mycobacterium tuberculosis. When a person inhales the bacteria, it enters the lungs and infects the alveolar macrophages. These macrophages engulf the bacteria but are unable to kill them. Instead, the bacteria multiply within the macrophages and spread to other parts of the lungs.
The immune system responds by activating T cells, which form a granuloma around the infected macrophages, containing the infection. However, in some cases, the granuloma is unable to control the infection, leading to the formation of cavities in the lungs. The bacteria can then spread through the bloodstream or lymphatic system to other organs, causing extrapulmonary tuberculosis.
| 2. What is membranous nephropathy? | |
Ans. Membranous nephropathy is a kidney disease characterized by thickening and damage to the glomerular basement membrane, which is responsible for filtering waste and excess fluid from the blood. This thickening occurs due to the deposition of immune complexes, primarily antibodies, in the membrane.
The exact cause of membranous nephropathy is often unknown, but it can be associated with various underlying conditions, such as infections, autoimmune disorders, malignancies, and certain drugs. The condition can lead to nephrotic syndrome, a group of symptoms including proteinuria (excessive protein in the urine), edema (swelling), hypoalbuminemia (low blood albumin levels), and hyperlipidemia (high blood lipid levels).
| 3. What is nephrotic syndrome? | |
Ans. Nephrotic syndrome is a kidney disorder characterized by a group of symptoms, including proteinuria (excessive protein in the urine), edema (swelling), hypoalbuminemia (low blood albumin levels), and hyperlipidemia (high blood lipid levels).
It can be caused by various underlying conditions that affect the glomeruli, the tiny blood vessels in the kidneys responsible for filtering waste and excess fluid from the blood. These conditions include membranous nephropathy, minimal change disease, focal segmental glomerulosclerosis, and membranoproliferative glomerulonephritis.
Treatment for nephrotic syndrome involves addressing the underlying cause, managing symptoms, and preventing complications such as infections and blood clots. Medications like corticosteroids and immunosuppressants may be prescribed to reduce proteinuria and control the immune response.
| 4. What is CNS tuberculosis? | |
Ans. CNS tuberculosis refers to tuberculosis infection that affects the central nervous system, which includes the brain and spinal cord. It occurs when the bacteria Mycobacterium tuberculosis spread from another site in the body, usually the lungs, to the CNS.
Symptoms of CNS tuberculosis can vary and may include headache, neck stiffness, fever, altered mental status, seizures, and focal neurological deficits. The infection can lead to meningitis, tuberculoma (a mass or lesion in the brain), or spinal tuberculosis.
Treatment for CNS tuberculosis typically involves a combination of multiple anti-tuberculosis drugs for an extended period. Prompt diagnosis and treatment are crucial to prevent complications and reduce the risk of long-term neurological damage.
| 5. What is impaired glucose tolerance? | |
Ans. Impaired glucose tolerance (IGT) refers to a condition in which blood sugar levels are higher than normal but not high enough to be diagnosed as diabetes. It is considered a pre-diabetic state and indicates an increased risk of developing type 2 diabetes.
IGT occurs when the body's cells become less responsive to insulin, a hormone that helps regulate blood sugar levels. As a result, glucose remains in the bloodstream rather than being taken up by cells for energy.
Risk factors for impaired glucose tolerance include obesity, sedentary lifestyle, family history of diabetes, and certain medical conditions like polycystic ovary syndrome. Lifestyle modifications, such as regular exercise, healthy eating, and weight loss, can help manage IGT and reduce the risk of progressing to diabetes.
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Nov 21, 2024 Last updated |
Document Description: Tuberculosis for UPSC 2024 is part of Medical Science Optional Notes for UPSC preparation.
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