Gene Therapy | Animal Husbandry & Veterinary Science Optional for UPSC PDF Download

Overview of Gene Therapy

Gene therapy can be seen as an extension of traditional transplantation methods. The primary challenge of organ rejection in transplants can potentially be addressed through gene therapy.

Approaches in Gene Therapy

• The process involves extracting the patient's cells, repairing them by introducing normal genes, and then reintroducing the modified cells. Alternatively, normal genes can be directly inserted into the relevant tissues using methods like harmless viruses or liposomes carrying the necessary genetic material.

Current Progress and Challenges

• Extensive research is ongoing in the field of gene therapy, leading to significant advancements. However, there are still substantial practical obstacles that need to be overcome.

Applicability and Limitations

• Gene therapy is primarily useful for disorders where the affected gene is expressed in tissues that are accessible for treatment. One major limitation is its limited practicality in domestic animals due to the rapid progress in molecular technologies for detecting genetic disorders.

Human Applications

• In cases like humans, where genetic control methods are not acceptable, gene therapy may have a more significant impact. However, it's worth noting that much of the initial research in human gene therapy relies on animal models of human diseases, which are of interest to veterinarians.