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All questions of Chemical Coordination and Regulation for NEET Exam

Oxytocin helps in [1999]
  • a)
    lactation
  • b)
    child birth
  • c)
    ovulation
  • d)
    implantation of the embryo
Correct answer is option 'B'. Can you explain this answer?

Anjali Iyer answered
"Oxytocin is a peptide produced in the brain that was first recognized for its role in the birth process, and also in nursing," said Larry Young, a behavioral neuroscientist at Emory University in Atlanta, Georgia. The hormone causes uterine contractions during labor and helps shrink the uterus after delivery.

The most important component of the oral contraceptive pill is [1998]
  • a)
    growth hormone
  • b)
    thyroxine
  • c)
    luteinizing hormone
  • d)
    progesterone
Correct answer is option 'D'. Can you explain this answer?

Shruti Chauhan answered
Use of contraceptive pills is a wide spread form of birth control. contraceptive pills contain estrogen and progesterone. The production of the pituitary hormones FSH & LH in the normal sexual cycle of a female is shut down by these hormones. In the absence of FSH, the ovarian follicles  do not ripe and ovulation does not occur in the absence of LH.

Norepinephrine : [NEET Kar. 2013]
(1) Is released by sympathetic fibres
(2) Is released by parasympathetic fibres
(3) Increases the heart rate
(4) Decreases blood pressure
Which of the above said statements are correct?
  • a)
    (1) and (4)
  • b)
    (1) and (3)
  • c)
    (2) and (3)
  • d)
    (2) and (4)
Correct answer is option 'B'. Can you explain this answer?

Norepinephrine is released by sympathetic fibres i.e, rapidly secreted in response to stress of any kind and during emergency situations. It increases the heart beat, the strength of heart contraction and the rate of respiration.

Which of the following is an accumulation and release centre of neurohormones ? [2006]
  • a)
    Intermediate lobe of the pituitary
  • b)
    Hypothalamus
  • c)
    Anterior pituitary lobe
  • d)
    Posterior pituitary lobe
Correct answer is option 'D'. Can you explain this answer?

Neurohormones are actually secreted by the neurosecretory cells of the hypothalamus. They are circulated to the posterior part of the pituitary gland through the blood & stored there and released when required.

Which hormone possesses anti-insulin effect?[1988]
  • a)
    Cortisol
  • b)
    Calcitonin
  • c)
    Oxytocin
  • d)
    Aldosterone
Correct answer is option 'A'. Can you explain this answer?

Cortisol is secreted by the middle region of adrenal cortex. It increases the blood glucose level (which is anti-insulin effect) by converting proteins & fats into glucose.

Acromegaly is caused by [2002]
  • a)
    excess of G.H.
  • b)
    excess of thyroxin
  • c)
    deficiency of thyroxin
  • d)
    excess of adrenalin
Correct answer is option 'A'. Can you explain this answer?

Shivani Rane answered
Deficiency of thyroxin causes cretinism in infants and myxoedema in adults. Excess of adrenalin does not cause any disorder. Acromegaly is caused by over secretion of STH or somatotrophic hormone (Growth hormone). 

Which one of the following pairs of organs includes only the endocrine glands? [2008]
  • a)
    Parathyroid and Adrenal
  • b)
    Pancreas and Parathyroid
  • c)
    Thymus and Testes
  • d)
    Adrenal and Ovary 
Correct answer is option 'A'. Can you explain this answer?

Vaibhav Basu answered
Parathyroid and adrenal are the endocrine glands. Adrenal glands are the pairs of endocrine glands situated immediately above the kidneys. Hence they are also known as suprarenal glands. Parathyroid glands are the two pairs of endocrine glands -situated behind or embedded within, the thyroid gland in higher  vertebrates.  They  produce parathyroid hormone, which controls the  amount of calcium in the blood.

The mammalian corpus luteum produces  [1995]
  • a)
    estrogen
  • b)
    progesterone
  • c)
    luteotropic hormone
  • d)
    luteinizing hormone
Correct answer is option 'B'. Can you explain this answer?

Anu Bajaj answered
 Mammalian corpus luteum produces progesterone. It is essential for the continuation of pregnancy and it also stimulates acini glands.

MSH of pars intermedia of middle pituitary is responsible for [1988]
  • a)
    darkening of skin in lower vertebrates
  • b)
    Light colouration of skin in lower vertebrates
  • c)
    Both A and B
  • d)
    Darkening of skin in human beings
Correct answer is option 'A'. Can you explain this answer?

Melanocyte-stimulating hormone (MSH) or Melanotropin is secreted by the intermediate lobe of adenohypophysis (pars intermedia) of pituitary gland in mammals (other than man) so named ‘intermedin’. In lower vertebrates, it targets chromatophores & does wider distribution of the melanin grannules in chromatophores, so that the skin colour darkens. In birds & human beings and other mammals its role is uncertain but in man it is probably responsible for bronzing of skin, moles etc.

Injury to adrenal cortex is not likely to affect the secretion of which one of the following? [2010]
  • a)
    Aldosterone
  • b)
    Both Androstenedione and Dehydroepiandrosterone
  • c)
    Adrenaline
  • d)
    Cortisol
Correct answer is option 'C'. Can you explain this answer?

Abhiram Nair answered
Adrenal gland has two parts-cortex and medulla. The medulla is stimulated by sympathetic nervous tissue to produce adrenaline and non-adrenaline while the cortex is stimulated by pituitary hormone to release cortisol, aldosterone and estrogens. Thus injury to adrenal cortex is not likely to affect the secretion of adrenaline

Sertoli cells are regulated by the pituitary hormone known as [2006]
  • a)
    GH
  • b)
    Prolactin
  • c)
    LH
  • d)
    FSH
Correct answer is option 'D'. Can you explain this answer?

Sertoli cells are the cells that line the seminiferous tubules in the testis. These cells protect the spermatids and convey nutrients to both the developing and mature spermatozoa. Sertoli cells are regulated by FSH (Follicle Stimulating Hormone)which is secreted by the anterior pituitary. FSH stimulates Sertoli cells to produce androgen-binding protein and inhibin and together with testosterone, promotes the proliferation of Sertoli cells. So, the correct answer is option 'D'.

Which one of the following  statement is correct? [2006]
  • a)
    Endrocrine glands regulate neural activity, and nervous system regulates endocrine glands
  • b)
    Neither hormones control neural activity nor the neurons control endocrine activity
  • c)
    Endocrine glands regulate neural activity, but not vice versa
  • d)
    Neurons regulate endocrine activity, but not vice versa
Correct answer is option 'A'. Can you explain this answer?

Endocrine glands regulate neural activity as endocrine glands secrete epinephrine & norepinephrine which have their effects on neuron activity. On the other hand neuron also controls the activity of endocrine glands by secreting neurohormones which regulate the activity of many endocrine glands.

Which of the following statements is correct in relation to the endocrine system? [NEET 2013]
  • a)
    Organs in the body like gastrointestinal tract, heart, kidney and liver do not produce any hormones.
  • b)
    Non-nutrient chemicals produced by the body in trace amount that act as intercellular messenger are known as hormones.
  • c)
    Releasing and inhibitory hormones are produced by the pituitary gland .
  • d)
    Adenohypophysis is under direct neural regulation of the hypothalamus.
Correct answer is option 'B'. Can you explain this answer?

Hormones are non-nutrient chemicals which act as intercellular messengers and are produced in trace amounts.
Gastrointestinal tracts secretes four major peptide hormones – gastrin, secretin, cholecystokinin (CCK) and gastric inhibitory peptide (GIP) while juxtaglomerular cells of kidney secretes erythropoietin, a peptide hormone. Releasing and inhibitory hormones are produced by hypothalamus. Neurohypophysis or posterior pituitary is under direct neural regulation of the hypothalamus.

Which hormone causes dilation of blood vessels, increased oxygen consumption and glucogenesis? [2006]
  • a)
    Insulin
  • b)
    Adrenaline
  • c)
    Glucagon
  • d)
    ACTH
Correct answer is option 'B'. Can you explain this answer?

Nayanika Reddy answered
 Adrenaline (called Frieght-Flight-Fight hormone) in responsible for the dilation of blood vessels, increased oxygen consumption by tissues & glucogenesis to prepare the body for emergency reactions under the threatening conditions.

When both ovaries are removed from rat then which hormone is decreased in blood? [2002]
  • a)
    Oxytocin
  • b)
    Prolactin
  • c)
    Estrogen
  • d)
    Gonadotropin releasing factor
Correct answer is option 'C'. Can you explain this answer?

Krish Khanna answered
Estrogen is released from the ovarian follicles. Oxytocin is secreted by posterior pituitary and prolactin is released by anterior pituitary. Gonadotropin releasing factor is produced by hypothalamus.

Calcitonin is a thyroid hormone which [1998]
  • a)
    lowers calcium level in blood
  • b)
    elevates calcium level in blood
  • c)
    has no effect on calcium
  • d)
    elevates potassium level in blood
Correct answer is option 'A'. Can you explain this answer?

Krish Khanna answered
Calcitonin  is a polypeptide hormone which lowers calcium and phosphate level of plasma by inhibiting  bone degradation and stimulating their uptake by bone parathyroid  harmone elevates calcium level in blood.

Mainly which type of hormones control the menstrual cycle in human beings? [2002]
  • a)
    FSH
  • b)
    LH
  • c)
    FSH, LH, estrogen
  • d)
    Progesteron
Correct answer is option 'C'. Can you explain this answer?

Estrogens are steroid hormones secreted by growing ovarian follicles. During menstrual cycle a negative feedback prevents the over secretion of estrogen. FSH stimulates maturation of Graafian follicles. LH stimulates ovulation and development of corpus luteum.

Hormones, thyroxine, adrenaline and the pigment melanin are formed from [1997]
  • a)
    tryptophan
  • b)
    glycine
  • c)
    tyrosine
  • d)
    proline
Correct answer is option 'C'. Can you explain this answer?

Snehal Shah answered
The amino acid glycine forms porphyrin ring in chlorophyll and haeme proteins like haemoglobin. Tryptophan gives rise to plant hormone indole- 3 - acetic acid.

Nicotine acts as a stimulant, because it mimics the effect of [1995]
  • a)
    thyroxine
  • b)
    acetylcholine
  • c)
    testosterone
  • d)
    dopamine
Correct answer is option 'B'. Can you explain this answer?

Rajeev Saxena answered
Nicotine initially stimulates and subsequently in high doses inhibits neural impulses at autonomic ganglia and the neuromuscular junction.

Parathormone deficiency produces muscle ramps or tetany as a result of [1999]
  • a)
    lowered blood Ca2+
  • b)
    enhanced blood Na+
  • c)
    enhanced blood glucose
  • d)
    enhanced blood Ca2+
Correct answer is option 'A'. Can you explain this answer?

Rajesh Datta answered
Parathormone released by the parathyroid gland  elevates the level of  Ca2+ in blood. The deficiency of this hormone lowers blood Ca2+. As a  result,  the excitability of muscles and nerves increases producing tetany -sustained contraction.

A candidate vaccine for male contraception is based on [1999]
  • a)
    follicle stimulating hormone
  • b)
    progesterone
  • c)
    testosterone
  • d)
    luteinizing hormone
Correct answer is option 'C'. Can you explain this answer?

Abhishek Desai answered
Progesterone is a steroid hormone secreted by corpus luteum and causes routine temporary changes in the endometrial lining of uterus. Follicle stimulating hormone secreted by anterior pituitary lobe stimulates spermatogenesis in testes of males. Luteinizing hormone  activates Leydig’s cells of testes to secrete  testosterones.

Select the correct statement.     [2020]
  • a)
    Insulin acts on pancreatic cells and adipocytes.
  • b)
    Insulin is associated with hyperglycemia.
  • c)
    Glucocorticoids stimulate gluconeogenesis.
  • d)
    Glucagon is associated with hypoglycemia.
Correct answer is option 'C'. Can you explain this answer?

Glucocorticoids stimulate gluconeogenesis
Glucocorticoids are a class of steroid hormones that are produced in the adrenal glands. One of the main functions of glucocorticoids, such as cortisol, is to regulate metabolism. One way they do this is by stimulating the process of gluconeogenesis, which is the production of glucose from non-carbohydrate sources like amino acids and glycerol.

Role of Gluconeogenesis
Gluconeogenesis is an important metabolic pathway that helps maintain blood glucose levels during fasting or prolonged exercise. By increasing gluconeogenesis, glucocorticoids ensure that there is a steady supply of glucose available for the body to use as energy.

Regulation of Gluconeogenesis
Glucocorticoids stimulate gluconeogenesis by upregulating the expression of key enzymes involved in the pathway, such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase. This leads to an increase in the production of glucose from precursors in the liver.

Impact on Blood Glucose Levels
Due to their role in stimulating gluconeogenesis, glucocorticoids can lead to an increase in blood glucose levels. This is why glucocorticoid medications, such as prednisone, are associated with side effects like hyperglycemia in some individuals.
In conclusion, glucocorticoids play a crucial role in the regulation of metabolism, particularly by stimulating gluconeogenesis to ensure a constant supply of glucose for the body's energy needs.

Insulin is [1990]
  • a)
    vitamin
  • b)
    lipid
  • c)
    hormone
  • d)
    enzyme
Correct answer is option 'C'. Can you explain this answer?

Shalini Saha answered
Insulin is a hormone secreted by the b-cells of pancreas and it controls the sugar level in blood

Which one of the following hormone stimulates the “let-down” (release) of milk from the mother’s breasts when the baby is sucking ? [1996]
  • a)
    Progesterone
  • b)
    Oxytocin
  • c)
    Prolactin
  • d)
    Relaxin
Correct answer is option 'B'. Can you explain this answer?

Prolactin is a proteinaceous hormone released by anterior lobe of pituitary. Prolactin supplements the action of gonadal hormones in stimulating the growth and activity of female mammary gland during  pregnancy and lactation. Oxytocin released by the posterior lobe of pituitary gland, is important for the mechanism of ejection of milk from the mammary glands due to sucking of breasts by infant. Progesterone, released by corpus luteum  brings about pregnancy changes such as uterine growth, implantation of embryo etc. Relaxin  is a proteinaceous hormone secreted by corpus luteum towards the end  of gestation period for loosening and softening of pelvic ligaments, relaxing of uterus for easing parturition.

Which part of ovary in mammals acts as an endocrine gland after ovulation ? [2007]
  • a)
    Stroma
  • b)
    Germinal epithelium
  • c)
    Vetelline membrane
  • d)
    Graafian follicle.
Correct answer is option 'D'. Can you explain this answer?

Anand Jain answered
Graafian follicle – the ovarian medulla contains many rounded or oval bodies, called ovarian, or grafian follicles, at various stages of development. Each follicle contains a large ovum surrounded by many layers of follicle cells.

A pregnant female deliver a baby who suffers from stunted growth, mental retardation/low intelligence quotient and abnormal skin. This is the result of : [NEET 2013]
  • a)
    Low secretion of growth hormone
  • b)
    Cancer of the thyroid gland
  • c)
    Over secretion of pars distalis
  • d)
    Deficiency of iodine in diet
Correct answer is option 'D'. Can you explain this answer?

Yashvi Malik answered
Explanation:

The correct answer is option D, i.e., deficiency of iodine in diet. Iodine is an essential micronutrient required for the synthesis of thyroid hormones. During pregnancy, the demand for iodine increases, and if the maternal diet lacks iodine, it can lead to several fetal abnormalities, including stunted growth, mental retardation/low intelligence quotient, and abnormal skin. This condition is known as cretinism or congenital hypothyroidism.

Iodine deficiency during pregnancy can lead to the following consequences:

1. Stunted growth: Iodine is required for the development of bones and muscles in the fetus. In the absence of iodine, the growth of the fetus is impaired, leading to stunted growth.

2. Mental retardation/low intelligence quotient: Iodine is crucial for the development of the nervous system, including the brain. Inadequate iodine intake during pregnancy can lead to irreversible damage to the developing brain, resulting in mental retardation and low intelligence quotient.

3. Abnormal skin: Iodine deficiency can lead to dry and scaly skin, which is a characteristic feature of cretinism.

Prevention:

Iodine deficiency during pregnancy can be prevented by ensuring an adequate intake of iodine through the diet or iodine supplements. Foods rich in iodine include iodized salt, seafood, dairy products, and eggs.

Conclusion:

In conclusion, iodine deficiency during pregnancy can have severe consequences on fetal growth and development, leading to stunted growth, mental retardation/low intelligence quotient, and abnormal skin. It is essential to ensure an adequate intake of iodine during pregnancy to prevent these complications.

Parkinson’s disease (characterized by tremors and progressive rigidity of limbs) is caused by degeneration of brain neurons that are involved in movement control and make use of neurotransmitter [2005]
  • a)
    acetylcholine
  • b)
    norepinephrine
  • c)
    dopamine
  • d)
    GABA
Correct answer is option 'C'. Can you explain this answer?

Ishaan Menon answered
Parkinson’s disease (Paralysis agitans) (i) It develops due to deficiency of neuro transmitter, dopamine. The dopamine is not produced due to gradual destruction of neurons in the substantia nigra. (ii) It produces muscle tremors so called shaking palsy. (iii) There is lack of control and coordination of movements resulting in expression less face and stooping posture which gradually produces physical disability.

Which one of the following does not act as a neurotransmitter ? [2006]
  • a)
    Epinephrine
  • b)
    Norepinephrine
  • c)
    Cortisone
  • d)
    Acetylcholine
Correct answer is option 'C'. Can you explain this answer?

Naveen Menon answered
Epinephrine or adrenaline, norepinephrine or noradrenaline and acetylchloline are the neurotransmitters. These are released by the nerve fibres to transmit the impulse to the next neurone. Cortisone is not the neurotransmitter.

Adrenaline directly affects on [2002]
  • a)
    S. A. node
  • b)
    b-cells of Langerhans
  • c)
    dorsal root of spinal cord
  • d)
    epithelial cells of stomach
Correct answer is option 'A'. Can you explain this answer?

Dhruba Sharma answered

Effect of Adrenaline on the S. A. Node

Adrenaline directly affects the S. A. (sinoatrial) node, which is often referred to as the heart's natural pacemaker. The S. A. node is a cluster of cells located in the right atrium of the heart that initiates the electrical impulses responsible for coordinating the heart's contractions.

Stimulation of the S. A. Node

When adrenaline binds to its receptors on the S. A. node cells, it leads to an increase in the heart rate. This occurs because adrenaline stimulates the S. A. node to generate electrical impulses at a faster rate, causing the heart to beat more rapidly. This response is part of the body's fight or flight response, preparing the body for action by increasing blood flow and oxygen delivery.

Effects on Heart Function

The stimulation of the S. A. node by adrenaline results in an increase in both heart rate and the force of heart contractions. This leads to an overall increase in cardiac output, allowing more blood to be pumped to the body's tissues and organs.

Regulation of Heart Rate

The effects of adrenaline on the S. A. node play a crucial role in regulating heart rate in response to stress or physical activity. By increasing heart rate and cardiac output, adrenaline helps to ensure that the body can meet the increased demand for oxygen and nutrients during times of exertion or danger.

In conclusion, adrenaline directly affects the S. A. node in the heart, leading to an increase in heart rate and cardiac output. This response is essential for the body's ability to respond to stress and physical activity.

How does steroid hormone influence the cellular activities?    [2019]
  • a)
    Using aquaporin channels ‘as second messenger'
  • b)
    Changing the permeability of the cell membrane
  • c)
    Binding to DNA and forming a gene- hormone complex
  • d)
    Activating cyclic AMP located on the cell membrane
Correct answer is option 'C'. Can you explain this answer?

Gaurav Kumar answered
Steroid hormones are lipid-soluble and easily pass through the cell membrane of a target cell into the cytoplasm where they bind to specific intracellular receptors (proteins) to form a hormone receptor complex that enters the nucleus. In the nucleus, hormone which interact with intracellular receptors mostly regulate gene expression or chromosome function by the interaction of hormone-receptor complex with the genome. Biochemical actions result in physiological and developmental effects.

A steroid hormone which regulates glucose metabolism is
  • a)
    corticosterone
  • b)
    11- deoxycorticosterone
  • c)
    cortisone
  • d)
    cortisol
Correct answer is option 'D'. Can you explain this answer?

Ishani Nambiar answered
Cortisole is the steroid hormone secreted by adrenal cortex and plays an important role in carbohydrate metabolism. It retards the glucose consumption & hence level of glucose in blood increases & blood pressure increases.

What is correct to say about the hormone action in humans [2012]
  • a)
    Glucagon is secreted by β -cells of islets of Langerhans and stimulates glycogenolysis
  • b)
    Secretion of thymosins is stimulated with ageing
  • c)
    In females FSH first binds with specific receptors on ovarian cell membrane
  • d)
    FSH stimulates the secretion of estrogen and progesterone
Correct answer is option 'C'. Can you explain this answer?

Glucagon is secreted by α cells of islets  of langerhans and stimulate glycogenolysis i.e. breakdown of glycogen into glucose Thymosin hormone secreted from thymus gland stimulates the development of certain kinds of white blood cells involved in producing immunity. It also hostens attainment of sexual maturity.

Match the source gland with respective hormone as well as the function correctly. [2011]
  • a)
    a
  • b)
    b
  • c)
    c
  • d)
    d
Correct answer is option 'B'. Can you explain this answer?

Krish Patel answered
Posterior pituitary releases vasopressin which stimulates reabsorption of water in the distal tubules in nephron.

Melanocyte stimulating hormone (MSH) is produced by [2000]
  • a)
    parathyroid
  • b)
    pars intermedia of pituitary
  • c)
    anterior pituitary
  • d)
    posterior pituitary
Correct answer is option 'B'. Can you explain this answer?

Ayush Sengupta answered
Parathyroid gland secretes parathormone which regulates Ca2+ level in blood. Anterior lobe of pituitary secretes the following hormones growth hormone, ACTH, TSH, FSH, LH. Posterior pituitary secretes vasopressin and oxytocin.
The intermediate lobe (pars intermedium) of the pitutary gland secretes MSH which causes dispersal of pigment granules in the pigment cells which give colour to the skin

Feeling the tremors of an earthquake a scared resident of seventh floor of a multistored building starts climbing down the stairs rapidly. Which hormone initiated this action ? [2007]
  • a)
    adrenaline
  • b)
    glucagon
  • c)
    gastrin
  • d)
    thyroxine
Correct answer is option 'A'. Can you explain this answer?

It is commonly called as ‘emergency hormone’ or 3F – hormone (For fear, fight & flight). Its secretion is regulated by SNS, and not by pituitary as in case of adrenal cortex. It stimulates sweating, heart beat and breathing rate.  It causes the dilation of coronary artery (supplying blood to the heart muscles), bronchioles (for increasing inspiratory volume) and pupil (for better vision).

Melatonin is produced by [2000]
  • a)
    thymus
  • b)
    skin
  • c)
    pituitary
  • d)
    pineal gland
Correct answer is option 'D'. Can you explain this answer?

Melatonin is secreted by pineal gland present between the cerebral hemispheres. Melatonin concentration in blood follows a diurnal cycle, it rises in the evening and drops at noon. Melatonin lightens skin colour in certain animals and regulates working of gonads.

Which one of the following hormones is a modified amino acid? [2004]
  • a)
    Epinephrine
  • b)
    Progesterone
  • c)
    Prostaglandin
  • d)
    Estrogen
Correct answer is option 'A'. Can you explain this answer?

Aniket Chawla answered
Epinephrine is synthesized from amino acid tyrosine. While estrogen and progesterone are modified steroids and prostaglandins are basically fat.

Toxic agents present in food which interfere with thyroxine synthesis lead to the development of: [2010]
  • a)
    toxic goitre
  • b)
    cretinism
  • c)
    simple goitre
  • d)
    thyrotoxicosis
Correct answer is option 'C'. Can you explain this answer?

Shounak Nair answered
Goitre is caused by deficiency of iodine in diet. Iodine is needed for the synthesis of thyroxine. Toxic agents present in food interfere with thyroxine synthesis and lead to goitre. 

Ovulation is stimulated by [1994]
  • a)
    LH
  • b)
    FSH
  • c)
    estrogen
  • d)
    progesterone
Correct answer is option 'A'. Can you explain this answer?

Srishti Sen answered
Luteinizing Hormone (LH) induces the Leideyg’s cells in males to produce testesterone and in female it causes ovulation and secretion of female sex hormone estrogen from mature ovarian follicle & progesterone by corpus luteum.

According to the “immunity theory” of ageing, the process starts with the gradual atrophy and disappearance of [1996]
  • a)
    thyroid
  • b)
    parthyroid
  • c)
    thymus
  • d)
      islets of Langerhans
Correct answer is option 'C'. Can you explain this answer?

According  to the immunity theory ageing occurs due to the loss of power of defence against the invasion of germs and pathogens. The process starts with the gradual atrophy and disappearance of the thymus gland during middle age.

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