The correct answer is option B: acquaint.

Explanation:
When it comes to enjoying life in a particular area, it is essential to familiarize oneself with the culture of that region. By becoming acquainted with the local customs, traditions, and way of life, individuals can better understand and appreciate the community they are in. This understanding can lead to a more fulfilling and enjoyable experience in the area.

Here is a detailed explanation of why option B, acquaint, is the correct answer:

1. Acquaint:
- Acquaint means to make oneself familiar with someone or something.
- In the context of the question, if you acquaint yourself with the culture of the area, it means you make yourself familiar with it.
- Acquainting yourself with the culture involves learning about the customs, traditions, language, food, art, and other aspects that define the local community.
- By doing so, you gain knowledge and understanding of the area's unique characteristics and can navigate daily life with greater ease and confidence.

2. Submit:
- Submit means to yield or surrender to a higher authority or power.
- In the context of the question, the word submit does not align with the concept of familiarizing oneself with the culture of an area.
- Familiarity with the culture is about learning and adapting, rather than surrendering or yielding to it.

3. Associate:
- Associate means to connect or link one thing or person with another.
- While associating with the local community is important for enjoying life in an area, it is not the primary action described in the question.
- Before associating with the community, it is crucial to acquaint oneself with the culture first.

4. Look after:
- Look after means to take care of or be responsible for someone or something.
- While it is important to take care of oneself and others, this phrase does not directly relate to familiarizing oneself with the culture of an area.
- Looking after oneself and others can be a consequence of being familiar with the culture, but it is not the action described in the question.

5. Instill into:
- Instill into means to gradually introduce or teach someone a particular belief, idea, or quality.
- While instilling cultural values into oneself is valuable, it does not capture the essence of familiarizing oneself with the culture.
- Familiarizing oneself with the culture involves actively seeking knowledge and understanding, rather than having it instilled by someone else.

In conclusion, the correct answer is option B: acquaint. Familiarizing oneself with the culture of an area is crucial for enjoying life there.