- Human Interface: The framework should focus on improving coordination and collaboration between human health, animal health, and environmental health sectors. This can be achieved through the establishment of multi-sectoral platforms and partnerships at the global, regional, and national levels.

- Early Warning Systems: Strengthening and expanding early warning systems for infectious diseases is crucial. This includes enhancing surveillance and reporting mechanisms for animal diseases, as well as improving disease detection and response capabilities in humans.

- Research and Innovation: Investing in research and innovation is vital for developing new tools, technologies, and approaches to prevent, detect, and respond to infectious diseases. This includes supporting research on zoonotic diseases, antimicrobial resistance, and the impact of environmental factors on disease transmission.

- Capacity Building: Building and strengthening the capacity of health systems, veterinary services, and environmental agencies is essential. This involves training healthcare workers, veterinarians, and other relevant personnel on disease prevention, surveillance, and response.

- Risk Assessment and Management: Conducting comprehensive risk assessments and implementing risk management strategies are key components of the framework. This includes identifying high-risk areas and populations, implementing targeted interventions, and promoting One Health approaches in risk management.

- Communication and Advocacy: Effective communication and advocacy efforts are crucial for raising awareness about the importance of One Health and infectious disease prevention. This involves engaging with policymakers, stakeholders, and the public to promote behavioral changes, policy reforms, and resource allocation for One Health initiatives.

- Sustainable Financing: Adequate and sustainable financing is necessary to support the implementation of the framework. This includes mobilizing domestic and international resources, exploring innovative financing mechanisms, and ensuring equitable distribution of funds for One Health programs.

- Global Cooperation: Enhancing global cooperation and coordination is essential for addressing infectious diseases at the animal-human-environment interface. This involves fostering partnerships between countries, sharing data and resources, and promoting knowledge exchange and best practices.

- Monitoring and Evaluation: Establishing robust monitoring and evaluation systems is critical for tracking progress and identifying areas for improvement. This includes developing indicators, conducting regular assessments, and using data to inform evidence-based decision-making.