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It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this.
P. CCA CC AUG G
Q. CCG CC AUG G
R. CCG CC AUG C
S. AAC GG AUG A
Which of the following sequence sets related to the above postulates is correct?
- a)P and Q
- b)P and R
- c)Q and S
- d)R and S
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
It has been reported that the first AUG is not the starting site for 5...
Concept:
- The control of gene expression includes fundamental mechanisms for regulating mRNA translation.
- Initiation, which entails the synthesis of an elongation-competent 80S ribosome at a start codon either by the ribosome scanning process or by a cap-independent mechanism, is the most important and rate-limiting step in translation.
Explanation:
- In most eukaryotic mRNAs, it is thought that translation initiates at the first AUG codon encountered by the 40S ribosomal subunit as it moves, or scans, 3' along the mRNA from the 5' m7G cap.
- Sequences flanking the AUG initiation codon are not random but fit a consensus sequence; in mammals, this sequence is GCCRCCaugG (Kozak sequence), and the most conserved nucleotides are the purine (R), usually A, in position -3 with respect to the AUG start codon and the guanine in position +4.
- The strong preference for A at position -3 and G at position +4 is also conserved in other animals and in plants and fungi.
- The sequence context of the first AUG codon, in particular the part located in the untranslated region, may modulate the efficiency with which it is recognized as a translation initiation codon.
- It is noteworthy that a large fraction of 5' UTRs contain upstream AUGs, from 15% to nearly 50% depending on the organism suggesting that the 'first AUG rule' predicted by the scanning model of ribosome start-site selection is disobeyed in a large number of cases.
- This implies that the 40S ribosomal subunit can sometimes bypass the most upstream AUG codon, possibly because its sequence context makes it a poor initiation codon, to initiate translation at a more distal AUG.
- With this mechanism, called 'leaky scanning', multiple different proteins can be obtained from the same mRNA
- Moreover, it has been calculated that the presence of an upstream AUG correlates with a long 5' UTR and with a 'weak' start codon context of the AUG that is usually used, whereas transcripts with an optimal start-codon context have short 5' UTRs without upstream AUGs , suggesting that upstream AUGs may have a role in keeping the basal translational level of a gene low.
Hence the correct answer is option 1
Most Upvoted Answer
It has been reported that the first AUG is not the starting site for 5...
Explanation:
Consensus Sequences:
- P. CCA CC AUG G
- Q. CCG CC AUG G
Explanation:
- The consensus sequences provided in the question are thought to be responsible for the ribosome skipping over one or more AUGs before finding the correct starting site for translation.
- In this case, the correct sequence set related to the postulates provided would be P and Q.
- This is because both sequences P and Q have the characteristic of having multiple AUGs and the ribosome skipping over some before initiating translation.
- Therefore, the correct answer is option 'A' which includes sequences P and Q as the related postulates.
Consensus Sequences:
- P. CCA CC AUG G
- Q. CCG CC AUG G
Explanation:
- The consensus sequences provided in the question are thought to be responsible for the ribosome skipping over one or more AUGs before finding the correct starting site for translation.
- In this case, the correct sequence set related to the postulates provided would be P and Q.
- This is because both sequences P and Q have the characteristic of having multiple AUGs and the ribosome skipping over some before initiating translation.
- Therefore, the correct answer is option 'A' which includes sequences P and Q as the related postulates.
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It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer?
Question Description
It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer?.
It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer?.
Solutions for It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? in English & in Hindi are available as part of our courses for Software Development.
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It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer?, a detailed solution for It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? has been provided alongside types of It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? theory, EduRev gives you an
ample number of questions to practice It has been reported that the first AUG is not the starting site for 5 to 10% of eukaryotic mRNAs having multiple AUGs. In these circumstances, the ribosome skips over one or more AUGs before coming across the advantageous one and commencing translation. The following consensus sequences are thought to be the cause of this. P. CCA CC AUG G Q. CCG CC AUG G R. CCG CC AUG C S. AAC GG AUG A Which of the following sequence sets related to the above postulates is correct?a)P and Qb)P and Rc)Q and Sd)R and SCorrect answer is option 'A'. Can you explain this answer? tests, examples and also practice Software Development tests.
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