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The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested:
P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA.
Q. Ribosomes are less active in recognizing circular mRNA.
R. eIF-4G and PABP promote this process.
S. Ribosomes can reinitiate translation without being disassembled.
- a)P and S
- b)Q and S
- c)P and R
- d)Q and R
Correct answer is option 'C'. Can you explain this answer?
Verified Answer
The presence of circular mRNAs for a specific protein in an eukaryotic...
Concept:
- Communication between the 5′ cap structure and 3′ poly(A) tail of eukaryotic mRNA results in the synergistic enhancement of translation.
- The cap and poly(A) tail binding proteins, eIF4E and Pab1p, mediate this effect in eukaryotesthrough their interactions with different parts of the translation factor eIF4G.
Explanation:
- Research studies have demonstrated thatceIF4E/eIF4G/Pab1p complex can for complexes with circularize capped, polyadenylated RNA.
- Efficient mRNA translation requires a series of protein–mRNA and protein–protein interactions.
- Structural elements of the eukaryotic mRNA, including the 5′ cap and 3′ poly(A) tail, are important determinants of these interactions.
- All eukaryotic mRNAs are modified at the 5′ end with a cap structure, which is recognized during translation initiation by the cap-binding protein eIF4E.
- A second factor, eIF4G, is associated with the mRNA as part of a complex with eIF4E and functions to recruit the 40S ribosome subunit through an interaction with eIF3 .
- Cap-dependent recruitment of the 40S ribosomal subunit to mRNA is subject to several cellular regulatory mechanisms.
- Phosphorylation of eIF4E can increase its affinity for the cap structure.
- Binding of the 4E-binding proteins (4E-BPs) can inhibit cap-dependent translation by preventing eIF4G binding to eIF4E
- Most eukaryotic mRNAs are also post-transcriptionally modified by the addition of a 3′ poly(A) tail.
- The poly(A) tail is known to be an important regulator of gene expression.
- Both cap- and poly(A) tail–dependent translation in Saccharomyces cerevisiae requires the translation initiation factor eIF4G.
- Initiation proteins contain a highly conserved binding site for eIF4E and a recently identified binding site for the poly(A) binding protein, Pab1p .
- In addition, these proteins have putative binding sites for eIF3 and RNA, the latter of which may span a region within the C-terminal domain that has homology to other RNA-binding proteins
Statement P:
eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA.
- Consider the explanation above thus this option is true, as translation initiation proteins contain a highly conserved binding site foreIF4E and a recently identified binding site for the poly(A) binding protein, Pab1p .
Statement Q:
Ribosomes are less active in recognizing circular mRNA.
- Consider the explanation above thus this option is not true, as research studies have demonstrated thatceIF4E/eIF4G/Pab1p complex can for complexes with circularize capped, polyadenylated RNA.
Statement R:
eIF-4G and PABP promote this process.
- Consider the explanation above thus this option istrue.
Statement S:
Ribosomes can reinitiate translation without being disassembled.
- Consider the explanation above thus this option is not true, as initiation is a two step process wherein the smaller unit with the aid of initiation factors binds with mRNA and then finally the bigger unit of ribosome joins the complex.
hence the correct answer is option 3
Most Upvoted Answer
The presence of circular mRNAs for a specific protein in an eukaryotic...
Explanation:
Presence of Circular mRNAs and Rapid Protein Synthesis:
- Circular mRNAs for a specific protein in an eukaryotic cell indicate a rapid rate of synthesis of that protein.
Mechanisms:
- P. eIF-4G and PABP promote this process through 5’-3’ interaction of mRNA.
- Q. Ribosomes are less active in recognizing circular mRNA.
- R. eIF-4G and PABP promote this process.
- S. Ribosomes can reinitiate translation without being disassembled.
Correct Answer Justification (C - P and R):
- Choice P states that eIF-4G and PABP play a role in promoting the rapid synthesis of proteins by interacting with mRNA in a specific way.
- Choice R also mentions the involvement of eIF-4G and PABP in promoting this process.
- Therefore, the correct answer is option 'C' (P and R) as both choices emphasize the role of these factors in enhancing protein synthesis efficiency.
In conclusion, the presence of circular mRNAs for a specific protein in an eukaryotic cell points towards a rapid rate of protein synthesis, with mechanisms involving factors like eIF-4G and PABP playing a crucial role in this process.
Presence of Circular mRNAs and Rapid Protein Synthesis:
- Circular mRNAs for a specific protein in an eukaryotic cell indicate a rapid rate of synthesis of that protein.
Mechanisms:
- P. eIF-4G and PABP promote this process through 5’-3’ interaction of mRNA.
- Q. Ribosomes are less active in recognizing circular mRNA.
- R. eIF-4G and PABP promote this process.
- S. Ribosomes can reinitiate translation without being disassembled.
Correct Answer Justification (C - P and R):
- Choice P states that eIF-4G and PABP play a role in promoting the rapid synthesis of proteins by interacting with mRNA in a specific way.
- Choice R also mentions the involvement of eIF-4G and PABP in promoting this process.
- Therefore, the correct answer is option 'C' (P and R) as both choices emphasize the role of these factors in enhancing protein synthesis efficiency.
In conclusion, the presence of circular mRNAs for a specific protein in an eukaryotic cell points towards a rapid rate of protein synthesis, with mechanisms involving factors like eIF-4G and PABP playing a crucial role in this process.
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The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer?
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The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer?.
The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer?.
Solutions for The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer? in English & in Hindi are available as part of our courses for Software Development.
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ample number of questions to practice The presence of circular mRNAs for a specific protein in an eukaryotic cell reflects a rapid rate of synthesis of that protein. The following mechanisms are suggested: P. eIF-4G and PABP promote this process through 5’- 3’ interaction of mRNA. Q. Ribosomes are less active in recognizing circular mRNA. R. eIF-4G and PABP promote this process. S. Ribosomes can reinitiate translation without being disassembled. a)P and Sb)Q and Sc)P and Rd)Q and RCorrect answer is option 'C'. Can you explain this answer? tests, examples and also practice Software Development tests.
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