During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer?

Explore Courses UPSC Exam UPSC Test Series Free Notes EduRev Infinity

Open App

Software Development Exam > Software Development Questions > During heat shock, mammalian cells shut down ...

During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular  regulations that could explain the phenomenon are:

 A. mRNA  of all proteins except those of HSPs  undergo degradation during heat shock 

B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e.

C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES

D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation.

Which of the following sets is correct:

a)
A and B
b)
B and C
c)
A and C
d)
A and D

Correct answer is option 'B'. Can you explain this answer?

Join for Free

Join for Free

Verified Answer

During heat shock, mammalian cells shut down global protein synthesis ...

Concept:

The eukaryotic heat shock response is an ancient and highly conserved transcriptional program that results in the immediate synthesis of a battery of cytoprotective genes in the presence of thermal and other environmental stresses.
Many of these genes encode molecular chaperones, powerful protein remodelers with the capacity to shield, fold, or unfold substrates in a context-dependent manner.

Explanation:

Fig 1: Molecular events of heat shock protein induction

Class

I	HSP genes & chaperones Rapid & continuous induction Increase pause release
II	Cytoskeletal genes Rapid & transient induction Increase pause release
III	Apoptotic genes Late induction Increase pause release
IV	Metabolism & Cell genes Rapid & continuous repression Decrease pause release
V	mRNA processing genes Late repression Decrease pause release

the genome-wide transcriptional response to heat shock in mammals is
rapid and dynamic and results in induction of several
hundred and repression of several thousand genes.
Heat shock factor 1 (HSF1), the ‘‘master regulator’’
of the HSR, controls only a fraction of heat shock induced genes and does so by increasing RNA polymerase II release from promoter-proximal pause.
1,500 genes are up- and 8,000 are downregulated during the first hour of heat shock.
HSF1 induces heat shock protein genes by increasing promoter-proximal pause release.
Upon heat shock, SRF transiently induces immediate-early cytoskeletal genes.
Broad repression during heat shock in mammals occurs by inhibiting pause release.

Statement A:

mRNA  of all proteins except those of HSPs  undergo degradation during heat shock 

Consider the explanation above thus this option is not true

Statement B:

Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e.

Consider the explanation above thus this option is true

Statement C:

Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES

Consider the explanation above thus this option is true

Statement D:

HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation.

Consider the explanation above thus this option is not true

hence the correct answer is option 1

View all questions of this test

Most Upvoted Answer

During heat shock, mammalian cells shut down global protein synthesis ...

Explanation:

Cap-dependent translation affected during heat shock
- Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e.
- This leads to a shutdown of global protein synthesis, except for the translation of heat shock proteins (HSPs).
- Denaturation of eIF-4e disrupts the initiation of translation for most mRNAs, while HSP mRNAs can still be translated via alternative mechanisms.
Therefore, option B is correct because it explains how the shutdown of global protein synthesis occurs during heat shock while still allowing for the translation of HSPs.

Answered by Eduskill Classes · View profile

View all answers Start learning for free

Explore Courses for Software Development exam

Similar Software Development Doubts

During the elongation step of protein synthesis, translocation moves the mRNA and the peptidyl tRNA by one codon through the ribosome. Translocation in E. coli involves GTP and EF-G; however, in vitro, translocation can take place independently of GTP and EF-G. Based on these observations, the following hypothesis can be made: A. the molecular mechanism of translocation in vitro is completely different from that in Vivo translocation activity is independent of GTP hydrolysis B. translocation activity is completely dependent on GTP and EF-G C. translocation activity is inherent in ribosomes however the rate of translocation in vivo is enhanced significantly in the presence of GTP and EF-G Which of the following combinations is correct

View answer

Internal ribosome entry site IRES presence in mRNA aids with

View answer

Consider the following transaction code:BEGIN TRANSACTION;UPDATE products SET price = price * 1.1 WHERE category = Electronics;COMMIT;What will be the outcome of this transaction?

View answer

In addition to polymerase activity, reverse transcriptase also functions as a ribonuclease. The following facts involve ribonuclease activity

View answer

Consider the following transaction code:BEGIN TRANSACTION;SELECT COUNT() FROM products WHERE category = Clothing;UPDATE products SET price = price 0.9 WHERE category = Clothing;COMMIT;

View answer

Top Courses for Software DevelopmentView all

How to become an Expert of MS Excel

ChatGPT for Everything: How to Use ChatGPT?

Basics of Python

GATE Computer Science Engineering(CSE) 2025 Mock Test Series

Company Wise Preparation

Top Courses for Software Development

View all

During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer?

Share with a Friend

Answer this doubt

Question Description
During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer?.

Solutions for During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer? in English & in Hindi are available as part of our courses for Software Development. Download more important topics, notes, lectures and mock test series for Software Development Exam by signing up for free.

Here you can find the meaning of During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer? defined & explained in the simplest way possible. Besides giving the explanation of During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer?, a detailed solution for During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer? has been provided alongside types of During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer? theory, EduRev gives you an ample number of questions to practice During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular regulations that could explain the phenomenon are: A. mRNA of all proteins except those of HSPs undergo degradation during heat shock B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e. C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation. Which of the following sets is correct: a)A and Bb)B and Cc)A and Cd)A and DCorrect answer is option 'B'. Can you explain this answer? tests, examples and also practice Software Development tests.

Explore Courses for Software Development exam