The hyposecretion of pituitary hormone cause :-a)Cretinismb)Diabetes i...
Diabetes insipidus (DI) is a condition caused by hyposecretion of, or insensitivity to the effects of, antidiuretic hormone (ADH), also known as arginine vasopressin (AVP). ADH is synthesised in the hypothalamus and transported as neurosecretory vesicles to the posterior pituitary. There it is released into the circulation, governed by plasma osmolality. Its deficiency or failure to act causes an inability to concentrate urine in the distal renal tubules, leading to the passage of copious volumes of dilute urine. Usually the person with this condition passes >3 litres/24 hours of low osmolality (<300 mOsmol/kg) urine.
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The hyposecretion of pituitary hormone cause :-a)Cretinismb)Diabetes i...
The correct answer is option 'B': Diabetes insipidus.
Explanation:
Hyposecretion of pituitary hormones can lead to various health conditions. One such condition is diabetes insipidus. Let's understand the role of the pituitary gland and how hyposecretion can lead to diabetes insipidus.
1. Role of the pituitary gland:
The pituitary gland, located at the base of the brain, is often referred to as the "master gland" as it controls the secretion of several hormones that regulate various bodily functions. It consists of two main parts: the anterior pituitary and the posterior pituitary.
2. Hormones secreted by the posterior pituitary:
The posterior pituitary gland releases two important hormones: antidiuretic hormone (ADH) and oxytocin. ADH, also known as vasopressin, plays a crucial role in regulating water balance in the body.
3. Function of antidiuretic hormone (ADH):
ADH acts on the kidneys to regulate the fluid balance by controlling the reabsorption of water from the urine. It increases the permeability of the renal collecting ducts, allowing water to be reabsorbed back into the bloodstream. This mechanism helps in maintaining the body's water balance and preventing excessive urine production.
4. Hyposecretion of antidiuretic hormone (ADH):
When there is a hyposecretion or insufficient production of ADH by the posterior pituitary gland, it leads to a condition called diabetes insipidus. This condition is characterized by excessive thirst and urine production, as the body is unable to properly regulate water balance.
5. Symptoms of diabetes insipidus:
- Excessive thirst (polydipsia)
- Frequent urination, especially in large volumes (polyuria)
- Diluted urine
- Dehydration
- Fatigue
- Irritability
6. Causes of diabetes insipidus:
Diabetes insipidus can be caused by different factors:
- Central diabetes insipidus: It occurs due to the inadequate production or release of ADH by the pituitary gland.
- Nephrogenic diabetes insipidus: In this condition, the kidneys are unable to respond to ADH, resulting in excessive urine production.
In conclusion, the hyposecretion of pituitary hormone leads to diabetes insipidus, a condition characterized by excessive thirst and urine production. This occurs when there is inadequate production or release of antidiuretic hormone (ADH) by the posterior pituitary gland.
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