Conn's disease is due to hypersecretion of aldosterone.

Explanation:
Conn's disease, also known as primary hyperaldosteronism, is a condition characterized by the overproduction of aldosterone hormone by the adrenal glands. Aldosterone is a hormone secreted by the adrenal cortex that plays a vital role in regulating the balance of salt and water in the body. It acts on the kidneys, promoting the reabsorption of sodium and the excretion of potassium.

Causes of Conn's Disease:
The most common cause of Conn's disease is the presence of an adrenal adenoma, a benign tumor in one of the adrenal glands. This adenoma leads to the excessive production and release of aldosterone. In some cases, Conn's disease may also be caused by bilateral adrenal hyperplasia, where both adrenal glands become enlarged and produce excessive aldosterone.

Effects of Hyperaldosteronism:
The hypersecretion of aldosterone in Conn's disease leads to several physiological effects, including:
1. Increased Sodium Retention: Aldosterone promotes the reabsorption of sodium in the kidneys, leading to increased levels of sodium in the blood.
2. Potassium Excretion: As sodium is retained, potassium is excreted, causing low levels of potassium in the blood.
3. Fluid Imbalance: The increase in sodium retention leads to water retention, resulting in an expansion of blood volume and increased blood pressure.
4. Hypokalemia: Low levels of potassium can cause muscle weakness, cramps, and irregular heart rhythms.

Diagnosis and Treatment:
The diagnosis of Conn's disease involves blood tests to measure aldosterone and renin levels, as well as imaging studies such as CT scan or MRI to identify any adrenal tumors. Treatment options include medications to control blood pressure and correct potassium imbalances, as well as surgical removal of the adrenal adenoma or hyperplasia.

Conclusion:
In summary, Conn's disease is a condition characterized by the hypersecretion of aldosterone due to adrenal adenoma or bilateral adrenal hyperplasia. This excessive production of aldosterone leads to sodium retention, potassium excretion, fluid imbalance, and hypokalemia. Proper diagnosis and treatment are essential to manage the symptoms and prevent complications associated with this condition.