Q.1. Match the following columns and select the correct option. (2020)
The antidiuretic hormone released by the pituitary gland stimulates reabsorption of water by the kidneys. The deficiency of this hormone causes increased urine production, a condition called diabetes insipidus. Graves disease is an immune system disorder that results in the overproduction of thyroid hormones. Addison's disease is caused by a deficiency of the hormones secreted by the adrenal cortex. Pancreas is a composite gland which acts as both exocrine and endocrine gland. The deficiency of insulin, a hormone secreted by the pancreas, causes a complex disorder called diabetes mellitus which is associated with loss of glucose through urine and formation of harmful compounds known as ketone bodies.
Q.2. Select the correct statement. (2020)
(a) Insulin acts on pancreatic cells and adipocytes.
(b) Insulin is associated with hyperglycemia.
(c) Glucocorticoids stimulate gluconeogenesis.
(d) Glucagon is associated with hypoglycemia.
(a) Insulin acts mainly on hepatocytes and adipocytes (cells of adipose tissue), and enhances cellular glucose uptake and utilisation.
(b) Glucagon acts mainly on the liver cells (hepatocytes) and stimulates glycogenolysis resulting in an increased blood sugar (hyperglycemia).
(c) Glucocorticoids stimulate, gluconeogenesis, lipolysis and proteolysis; and inhibit cellular uptake and utilisation of amino acids.
(d) Glucagon hormone stimulates the process of gluconeogenesis which also contributes to hyperglycemia.
Q.3. How does steroid hormone influence the cellular activities? (2019)
(a) Using aquaporin channels ‘as second messenger'
(b) Changing the permeability of the cell membrane
(c) Binding to DNA and forming a gene- hormone complex
(d) Activating cyclic AMP located on the cell membrane
Steroid hormones are lipid-soluble and easily pass through the cell membrane of a target cell into the cytoplasm where they bind to specific intracellular receptors (proteins) to form a hormone receptor complex that enters the nucleus. In the nucleus, hormone which interact with intracellular receptors mostly regulate gene expression or chromosome function by the interaction of hormone-receptor complex with the genome. Biochemical actions result in physiological and developmental effects.
Q.4. Match the following hormones with their respective disease:
|(A) Insulin||(i) Addison’s disease|
|(B) Thyroxin||(ii) Diabetes insipidus|
|(C) Corticoids||(iii) Acromegaly|
|(D) Growth hormone||(iv) Goitre|
|(v) Diabetes mellitus|
Select the correct option. (2019)
Q.5. Identify A, B and C in the diagramatic representation of the mechanism of hormone action.
Select the correct option from the following: (2019)
(a) A-Steroid Hormone; B-IIormone-receptor Complex, C-Protein
(b) A-Protein Hormone, B-Rcceptor; C-Cyclic AMP
(c) A-Steroid Hormone; B-Receptor, C - Second Messenger
(d) A-Protein Hormone; B-Cyclic AMP, C-Honnone-receptor Complex
Q.6. Which of the following is an amino acid derived hormone? (2018)
Epinephrine which triggers the flight or fight response is derived from amino acid tyrosine, h is synthesised in the medulla of the adrenal glands.
Q.7. Which of the following hormones can play a significant role in osteoporosis? (2018)
(a) Aldosterone and prolactin
(b) Progesterone and aldosterone
(c) Estrogen and parathyroid hormone
(d) Parathyroid hormone and prolactin
Estrogen plays a central role in control of bone strength. In a healthy individual, bone mass is maintained by balanced activity of bone forming osteoblasts and bone resorbing osteoclasts. Both these cell types are reported to respond to estrogen. Estrogen promotes the activity of osteoblast and induces osteoclast apoptosis. After menopause the level of this hormone declines. Hence, in an ageing female osteoporosis occurs. Parathormone promotes mobilisation of calcium from bone into blood. Excessive activity of parathormone causes demineralisation of bone leading to osteoporosis.
Q.8. GnRH, a hypothalamic hormone, needed in reproduction, acts on (2017)
(a) Anterior pituitary gland and stimulates secretion of LH and FSH
(b) Posterior pituitary gland and stimulates secretion of oxytocin and FSH
(c) Posterior pituitary gland and stimulates secretion of LH and relaxin
(d) Anterior pituitary gland and stimulates secretion of LH and oxytocin.
Gonadotropin releasing hormone (GnRH) is secreted by the hypothalamus which stimulates the anterior lobe of pituitary gland to secrete lutcinising hormone (LH) and Follicle Stimulating Hormone (FSH).
Q.9. Hypersecretion of growth hormone in adults does not cause further increase in height, because (2017)
(a) Epiphyseal plates close after adolescence
(b) Bones loose their sensitivity to growth hormone in adults
(c) Muscle fibres do not grow in size after birth
(d) Growth hormone becomes inactive in adults.
Epiphyseal plate is a hyaline cartilage plate in the metaphysis at each end of long bone. It is part of long bone where new bone growth lakes place. In adults, elevated levels of GH results in acromegaly where no increase in height occurs because of ossified epiphyseal plate.
Q.10. A temporary endocrine gland in the human body is (2017)
(a) Corpus cardiacum
(b) Corpus luteum
(c) Corpus allatum
(d) Pineal gland.
Corpus lutcum is a temporary endocrine gland in human females.
It secretes progesterone which stimulates the uterine glands to produce increased amount of watery mucus and is also essential for maintenance of endothelium. In absence of fertilisation, corpus lutcum disintegrate leading to menstruation.
Q.11. Graves’ disease is caused due to (2016)
(a) Hyposecrction of thyroid gland
(b) Hypersecretion of thyroid gland
(c) Hyposecrction of adrenal gland
(d) Hypersecretion of adrenal gland.
Exophthalmic goitre or Graves’ disease is a thyroid enlargement (goitre) in which the thyroid secretes excessive amount of thyroid hormone. It is characterised by exophthalmia (protrusion of eye balls because of fluid accumulation behind them), loss of weight, slightly rise in the body temperature, excitability, rapid heart beat, nervousness and restlessness.
Graves' disease symptoms
Q.12. Name a peptide hormone which acts mainly on hepatocytes, adipocytes and enhances cellular glucose uptake and utilisation. (2016)
Insulin is a peptide hormone, secreted by the β cells of the islets of Langerhans in the pancreas, that promotes the uptake of glucose by body cells, particularly in the liver (hepatocytes) and muscles (adipocytes) and thereby controls its concentration in the blood.
Q.13. The posterior pituitary gland is not a true endocrine gland because (2016)
(a) It is provided with a duct
(b) It only stores and releases hormones
(c) It is under the regulation of hypothalamus
(d) It secretes enzymes.
Posterior lobe of pituitary gland does not secrete any hormone. Its hormones are synthesised by the hypothalamus. It only stores and releases these hormones. Hence, it cannot be considered as true gland.
Q.14. Which of the following pairs of hormones are not antagonistic (having opposite effects) to each other? (2016)
(a) Parathormone – Calcitonin
(b) Insulin – Glucagon
(c) Aldosterone – Atrial Natriuretic Factor
(d) Relaxin – Inhibin
Calcitonin exerts its effects by interacting with target cells, primarily in bone and kidney. The actions of PTH and calcitonin are antagonistic on bone resorption but synergistic on decreasing the renal tubular reabsorption of phosphorus. Insulin and glucagon work synergistically to keep blood glucose concentrations normal. An elevated blood glucose concentration results in the secretion of insulin and glucose is transported into body cells. Aldosterone secretion may be inhibited by potassium depletion, inhibitors of the reninangiotensin system, dopamine and atrial natriuretic factor.
The latter appears to be an important physiological regulator of aldosterone secretion. ANF inhibits basal, ACTH, Angiotensin II and potassiumstimulated aldosterone production in vitro by a direct action on the adrenal gland. Inhibin is a hormone secreted by granulosa cells of the ovary which inhibit the secretion of FSH (Follicle Stimulating Hormone) whereas relaxin produced by ovary and placenta at the time of childbirth to softens the ligament in the pelvis and widens the cervix.
Q.15. Changes in GnRH pulse frequency in females is controlled by circulating levels of (2016)
(a) Estrogen and progesterone
(b) Estrogen and inhibin
(c) Progesterone only
(d) Progesterone and inhibin
At the pituitary, GnRH stimulates the synthesis and secretion of the gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from progesterone and estrogens. Low-frequency GnRH pulses are required for FSH release, whereas highfrequency GnRH pulses stimulate LH pulses in a one to one manner.
Q.16. Identify the correct statement on 'inhibin' (2016)
(a) Inhibits the secretion of LH, FSH and Prolactin.
(b) Is produced by granulose cells in ovary and inhibits the secretion of FSH.
(c) Is produced by granulose cells in ovary and inhibits the secretion of LH.
(d) Is produced by nurse cells in testes and inhibits the secretion of LH.
In both females and males, inhibin inhibits FSH production. In females, FSH stimulates the secretion of inhibin from the granulosa cells of the ovarian follicles in the ovaries. In turn, inhibin suppresses FSH. In males, androgens stimulate inhibin production. It is secreted from the Sertoli cells, located in the seminiferous tubules inside the testes.
Q.17. A chemical signal that has both endocrine and neural roles is? (2015)
Epinephrine has two role as a hormone and as a neurotransmitter.
Q.18. Which one of the following hormones is not involved in sugar metabolism? (2015)
Aldosterone is produced by adrenal cortex and plays an important role in the regulation of Na+ and K+ levels in body.
Q.19. Which one of the following hormones though synthesised elsewhere is stored and released by the master gland? (2015)
(a) Luteinizing hormone
(c) Melanocyte stimulating hormone
(d) Antidiuretic hormone
ADH (Antidiuretic hormone) and oxytocin are produced by hypothalamus and stored in posterior pituitary.
Q.20. Identify the hormone with its correct matching of source and function: (2014)
(a) Oxytocin - posterior pituitary, growth and maintenance of mammary glands.
(b) Melatonin - pineal gland, regulates the normal rhythm of sleepwake cycle.
(c) Progesterone - corpus-luteum, stimulatiuon of growth and activities of female secondary sex organs.
(d) Atrial natriuretic factor - ventricular wall increases the blood pressure.
Oxytocin, a neurohypophysial hormone, is produced by the hypothalamus and stored and secreted by the posterior pituitary gland. It stimulates contractions of the smooth muscle tissue in the wall of the uterus during childbirth. Progesterone is a female hormone produced by the ovaries during release of a mature egg from an ovary (ovulation). Progesterone helps prepare the lining of the uterus (endometrium) to receive the egg if it becomes fertilized by a sperm. If the egg is not fertilized, progesterone levels drop and menstrual bleeding begins. Atrial natriuretic factor is a hormonal substance produced by the right atrium of the heart that stimulates the excretion of sodium and water by the kidneys and helps regulate blood pressure.
Q.21. Fight-or-flight reactions cause activation of: (2014)
(a) The parathyroid glands, leading to increased metabolic rate.
(b) The kidney, leading to suppression of reninangiotensin-aldosterone pathway.
(c) The adrenal medulla, leading to increased secretion of epinephrine and norepinephrene.
(d) The pancreas leading to a reduction in the blood sugar levels.
Adrenal Medulla is called emergency gland and secretes adrenaline (Epinephrine) and nor-adrenaline (nor-epinephrine) hormones. Adrenaline (epinephrine) is commonly called as ‘emergency hormone’ or 3F – hormone (For fear, fight & flight). It stimulates sweating, heart beat and breathing rate. It causes the dilation of coronary artery (supplying blood to the heart muscles), bronchioles (for increasing inspiratory volume) and pupil (for better vision).