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Gabriel Phthalimide Synthesis Mechanism Video Lecture | Organic Chemistry for NEET
FAQs on Gabriel Phthalimide Synthesis Mechanism Video Lecture - Organic Chemistry for NEET
| 1. What is the synthesis mechanism of Gabriel phthalimide? |  |
The synthesis mechanism of Gabriel phthalimide involves the reaction between phthalimide and an alkyl halide in the presence of a strong base, such as potassium hydroxide or sodium hydroxide. The alkyl halide reacts with the phthalimide to form an N-alkyl phthalimide intermediate, which is then treated with hydrazine to remove the phthalimide protecting group and generate the desired Gabriel phthalimide product.
| 2. What are the starting materials required for Gabriel phthalimide synthesis? | |
The starting materials required for Gabriel phthalimide synthesis are phthalimide and an alkyl halide. Phthalimide serves as the nitrogen source, providing the phthalimide protecting group that can be removed later in the reaction. The alkyl halide, such as alkyl bromide or alkyl chloride, serves as the alkylating agent and reacts with phthalimide to form the N-alkyl phthalimide intermediate.
| 3. What is the role of a strong base in the Gabriel phthalimide synthesis? | |
A strong base, such as potassium hydroxide or sodium hydroxide, is used in the Gabriel phthalimide synthesis to deprotonate the phthalimide nitrogen and facilitate the nucleophilic substitution reaction with the alkyl halide. The strong base also helps in the removal of the phthalimide protecting group in the final step of the synthesis.
| 4. How does hydrazine remove the phthalimide protecting group in Gabriel phthalimide synthesis? | |
Hydrazine is used in Gabriel phthalimide synthesis to remove the phthalimide protecting group. The reaction between the N-alkyl phthalimide intermediate and hydrazine results in the formation of a hydrazone intermediate. This hydrazone intermediate is unstable and undergoes spontaneous rearrangement to release phthalimide and generate the desired Gabriel phthalimide product.
| 5. Can Gabriel phthalimide synthesis be used for the synthesis of other compounds? | |
Yes, Gabriel phthalimide synthesis can be used for the synthesis of other compounds. The Gabriel phthalimide product can serve as a versatile intermediate in various organic synthesis reactions, such as the synthesis of primary amines or the preparation of other nitrogen-containing compounds. The Gabriel synthesis has found applications in the pharmaceutical and agrochemical industries for the preparation of diverse molecules.
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