Skeletal muscles consist of muscle bundles (fascicles) held together by fascia, containing muscle fibres lined by sarcolemma and rich in myofibrils with alternating dark and light bands due to actin and myosin proteins. The sarcoplasmic reticulum stores calcium ions, and the muscle fibre is multinucleated.
Diagrammatic cross sectional view of a muscle showing muscle bundles and muscle fibres
The light I-band contains actin (thin filaments) and is bisected by a Z-line, while the dark A-band contains myosin (thick filaments) with an M-line at its center. The alternating arrangement of A and I bands forms the myofibrils. The segment between two Z-lines is a sarcomere, the functional unit of contraction. In a resting state, the thin filaments partially overlap the thick filaments, leaving a central H-zone in the thick filaments.
Diagrammatic representation of (a) anatomy of a muscle fibre showing a sarcomere (b) a sarcomere
Each actin filament consists of two helically wound F-actins with tropomyosin and troponin proteins, where troponin masks myosin-binding sites. Each myosin filament is made of meromyosins, with the globular head (HMM) acting as an ATPase and containing binding sites for ATP and actin, forming cross arms.
(a) An actin (thin) filament (b) Myosin monomer (Meromyosin)
Stages in cross bridge formation, rotation of head and breaking of cross bridge
The axial skeleton consists of 80 bones along the body’s main axis, including the skull, vertebral column, sternum, and ribs. The skull has 22 bones, with 8 cranial bones protecting the brain and 14 facial bones forming the front. The hyoid bone is located at the base of the buccal cavity, and each ear contains three ear ossicles (malleus, incus, stapes). The vertebral column has 26 vertebrae, divided into cervical, thoracic, lumbar, sacral, and coccygeal regions, protecting the spinal cord. The sternum is a flat bone, and the rib cage consists of 12 pairs of ribs, with 7 true ribs, 3 false ribs, and 2 floating ribs, all contributing to the thoracic structure.
Diagrammatic view of human skull
Vertebral column (right lateral view)
Ribs and rib cage
The appendicular skeleton consists of the bones of the limbs and their girdles, with each limb containing 30 bones. The forelimb includes the humerus, radius, ulna, 8 carpals, 5 metacarpals, and 14 phalanges. The hind limb consists of the femur, tibia, fibula, 7 tarsals, 5 metatarsals, and 14 phalanges, with the patella (kneecap) covering the knee. The pectoral girdle, made up of the clavicle and scapula, connects the upper limbs to the axial skeleton, while the pelvic girdle, composed of two coxal bones formed by the fusion of ilium, ischium, and pubis, connects the lower limbs. The pelvic bones meet at the pubic symphysis.
Right pectoral girdle and upper arm. (frontal view)
Right pelvic girdle and lower limb bones (frontal view)
Q1: Which of the following statements are correct regarding skeletal muscle? (NEET 2023)
A. Muscle bundles are held together by collagenous connective tissue layer called fascicle.
B. Sarcoplasmic reticulum of muscle fibre is a store house of calcium ions.
C. Striated appearance of skeletal muscle fibre is due to distribution pattern of actin and myosin proteins.
D. M line is considered as functional unit of contraction called sarcomere.
Choose the most appropriate answer from the options given below:
(a) A, B and C only
(b) B and C only
(c) A, C and D only
(d) C and D only
Ans: (b)
Option (B) is the correct answer because statements B and C are only correct statements while A and D are incorrect statements.Muscle bundles are held together by collagenous connective tissue layer called fascia. Muscle bundles are called fascicles. The portion of the myofibril between two successive ‘Z’ lines is considered as functional unit of contraction called sarcomere.
Q2: According to the sliding filament theory: (NEET 2022 Phase 2)
(a) The actin filaments slide away from A-band resulting in shortening of sarcomere.
(b) Actin and myosin filaments slide over each other to increase the length of the sarcomere.
(c) Length of A-band does not change
(d) I-band increases in length.
Ans: (c)
Q3: Select the correct option. (NEET 2019)
(a) There are seven pairs of vertebrosternal, three pairs of vertebrochondral and two pairs of vertebral ribs.
(b) 8th, 9th and 10th pairs of ribs articulate directly with the sternum.
(c) 11th and 12th pairs of ribs are connected to the sternum with the help of hyaline cartilage.
(d) Each rib is a flat thin bone and all the ribs are connected dorsally to the thoracic vertebrae and ventrally to the sternum.
Ans: (a)Seven pairs of Ribs are vertebrosternal while 8th, 9th and 10th pair of ribs are vertebrochondral and the last 11th, 12th pair are vertebral ribs.
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1. What is the basic structure of skeletal muscle? |
2. What is a sarcomere and its function in muscle contraction? |
3. How are contractile proteins structured in skeletal muscle? |
4. What is the mechanism of muscle contraction? |
5. What are the differences between the axial and appendicular skeleton? |
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