All questions of Chapter 6 - Molecular Basis of Inheritance for NEET Exam

Transformation was discovered by:                    [2014]
  • a)
    Meselson and Stahl
  • b)
    Hershey and Chase
  • c)
    Griffith
  • d)
    Watson and Crick
Correct answer is option 'C'. Can you explain this answer?

Yash Saha answered
(c) Frederick Griffith (in 1928), a British Medical officer described the phenomenon of bacterial transformation. He carried out experiment with Streptococcus pneumoniae (bacterium causing pneumonia) which is used to infect mice. By using S Strain (heat killed) and R strain (live) it was concluded that R strain has been transformed by some material of S strain which makes R strain virulent and enable to synthesize smooth polysachharide.

Which one of the following is wrongly matched?                [2014]
  • a)
    Transcription – Writing information from DNA to tRNA.
  • b)
    Translation – Using information in mRNA to make protein
  • c)
    Repressor protein – Binds to operator to stop enzyme synthesis.
  • d)
    Operon – Structural genes, operator and promoter
Correct answer is option 'A'. Can you explain this answer?

Aman Sharma answered
(a) Process of copying genetic information from DNA to RNA is called transcription. At a time only one DNA strand is being transcribed into RNA. The strand of DNA with polarity 3' → 5' act as template strand and the DNA strand with polarity 5' → 3' act as coding strand.

Commonly used vectors for human genome sequencing are:                        [2014]
  • a)
    T-DNA
  • b)
    BAC and YAC
  • c)
    Expression Vectors
  • d)
    T/A Cloning Vectors
Correct answer is option 'B'. Can you explain this answer?

Anirudh Datta answered
(b) Human genome sequencing is a process that determines the complete DNA sequence of an organism's genome at a single time. This requires sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Commonly used vectors for human genome sequencing are BAC (Bacterial artificial chromosomes) and YAC (Yeast artificial chromosomes).

An abnormal human baby with 'XXX' sex chromosomes was born due to
  • a)
    formation of abnormal sperms in the father
  • b)
    formation of abnormal ova in the mother
  • c)
    fusion of two ova and one sperm
  • d)
    fusion of two sperms and one ovum
Correct answer is option 'B'. Can you explain this answer?

Alleles are different molecular forms of a gene, representing altemate forms of a given character.
Height of a pea plant-T for tallness and t for dwarfness.
T and t are altemate forms for given character of height.
Heterozygotes and homozygotes refers to inheritance of two different and similar travels for a character respectively.

A complex of ribosomes attached to a single strand of RNA is known as                 [2016]
  • a)
    Polysome
  • b)
    Polymer
  • c)
    Polypeptide
  • d)
    Okazaki fragment
Correct answer is option 'A'. Can you explain this answer?

Dipika Das answered
(a) A polysome or polyribosome is a complex of an mRNA molecule and two or more ribosomes, which is formed during the active translation process. They were initially named as ergosomes in 1963. However, further research by Jonathan Warner and Alex Rich characterized polysome.

In a DNA percentage of thymine is 20% then what will be the percentage of guanine?
[2002]
  • a)
    20%
  • b)
    40%
  • c)
    30%
  • d)
    60%
Correct answer is option 'C'. Can you explain this answer?

Tejas Chavan answered
According to Chargaff's rule, the ratio of purine bases to pyrimidine bases is equal.
A = T, C = G.
If T is 20% then A is 20% and C and G are 30%, 30%.

In E.coli during lactose metabolism repressor binds to
[2002]
  • a)
    regulator gene
  • b)
    operator gene
  • c)
    structural gene
  • d)
    promoter gene
Correct answer is option 'B'. Can you explain this answer?

Vaibhav Basu answered
Regulator gene for ms a biochemical for suppressing the activity of operator gene. Promoter gene is the gene which provides point of attachment to RNA polymerase required for transcription of structural genes. Structural genes are genes which transcribe m RNA for polypeptide synthesis.

The number of base substitution possible in amino acid codons is
[1994]
  • a)
    261
  • b)
    264
  • c)
    535
  • d)
    549
Correct answer is option 'D'. Can you explain this answer?

Sarthak Saini answered
Codons are 6 in number. Each codon possess 3 bases, each of which can undergo transition and transversion. (1 × 32 = 549)

Which of the following important biochemical reactions in living systems is catalyzed by a ribozyme?
a)Formation of peptide bond
b)Repair of DNA
c)Electron transfer chain
d)Organization of MTOC during cell divison
Correct answer is option 'A'. Can you explain this answer?

Gaurav Kumar answered
In prokaryotes (bacteria) the 23srRNA  of the larger subunit of ribosome is the enzyme ribozyme that catalyzes peptide bond formation.
Hence, the correct option is A.
NCERT Reference: Page no. 115 of topic “6.7 TRANSLATION” of chapter 6.

Who proved that DNA is basic genetic material?
[1993]
  • a)
    Griffith
  • b)
    Watson
  • c)
    Boveri and Sutton
  • d)
    Hershey and Chase
Correct answer is option 'D'. Can you explain this answer?

Preeti Iyer answered
Hershey and Chase did two experiments to prove that DNA is the carrier of the genetic information. First, they grew phages (viruses which infect bacteria) in a medium containing radioactive sulphur (35^S). This marked all the proteins of the phage (the hull) radioactive. They then used this phage to infect bacteria.

Frequency of an allele in a isolated population may change due to
[2001]
  • a)
    genetic Drift
  • b)
    gene flow
  • c)
    mutation
  • d)
    natural selection
Correct answer is option 'A'. Can you explain this answer?

Soumya Ahuja answered
Mutations are sudden inheritable variations which develop in the genetic system. Natural selection operates through differential  reproduction.

How many base pairs (bp) are found in the haploid genome of humans?
[1999]
  • a)
    2.9 × 109
  • b)
    4 × 108
  • c)
    7 × 109
  • d)
    3 × 109
Correct answer is option 'A'. Can you explain this answer?

Rohit Shah answered
Three billion
Haploid human genomes, which are contained in germ cells (the egg and sperm gamete cells created in the meiosis phase of sexual reproduction before fertilization creates a zygote) consist of three billion DNA base pairs, while diploid genomes (found in somatic cells) have twice the DNA content.

Which one of the following pairs of nitrogenous bases of nucleic acids, is wrongly matched with the category mentioned against it?
[2008]
  • a)
    Thymine, Uracil - Pyrimidines
  • b)
    Uracil, Cytosine - Pyrimidines
  • c)
    Guanine, Adenine - Purines
  • d)
    Adenine, Thymine - Purines 
Correct answer is option 'D'. Can you explain this answer?

Purine is an organic nitrogenous base sparingly soluble in water, that gives rise to a group of biologically important derivatives, notably adenine and guanine, which occur in nucleotides and nucleic acids (DNA and RNA). 

A man with blood group 'A' marries a woman with blood group 'B'. What are all the possible blood groups of their offsprings ?                 [2015 RS]
  • a)
    A,B and AB only
  • b)
    A,B,AB and O
  • c)
    O only
  • d)
    A and B only
Correct answer is option 'B'. Can you explain this answer?

Shruti Chauhan answered
(b) Possible × Possible genotype genotype of man with blood of woman with group A blood group B I A IA, IA IO × IB IB, IB IO If the genotype is I A IO × IB IO The possibility of resultant blood group may be A, B, AB and O.

Removal of introns and joining the exons in a defined order in a transcription unit is called:
[2009]
  • a)
    tailing
  • b)
    transformation
  • c)
    capping
  • d)
    splicing
Correct answer is option 'D'. Can you explain this answer?

Splicing is the removal of introns and joining the exons in a defined order in a transcription unit. In molecular biology, splicing is a modification of RNA after transcription, in which introns are removed and exons are joined.

In split genes, the coding sequences are called
[1995]
  • a)
    introns
  • b)
    operons
  • c)
    exons
  • d)
    cistrons
Correct answer is option 'C'. Can you explain this answer?

Rajeev Sharma answered
The region of a gene, which becomes part of m-RNA and code for different regions of the proteins are called exons.

Gene regulation governing lactose operon of E.coli that involves the lac I gene product is :             [2015 RS]
  • a)
    Negative and inducible because repressor protein prevents transcription
  • b)
    Negative and repressible because repressor protein prevents transcription
  • c)
    Feedback inhibition because excess of bgalactosidase can switch off trascription
  • d)
    Positive and inducible because it can be induced by lactose
Correct answer is option 'A'. Can you explain this answer?

Raza Great answered
In negative inducible operons, a regulatory repressor protein is normally bound to the operator, which prevents the transcription of the genes in the operon. If an inducer molecule is present, it binds to the repressor and changes its conformation so that it is unable to bind to the operator. This allows for expression of the operon. The lac operon is a negatively controlled inducible operon, where the inducer molecule is allolactose

The process of transfer of genetic information from DNA to RNA/formation of RNA from DNA is
[1991]
  • a)
    transversion
  • b)
    transcription
  • c)
    translation
  • d)
    translocation
Correct answer is option 'B'. Can you explain this answer?

Mamali . answered
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase. Both DNA and RNA are nucleic acids, which use base pairsof nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript....

Genetic code consists of
[1988]
  • a)
    cdenine and guanine
  • b)
    cytosine and uracil
  • c)
    cytosine and guanine
  • d)
    all the above
Correct answer is option 'D'. Can you explain this answer?

Kunal Rane answered
Genetic code is the relationship of amino acid sequence in a polypeptide chain and base sequence of mRNA. It includes adenine, guanine, cytosine and thymine.

At time of organogenesis genes regulate the process at different levels and at different time due to
[2001]
  • a)
    promoter
  • b)
    Exon
  • c)
    intron
  • d)
    Regulator
Correct answer is option 'B'. Can you explain this answer?

Ramesh Chand answered
In process of organogenesis, genes regulate the process at different time and levels because of Exon. An exon is the region that has useful information. Exon are the one with useful information while introns are removed from DNA by various enzymes. Therefore, option 'B' is the correct answer.

Which one of the following is the starter codon?          [2016]
  • a)
    AUG
  • b)
    UGA
  • c)
    UAA
  • d)
    UAG
Correct answer is option 'A'. Can you explain this answer?

Aman Sharma answered
(a) The start codon is the first codon of a messenger RNA (mRNA) transcript translated by a ribosome. The start codon always codes for methionine in eukaryotes and a modified Met (fMet) in prokaryotes. The most common start codon is AUG

What base is responsible for hot spots for spontaneous point mutations?
[1998]
  • a)
    Adenine
  • b)
    5-bromouracil
  • c)
    5-methylcytosine
  • d)
    Guanine
Correct answer is option 'C'. Can you explain this answer?

The term "hot spots" was used by Benzer for the sites which are more mutable than other sites. Studies in 1978 revealed that 5-methylcytosine residues occur at the position of each hot spot.

The lac operon is an example of
[1995]
  • a)
    arabinose operon
  • b)
    inducible operon
  • c)
    repressible operon
  • d)
    overlapping genes
Correct answer is option 'B'. Can you explain this answer?

Dasari Pragna answered
In the lac operon the inducer binds to the repressor RNA produced by I gene so the lac operon is in actived when the inducer binds to it so it is the example of inducible operon

In the DNA molecule
[2008]
  • a)
    the total amount of purine nucleotides and pyrimidine nucleotides is not always equal 
  • b)
    there are two strands which run parallel in the 5′ → 3′ direction
  • c)
    the proportion of Adenine in relation to thymine varies with the organism
  • d)
    there are two strands which run anti parallel one in 5′ → 3′ direction and other in 3′ → 5′
Correct answer is option 'D'. Can you explain this answer?

Subham Chavan answered
In the DNA molecule, there are two strands which run anti parallel one is 5' - 3' direction and other in 3' -5' direction, the two chains are held together by hydrogen bonds between their bases. Adenine (A), a purine of one chain his exactly opposite thymine (T), a pyramidine of the other chain. Similarly, cytosine (C), a pyrimidine lies opposite guanine (G), a purine. This allows a sort of lock & key arrangment between large sized purine & small sized pyrimidine. It is strengthened by the appearance of hydrogen bonds between the two. 

Semi-conservative replication of DNA was first demonstrated in:
[2009]
  • a)
    Escherichia coli
  • b)
    Streptococcus pneumoniae
  • c)
    Salmonella typhimurium
  • d)
    Drosophila melanogaster
Correct answer is option 'A'. Can you explain this answer?

Harshitha Dey answered
Semiconservative replication of DNA was first demonstrated in Escherichia coli. E. coli is a common type of bacteria that can get into food, like beef and vegetables. The strange thing about these bacteria is that they are not always harmful to you. E. coli normally lives inside your intestines, where it helps your body breakdown and digest the food you eat.

A DNA with unequal nitrogen bases would most probably be
[1993]
  • a)
    single stranded
  • b)
    double stranded
  • c)
    triple stranded
  • d)
    four stranded
Correct answer is option 'A'. Can you explain this answer?

Anjali Iyer answered
A DNA with unequal nitrogen bases would most probably be single stranded because unequal nitrogen bases can not make bonds to form double strand.

In transgenics, expression of transgene in target tissue is determined by
[2004]
  • a)
    enhancer
  • b)
    promoter
  • c)
     reporter
  • d)
    transgene
Correct answer is option 'B'. Can you explain this answer?

Raza Great answered
In a transgenic organism, reporter genes are used to determine whether a particular DNA construct has been successfully introduced into a cell, organ or tissue. Whereas promoter is the region of DNA that initiates the DNA transcription, an enhancer is the sequence of DNA that enhances the transcription when binds to the specific proteic and transgene is the gene that taken from the genome of one organism and introduces into the genome of another organism.

A mutation at one base of the first codon, of a gene, produces a non-functional protein. Such a mutation is called
[1997]
  • a)
    nonsense mutation
  • b)
    missense mutation
  • c)
    frameshift mutation
  • d)
    reverse mutation
Correct answer is option 'B'. Can you explain this answer?

Rohan Singh answered
A mutation at one base of the first codon of a gene produces a non-functional protein. Such a mutation is known as missense mutation. Hence,option (b) is correct.

Hope this information will clear your doubts about the topic.   

Satellite DNA is useful tool in:
[2010]
  • a)
    organ transplantation
  • b)
    sex determination
  • c)
    forensic science
  • d)
    genetic engineering
Correct answer is option 'C'. Can you explain this answer?

Satellite DNA is useful in forensic science. The polymorphism of minisatellite, microsatellite and minivariant repeats is analysed for DNA finger printing, DNA profiling. It helps in the resolution of crimes, legal disputes etc.

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