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All questions of Cell Cycle and Cell Division for NEET Exam

When does synapsis occur during meiosis
a)Leptotene
b)Zygotene
c)Diplotene
D)Pachytene 
Correct answer is option 'B'. Can you explain this answer?

Gaurav Kumar answered
In meiosis I, synapsis formation occurs in the zygotene stage of prophase-I. It is the second stage of prophase-I. During this stage, the chromosomes start pairing together and this process of association called synapsis. Such paired chromosomes are called homologous chromosomes. This synapsis is accompanied by the formation of synaptonemal complex formed by bivalent or tetrad chromosomes. 

In cell cycle, DNA replication takes place in
[1996, 2000]
  • a)
    G1 phase
  • b)
    G2 phase
  • c)
    mitotic metaphase
  • d)
    S phase
Correct answer is option 'D'. Can you explain this answer?

Arya Khanna answered
G1 phase, also called Gap I phase is characterized by increase in cell size. In the S phase or synthetic phase DNA molecules replicate. G2 is the second growth phase. Gap II where in there is intensive formation of RNAs and  proteins. In the mitotic metaphase, the chromosomes are arranged at the equatorial plate.

Which one of the following structures will not be common to mitotic cells of higher plants?
[1997]
  • a)
    cell plate
  • b)
    centriole
  • c)
    centromere
  • d)
    spindle fibres
Correct answer is option 'B'. Can you explain this answer?

Arya Khanna answered
Plants cells do not have centrioles. Cell plate appears during cytokinesis in dividing cells. Centromere holds the sister chromatids in a chromosome. Spindle fibres appear during metaphase.

Meiosis I is reductional division. Meiosis II is equational division due to
  • a)
    pairing of homologous chromosomes
  • b)
    crossing over
  • c)
    separation of chromatids
  • d)
    disjunction of homologous chromo
Correct answer is option 'C'. Can you explain this answer?

Aditi Singh answered
Explanation:

Meiosis I is the first stage of meiosis, where the homologous chromosomes pair up and exchange genetic material through crossing over. This stage is known as reductional division because it reduces the number of chromosomes in the cell by half. Meiosis II, on the other hand, is equational division because it divides the sister chromatids into two separate cells, resulting in four haploid cells with the same number of chromosomes as the parent cell.

The correct answer is option C, separation of chromatids. During meiosis II, the sister chromatids separate from each other and move towards opposite poles of the cell. This is referred to as chromatid disjunction and results in the formation of four haploid cells.

Option A, pairing of homologous chromosomes, is a characteristic of meiosis I, where homologous chromosomes pair up to form bivalents.

Option B, crossing over, also occurs during meiosis I, where homologous chromosomes exchange genetic material.

Option D, disjunction of homologous chromosomes, occurs during meiosis I, where homologous chromosomes separate from each other and move towards opposite poles of the cell.

Best stage to observe shape, size and number of chromosomes is
[1994]
  • a)
    interphase
  • b)
    metaphase
  • c)
    prophase
  • d)
    telophase
Correct answer is option 'B'. Can you explain this answer?

Swara Desai answered
During metaphase, the centomeres of the chromosome lie on the equatorial plate according to their size and spatial arrangement. So it is the best time to count the number and study the morphology of chromosomes.

How many mitotic divisions are needed for a single cell to make 128 cells? [1997]
a) 7
b) 14
c) 28
d) 64
Correct answer is option 'A'. Can you explain this answer?

Rajeev Saxena answered
Here's your answer !!!

7 mitotic divisions ...

During mitotic divisions : 
▶1 cell ➡ 2cells (1st mitosis) 

▶2cells ➡4cells (2nd mitosis )

▶4 cells ➡ 8cells (3rd mitosis ) 

▶8 cells ➡ 16 cells (4th mitosis) 

▶16 cells ➡ 32 cells (5th mitosis)

▶32 cells ➡64 cells (6th mitosis )

▶64 cells ➡ 128 cells (7th mitosis ) 

Hence , 7 mitotic divisions are needed to form 128 cells from 1 cell in plants.

Which of the following statements is not true for cancer cells in relation to mutations ?     [2016]
  • a)
    Mutations in proto-oncogenes accelerate the cell cycle.
  • b)
    Mutations destroy telomerase inhibitor.
  • c)
    Mutations inactive the cell control.
  • d)
    Mutations inhibit production of telomerase. 
Correct answer is option 'D'. Can you explain this answer?

The ability to maintain functional telomeres may be one mechanism that allows cancer cells to grow in vitro for decades. Telomerase activity is necessary to preserve many cancer types and is inactive in somatic cells, creating the possibility that telomerase inhibition could selectively repress cancer cell growth with minimal side effects. Mutation can inhibit telomerase in cancer cells, the telomeres of successive generations will progressively shorten, limiting tumor growth.
So the correct option is 'Mutations inhibit the production of telomerase'.

If a diploid cell is treated with colchicine then it becomes
[2002]
  • a)
    triploid
  • b)
    tetraploid
  • c)
    diploid
  • d)
    monoploid
Correct answer is option 'B'. Can you explain this answer?

Charvi Shah answered
Colchicine inhibits spindle formation, due to which chromatids are unable to separate during anaphase which results in doubling of chromosomes. So, if a diploid cell is treated with colchicine, there is doubling of chromosomes and it becomes tetraploid,. Its an alkaloid obtained from Colchicum autumnale.

Segregation of mendelian factor (Aa) occurs during
[1990]
  • a)
    Diplotene
  • b)
    Anaphase I
  • c)
    Zygotene/Pachytene
  • d)
    Anaphase II
Correct answer is option 'B'. Can you explain this answer?

Ritika Reddy answered
The correct answer is option B, Anaphase I.

Explanation:
Mendelian factors or genes segregate during the process of meiosis. Meiosis is a type of cell division that occurs in the reproductive cells of sexually reproducing organisms. During meiosis, the chromosome number is reduced by half, from diploid (2n) to haploid (n).

The segregation of Mendelian factors occurs during the first division of meiosis, which is called meiosis I. Meiosis I consists of four stages: prophase I, metaphase I, anaphase I, and telophase I.

During prophase I, the homologous chromosomes pair up and exchange segments of DNA through a process called crossing over. This results in the formation of new combinations of genes on the chromosomes.

During metaphase I, the homologous chromosomes line up at the equator of the cell.

During anaphase I, the homologous chromosomes separate and move towards opposite poles of the cell. This is the stage where the segregation of Mendelian factors occurs. Each chromosome contains two copies of each gene, one from each parent. During anaphase I, the homologous chromosomes separate and each daughter cell receives only one copy of each gene.

During telophase I, the chromosomes reach the opposite poles of the cell and the cell divides into two daughter cells. Each daughter cell contains half the number of chromosomes as the original cell.

In conclusion, the segregation of Mendelian factors occurs during anaphase I of meiosis.

A somatic cell that has just completed the S phase of its cell cycle, as compared to gamete of the same species, has :    [2015 RS]
  • a)
    twice the number of chromosomes and four times the amount of DNA
  • b)
    same number of chromosomes but twice the amount of DNA
  • c)
    four times the number of chromosomes and twice the amount of DNA
  • d)
    twice the number of chromosomes and twice the amount of DNA
Correct answer is option 'B'. Can you explain this answer?

Arindam Khanna answered
The correct option is Option B.
A somatic cell that has just completed the S phase of its cell cycle has replicated its DNA but has not yet undergone cell division (mitosis). Therefore, it has the same number of chromosomes as before S phase but twice the amount of DNA, because each chromosome has been replicated into two sister chromatids.

A cell plate is laid down during
  • a)
    Cytokinesis
  • b)
    Interphase
  • c)
    Karyokinesis
  • d)
    None of these
Correct answer is option 'A'. Can you explain this answer?

Ramesh Chand answered
Cytokinesis in terrestrial plants occurs by cell plate formation. This process entails the delivery of Golgi derived and endosomal vesicles carrying cell wall and cell membrane components to the plane of cell division and the subsequent fusion of these vesicles within this plate.

In meiosis crossing over is initiated at                [2016]
  • a)
    Pachytene
  • b)
    Leptotene
  • c)
    Zygotene
  • d)
    Diplotene
Correct answer is option 'A'. Can you explain this answer?

(a) Meiosis is a process (discovered by German biologist, Oscar Hertwig) where a single cell divides twice to produce four cells containing half the original amount of genetic information. These cells are our sex cells - sperm in males, eggs in females. Crossing over is the process by which two chromosomes, exchange some distal part of their DNA. This process occurs in the Pachytene stage of Prophase I of meiosis.

At what stage of the cell cycle are histone proteins synthesized in a eukaryotic cell?
[2005]
  • a)
    During G­-2 stage of prophase
  • b)
    During S-­phase
  • c)
    During entire prophase
  • d)
    During telophase
Correct answer is option 'B'. Can you explain this answer?

Swara Desai answered
Histone proteins are synthesized during S­phase of cell cycle. S­phase or Synthetic phase.
 Histone proteins are basic proteins and are used in packing of eukaryotic (absent in prokaryotes) DNA. DNA and histones together comprise chromatin, forming bulk of the eukaryotic chromosomes. Histones are of five major kinds 
H1,H2A,H2B,H3
 and 
H4H1
 histones link neighbouring nucleosomes (fundamental packing units of an eukaryotic chromosome), while other are elements of nucleosome structure. During S-phase of cell cycle synthesis of histone proteins take place because at this stage number of chromosomes become double to that of somatic number

Meiosis is evolutionary significant because it result in
[1994]
  • a)
    genetically similar daughters
  • b)
    four daughter cells
  • c)
    eggs and sperms
  • d)
    recombinations
Correct answer is option 'D'. Can you explain this answer?

Arya Khanna answered
Meiosis provides a chance for new combinations of chromosomes mainly by the phenomenon of crossing over and random distribution of homologous chromosomes between daughter cells.

Lampbrush chromosomes occur during
[1996]
  • a)
    prophase of mitosis
  • b)
    diplotene of meiosis
  • c)
    metaphase of meiosis
  • d)
    interphase
Correct answer is option 'B'. Can you explain this answer?

Prisha Singh answered
Lampbrush chromosomes are highly elongated bivalent chromosomes of diplotene stage, which are held together by chiasmata and  have a large number of lateral loops for rapid transcription.

During cell division in apical meristem the nuclear membrane appears in
[1997]
  • a)
    metaphase
  • b)
    anaphase
  • c)
    telophase
  • d)
    cytokinesis
Correct answer is option 'C'. Can you explain this answer?

Priyanka Iyer answered
Metaphase in characterized by the appearance of spindle fibres. Anaphase involves movement of chromatids towards the poles. Cytokinesis marks the division of the cytoplasm of the parent cell into daughter cells.
The nuclear membrane is present at prophase, when the cell moves from prophase it disappers and again it reappears in telophase.

The exchange of genetic material between chromatids of paired homologous chromosomes during first meiotic division is called
[1996]
  • a)
    transformation
  • b)
    chiasmata
  • c)
    crossing over
  • d)
    synapsis 
Correct answer is option 'C'. Can you explain this answer?

Swara Desai answered
The points of attachment between homologous chromosomes after their separation in diplotene are called  chiasmata. The process of pairing of homologous chromosomes is called synapsis the phenomenon by which DNA isolated from one type of cell, when introduced into another type, is able to bestow some of the properties of the former to the latter is known as transformation.

The stage during which separation of the paired homologous chromosomes begins is   [2018]
  • a)
    Pachytene
  • b)
    Diplotene
  • c)
    Diakinesis
  • d)
    Zygotene
Correct answer is option 'B'. Can you explain this answer?

Ashish Ghosh answered
Diplotene
The correct stage during which separation of the paired homologous chromosomes begins is the diplotene stage. This stage is a sub-phase of meiosis, specifically occurring during the first meiotic division.

Explanation:

1. Diplotene Stage:
- The diplotene stage is characterized by the separation of the paired homologous chromosomes, which were initially paired during the preceding prophase I stages (leptotene, zygotene, and pachytene).
- During diplotene, the homologous chromosomes begin to move apart but are still connected at points called chiasmata, where genetic recombination has occurred.
- This stage allows for the exchange of genetic material between homologous chromosomes, leading to genetic diversity in the resulting gametes.

Comparison with Other Prophase I Stages:
- Leptotene: The chromosomes start to condense.
- Zygotene: Homologous chromosomes begin to pair up.
- Pachytene: Pairing of homologous chromosomes is complete, and crossing over occurs.
- Diakinesis: Chromosomes condense further, and the nuclear envelope breaks down.

Significance:
- The separation of homologous chromosomes during diplotene is crucial for ensuring that each resulting gamete receives a unique combination of genetic material.
- This genetic diversity is essential for evolution and adaptation in sexually reproducing organisms.
In conclusion, the diplotene stage of meiosis is where the separation of paired homologous chromosomes begins, setting the stage for the subsequent events in meiotic division.

Which of the following is not a characteristic feature during mitosis in somatic cells ?       [2016]
  • a)
    Spindle fibres
  • b)
    Disappearance of nucleolus
  • c)
    Chromosome movement
  • d)
    Synapsis 
Correct answer is option 'D'. Can you explain this answer?

Muskaan Basak answered
(d) Synapsis is the pairing of two homologous chromosomes that occurs during meiosis. It allows matching-up of homologous pairs prior to their segregation, and possible chromosomal crossover between them. Synapsis takes place during prophase I, Zygotene of meiosis. 

Which of the following stages of meiosis involves division of centromere? [2021]
  • a)
    Anaphase II
  • b)
    Telophase II
  • c)
    Metaphase I
  • d)
    Metaphase II
Correct answer is option 'A'. Can you explain this answer?

Gaurav Kumar answered
Anaphase II: It begins with the simultaneous splitting of the centromere of each chromosome (which was holding the sister chromatids together), allowing them to move toward opposite poles of the cell by shortening of microtubules attached to kinetochores.

Cells in GO phase    [2019]
  • a)
    Foramtion of new cell
  • b)
    Exit the cell cycle
  • c)
    Enter the cell cycle
  • d)
    None of these
Correct answer is option 'B'. Can you explain this answer?

Suresh Iyer answered
Cells in the G0 phase have exited the cell cycle and are not actively dividing. However, they are still metabolically active and capable of responding to stimuli that can cause them to reenter the cell cycle and divide. The G0 phase is also referred to as the "quiescent phase," as the cells are in a state of relative rest or quiescence. Cells in the G0 phase may be found in tissues that do not require frequent cell division, such as fully developed organs, or in cells that have undergone cellular senescence and are no longer able to divide. The G0 phase is a normal part of the cell cycle and is not necessarily a terminal phase; cells can return to the G1 phase and reenter the cell cycle if the appropriate signals are received.

Which of the following options gives the correct sequence of events during mitosis?    [2017]
  • a)
    Condensation → Nuclear membrane disassembly → Arrangement at equator → Centromere division → Segregation → Telophase
  • b)
    Condensation → Crossing over → Nuclear membrane disassembly → Segregation → Telophase
  • c)
    Condensation → Arrangement at equator → Centromere division → Segregation → Telophase
  • d)
    Condensation → Nuclear membrane disassembly → Crossing over → Segregation → Telophase
Correct answer is option 'A'. Can you explain this answer?

Ananya Das answered
Mitosis is divided into four phase prophase, metaphase, anaphase and telophase. During prophase, the indistinct and intertwined DNA molecule condenses to form elongated chromosomes. The nuclear membrane disintegrates during prometaphase During metaphase, the chromosomes align themselves at the equatorial plate. During anaphase, centromere of each chromosome divides into two so that each chromosome come to have its own centromere Chromatids move towards opposite poles along the path of their chromosome fibres. Finally, during telophase, two chromosome groups reorganise to form two nuclei. Nuclear envelope reappears, Golgi complex and endoplasmic reticulum are reformed Crossing over occurs during meiosis.
Option (c) also gives the correct sequence of event but it misses step II (nuclear membrane disassembly). Hence, is ruled out as best appropriate answer is option (a).

In the somatic cell cycle
[2004]
  • a)
    In G1 phase DNA content is double the amount of DNA present in the original cell 
  • b)
    DNA replication takes place in S­phase
  • c)
    a short interphase is followed by a long mitotic phase
  • d)
    G2 phase follows mitotic phase
Correct answer is option 'B'. Can you explain this answer?

Dipanjan Mehta answered
DNA replication is restricted to S­ phase of interphase.  G2 phase is followed by the mitotic phase which is shorter than the inter phase.  In G2  phase DNA content is double than the amount present in the original cell.

If you are provided with root­tips of onion in your class and are asked to count the chromosomes, which of the following stages can you most conveniently look into?
[2004]
  • a)
    Metaphase
  • b)
    Telophase
  • c)
    Anaphase
  • d)
    Prophase
Correct answer is option 'A'. Can you explain this answer?

Arya Khanna answered
Chromosomes are most distinct  in the metaphase stage. In the telophase stage they  regain their  coiled composition. In anaphase the chromatids separate and move towards opposite poles. In prophase stage the chromosomes appear thread like and individual chromatids cannot be seen.

Spindle fibres attach on to          [2016]
  • a)
    Telomere of the chromosome
  • b)
    Kinetochore of the chromosome
  • c)
    Centromere of the chromosome
  • d)
    Kinetosome of the chromosome
Correct answer is option 'B'. Can you explain this answer?

Harshitha Dey answered
(b) Attachment of microtubules to chromosomes is mediated by kinetochores, which actively monitor spindle formation and prevent premature anaphase onset during mitosis. 

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