Colchicine is employed to diploidize a haploid cell as it[1996]a)inhibits mitosisb)inhibits formation of mitotic spindlec)allows replication of DNA twice in one cell cycled)inhibits formation of centromereCorrect answer is option 'B'. Can you explain this answer?

Question

Answer

Option B is correct, colchicin is also called as mitotic poison it inhibits the spindle fibers formation during meta phase..

Answer

C as

Answer

Colchicines prevent spindle formation during mitotic metaphase. Thus, it prevents the separation of chromosomes during anaphase stage. So, option b is correct.

Answer

Explanation:

Introduction to Colchicine:
Colchicine is a medication that is commonly used to treat gout and familial Mediterranean fever. It is derived from the autumn crocus plant, also known as Colchicum autumnale. Colchicine works by inhibiting the polymerization of tubulin, a protein involved in the formation of microtubules.

Colchicine and Diploidization:
Diploidization is the process of converting a haploid cell, which contains a single set of chromosomes, into a diploid cell, which contains two sets of chromosomes. Colchicine is employed in this process because it inhibits the formation of the mitotic spindle.

Mitotic Spindle:
The mitotic spindle is a structure composed of microtubules that forms during cell division and is responsible for separating the chromosomes into two daughter cells. It helps in the equal distribution of genetic material.

Inhibition of Mitotic Spindle Formation:
Colchicine inhibits the formation of the mitotic spindle by preventing the polymerization of tubulin, which is necessary for the assembly of the microtubules that make up the spindle. Without a functional mitotic spindle, the chromosomes cannot properly align and separate during cell division.

Effect on Haploid Cell:
When a haploid cell is treated with colchicine, it is unable to undergo mitosis and divide into two daughter cells. This leads to a situation where the cell undergoes DNA replication but fails to divide, resulting in a cell with twice the amount of DNA. This cell is now diploid as it contains two sets of chromosomes.

Importance of Diploidization:
Diploidization is an important process in certain areas of research, such as plant breeding and genetic engineering. It allows for the production of plants with desirable traits by generating a cell with twice the amount of genetic material. This cell can then be used as a starting point for further breeding or genetic manipulation.

Conclusion:
In summary, colchicine is employed to diploidize a haploid cell by inhibiting the formation of the mitotic spindle. This prevents the cell from undergoing mitosis and division, resulting in a cell with twice the amount of DNA and becoming diploid. Diploidization is an important process in certain areas of research and colchicine is a useful tool in achieving this.

Answer

Colchicine acts as a poision.. it inhibits the polymerisation of mitotic spindles, arrests the division at metaphase stage

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