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The main product formed by treating an alkyl or benzyl halide with excess ammonia
  • a)
    Mixed
  • b)
    Tertiary
  • c)
    Secondary
  • d)
    Primary
Correct answer is option 'D'. Can you explain this answer?

Amita Das answered
The N in ammonia functions as the nucleophile and attacks the electrophilic C of the alkyl halide displacing the bromide and creating the new C-N bond. 
Step 2: An acid/base reaction. The base (excess ammonia) deprotonates the positive N (ammonium) center creating the alkylation product, the primary amine.

The Hofmann elimination proceeds via a(n) __________ pathway.
  • a)
    SN2
  • b)
    E2
  • c)
    E1
  • d)
    SN1
Correct answer is option 'B'. Can you explain this answer?

Rajat Kapoor answered
The Hofmann Elimination is an elimination reaction that forms C-C double (pi) bonds that specifically occurs when the leaving group is NR3 [note] It proceeds through an E2 mechanism. Although the key concepts are no different than one learns in the chapter on elimination from way back in Org 1, it is often included in Org 2 as part of the grab-bag chapter on amines. Because, well… nitrogen.

Which one of the following is used to increase blood pressure
  • a)
    Ephedrine
  • b)
    Novocain
  • c)
    Benadryl
  • d)
    None of these
Correct answer is option 'A'. Can you explain this answer?

Anjali Iyer answered
Correct answer is d) none of these:

1. Fludrocortisone is a medication that seems to help most types of low blood pressure. It works by promoting sodium retention by the kidney, thereby causing fluid retention and some swelling, which is necessary to improve blood pressure. 
2. Midodrine activates receptors on the smallest arteries and veins to produce an increase in blood pressure. It is used to help increase standing blood pressure in people with postural hypotension related to nervous system dysfunction.

Diazonium salts are used in the preparation of
  • a)
    Hormones
  • b)
    Vitamins
  • c)
    Dyes
  • d)
    Proteins
Correct answer is option 'C'. Can you explain this answer?

Vijay Bansal answered
A diazonium salt is an organic compound that contains a nitrogen-nitrogen triple bond and some other generic side group that could be either alkyl (an alkane derivative) or aryl (benzene ring). The 'salt' portion of the name comes from the fact that the diazo (meaning 'di-nitrogen') portion of the compound is present as its ionic salt, with a chloride ion being a typical counter-ion for the positively charged nitrogen atom.

Which of the following is a tertiary amine?
  • a)
    Diphenhydramine
  • b)
    Adrenaline
  • c)
    Ephedrine
  • d)
    Novocaine
Correct answer is option 'A'. Can you explain this answer?

Diphenhydramine​ is an antihistamine mainly used to treat allergies. It can also be used for insomnia, symptoms of the common cold, tremor in parkinsonism, and nausea. It is used by mouth, injection into a vein, injection into a muscle, or applied to the skin.

The general formula of a primary amine is:
  • a)
    R-NH2
  • b)
    R-NH-R
  • c)
    R-NH-R1-R2
  • d)
    R-NH3+
Correct answer is option 'A'. Can you explain this answer?

Deepak Iyer answered
The general formula of a primary amine is R-NH2, where R represents an alkyl or aryl group. This formula indicates that the nitrogen atom is bonded to one alkyl or aryl group and one hydrogen atom.

Which of the following statements about amines is true?
  • a)
    Amines can only be synthesized from ammonia.
  • b)
    Amines have a higher boiling point than their corresponding alcohols.
  • c)
    Amines cannot form hydrogen bonds.
  • d)
    Amines are always liquids at room temperature.
Correct answer is option 'B'. Can you explain this answer?

Deepak Iyer answered
Amines have higher boiling points than their corresponding alcohols of similar molecular weight. This is due to the presence of intermolecular hydrogen bonding in amines, whereas alcohols can form both intermolecular and intramolecular hydrogen bonds.

How many hydrogen atoms are directly bonded to the nitrogen atom in a tertiary amine?
  • a)
    0
  • b)
    1
  • c)
    2
  • d)
    3
Correct answer is option 'A'. Can you explain this answer?

Deepak Iyer answered
In a tertiary amine, the nitrogen atom is bonded to three alkyl or aryl groups and does not have any hydrogen atoms directly attached to it. Tertiary amines have the general formula R3N.

Which of the following compounds is a tertiary amine?
  • a)
    CH3NH2
  • b)
    CH3NHCH3
  • c)
    (CH3)3N
  • d)
    (CH3)2NH
Correct answer is option 'C'. Can you explain this answer?

Deepak Iyer answered
(CH3)3N is a tertiary amine because it has three methyl groups attached to the nitrogen atom. It does not have any hydrogen atoms directly bonded to the nitrogen.

Amines are derivatives of which of the following functional groups?
  • a)
    Alcohols
  • b)
    Aldehydes
  • c)
    Carboxylic acids
  • d)
    Ammonia
Correct answer is option 'D'. Can you explain this answer?

Deepak Iyer answered
Amines are derivatives of ammonia (NH3) in which one or more of the hydrogen atoms are replaced by alkyl or aryl groups. They are formed by replacing one or more hydrogen atoms in ammonia with alkyl or aryl groups.

Which of the following is a secondary amine?
  • a)
    Methylamine
  • b)
    Diethylamine
  • c)
    Trimethylamine
  • d)
    Ethylamine
Correct answer is option 'B'. Can you explain this answer?

Deepak Iyer answered
Diethylamine is a secondary amine because it has two alkyl groups (ethyl groups) attached to the nitrogen atom. In secondary amines, the nitrogen atom is bonded to two alkyl groups and one hydrogen atom.

The process of converting a primary amine to a secondary amine is called:
  • a)
    Substitution
  • b)
    Dehydration
  • c)
    Dehydrogenation
  • d)
    N-alkylation
Correct answer is option 'D'. Can you explain this answer?

Deepak Iyer answered
The process of converting a primary amine to a secondary amine is called N-alkylation. It involves the substitution of an alkyl group for one of the hydrogen atoms bonded to the nitrogen atom.

Which of the following is an example of a primary amine?
  • a)
    Dimethylamine
  • b)
    Diethylamine
  • c)
    Ethylamine
  • d)
    Trimethylamine
Correct answer is option 'C'. Can you explain this answer?

Deepak Iyer answered
Ethylamine is a primary amine because it has only one alkyl group (ethyl group) attached to the nitrogen atom. In primary amines, the nitrogen atom is bonded to one alkyl group and two hydrogen atoms.

Which of the following reagents can be used to distinguish between primary, secondary, and tertiary amines?
  • a)
    Sodium hydroxide
  • b)
    Hydrochloric acid
  • c)
    Sodium nitrite
  • d)
    Hinsberg reagent
Correct answer is option 'D'. Can you explain this answer?

Deepak Iyer answered
Hinsberg reagent (benzenesulfonyl chloride) can be used to distinguish between primary, secondary, and tertiary amines. It reacts differently with each type of amine, forming distinct products that can be identified. Primary amines give N-alkylbenzenesulfonamide, secondary amines give N,N-dialkylbenzenesulfonamide, and tertiary amines do not react with Hinsberg reagent.

Which of the following amines is a strong base?
  • a)
    Aniline
  • b)
    Ethylamine
  • c)
    Dimethylamine
  • d)
    Pyrrole
Correct answer is option 'B'. Can you explain this answer?

Deepak Iyer answered
Ethylamine is a strong base because it readily accepts a proton (H+) to form the ethylammonium ion (C2H5NH3+). It has a lone pair of electrons on the nitrogen atom, which can easily accept a proton.

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