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Sickle cell anaemia is induced by [2001]
- a)change of amino acid in a-chain of haemoglobin
- b)change of amino acid in b-chain of haemoglobin
- c)change of amino acid in both a- and b-chain of haemoglobin
- d)change of amino acid in either a- or b-chain of haemoglobin
Correct answer is option 'B'. Can you explain this answer?
Verified Answer
Sickle cell anaemia is induced by [2001]a)change of amino acid in a-ch...
Sickle cell anaemia is a hereditary disorder of autosomal nature caused by mutation of the gene controlling b-chain of haemoglobin. It involves substitution of glutamine by valine.
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Sickle cell anaemia is induced by [2001]a)change of amino acid in a-ch...
Sickle Cell Anaemia Overview
Sickle cell anaemia is a genetic disorder caused by a mutation in the hemoglobin gene, which leads to the production of abnormal hemoglobin known as hemoglobin S (HbS).
Key Mutation Details
- The mutation occurs specifically in the β-chain of hemoglobin.
- In sickle cell anaemia, the amino acid at the sixth position of the β-globin chain is altered from glutamic acid to valine.
Impact of the Mutation
- This single amino acid change drastically alters the physical properties of hemoglobin.
- HbS molecules tend to aggregate under low oxygen conditions, leading to the characteristic sickle shape of red blood cells.
- These sickle-shaped cells are less flexible and can obstruct blood flow, causing pain and various complications.
Comparison with Other Chains
- The α-chain of hemoglobin remains unchanged in sickle cell anaemia.
- Therefore, while mutations can affect both the α- and β-chains in other disorders, sickle cell anaemia specifically involves only the β-chain mutation.
Conclusion
- The correct answer to the question is option 'B': change of amino acid in the β-chain of hemoglobin. This pinpoint mutation is crucial for understanding the pathology of sickle cell anaemia and its clinical manifestations.
Sickle cell anaemia is a genetic disorder caused by a mutation in the hemoglobin gene, which leads to the production of abnormal hemoglobin known as hemoglobin S (HbS).
Key Mutation Details
- The mutation occurs specifically in the β-chain of hemoglobin.
- In sickle cell anaemia, the amino acid at the sixth position of the β-globin chain is altered from glutamic acid to valine.
Impact of the Mutation
- This single amino acid change drastically alters the physical properties of hemoglobin.
- HbS molecules tend to aggregate under low oxygen conditions, leading to the characteristic sickle shape of red blood cells.
- These sickle-shaped cells are less flexible and can obstruct blood flow, causing pain and various complications.
Comparison with Other Chains
- The α-chain of hemoglobin remains unchanged in sickle cell anaemia.
- Therefore, while mutations can affect both the α- and β-chains in other disorders, sickle cell anaemia specifically involves only the β-chain mutation.
Conclusion
- The correct answer to the question is option 'B': change of amino acid in the β-chain of hemoglobin. This pinpoint mutation is crucial for understanding the pathology of sickle cell anaemia and its clinical manifestations.
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Sickle cell anaemia is induced by [2001]a)change of amino acid in a-chain of haemoglobinb)change of amino acid in b-chain of haemoglobinc)change of amino acid in both a- and b-chain of haemoglobind)change of amino acid in either a- or b-chain of haemoglobinCorrect answer is option 'B'. Can you explain this answer? for NEET 2025 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about Sickle cell anaemia is induced by [2001]a)change of amino acid in a-chain of haemoglobinb)change of amino acid in b-chain of haemoglobinc)change of amino acid in both a- and b-chain of haemoglobind)change of amino acid in either a- or b-chain of haemoglobinCorrect answer is option 'B'. Can you explain this answer? covers all topics & solutions for NEET 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Sickle cell anaemia is induced by [2001]a)change of amino acid in a-chain of haemoglobinb)change of amino acid in b-chain of haemoglobinc)change of amino acid in both a- and b-chain of haemoglobind)change of amino acid in either a- or b-chain of haemoglobinCorrect answer is option 'B'. Can you explain this answer?.
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Sickle cell anaemia is induced by [2001]a)change of amino acid in a-chain of haemoglobinb)change of amino acid in b-chain of haemoglobinc)change of amino acid in both a- and b-chain of haemoglobind)change of amino acid in either a- or b-chain of haemoglobinCorrect answer is option 'B'. Can you explain this answer?, a detailed solution for Sickle cell anaemia is induced by [2001]a)change of amino acid in a-chain of haemoglobinb)change of amino acid in b-chain of haemoglobinc)change of amino acid in both a- and b-chain of haemoglobind)change of amino acid in either a- or b-chain of haemoglobinCorrect answer is option 'B'. Can you explain this answer? has been provided alongside types of Sickle cell anaemia is induced by [2001]a)change of amino acid in a-chain of haemoglobinb)change of amino acid in b-chain of haemoglobinc)change of amino acid in both a- and b-chain of haemoglobind)change of amino acid in either a- or b-chain of haemoglobinCorrect answer is option 'B'. Can you explain this answer? theory, EduRev gives you an
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