Basement membrane is made up of[1997]a)epidermal cells onlyb)endoderma...
Basement membrane is a delicate noncellular layer made of extracellular material that lies below the epithelium in contact with its basal surface. Basement membrane is a delicate noncellular layer made of extracellular material that lies below the epithelium in contact with its basal surface. Besides this the basal lamina consists of mucopoly saccharides and very fine fibres.
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Basement membrane is made up of[1997]a)epidermal cells onlyb)endoderma...
Basement membrane is made up of[1997]a)epidermal cells onlyb)endoderma...
Basement membrane is a specialized extracellular matrix that forms a thin layer of tissue between the epithelial cells and the underlying connective tissue. It plays an important role in providing structural support, regulating cell behavior, and maintaining tissue integrity.
Composition of Basement Membrane:
The basement membrane is made up of several components, including:
1. Collagen: It is the most abundant protein in the basement membrane and provides tensile strength and stability to the tissue.
2. Proteoglycans: They are large molecules made up of a protein core and long chains of sugar molecules. They provide the basement membrane with compressive strength and help regulate the movement of molecules through the tissue.
3. Laminins: They are glycoproteins that form a network of cross-linked fibers in the basement membrane. They play a key role in cell adhesion and signaling.
4. Nidogens: They are glycoproteins that cross-link laminins and other basement membrane components, helping to stabilize the tissue.
5. Enzymes and growth factors: They are present in the basement membrane and help regulate cell behavior and tissue repair.
Origin of Basement Membrane:
The basement membrane is produced by epithelial cells and is found in close association with these cells. It is also present in other tissues, such as muscle and nerve, where it is produced by specialized cells called Schwann cells and myofibroblasts.
Functions of Basement Membrane:
1. Structural support: The basement membrane provides a stable, supportive foundation for epithelial cells and helps maintain tissue integrity.
2. Cell adhesion and migration: The basement membrane contains proteins that promote cell adhesion and migration, allowing cells to move through the tissue during development, wound healing, and other processes.
3. Barrier function: The basement membrane forms a barrier between the epithelial cells and the underlying connective tissue, helping to regulate the movement of molecules and cells between these two compartments.
4. Signaling: The basement membrane contains growth factors and other signaling molecules that regulate cell behavior and tissue development.
Conclusion:
In conclusion, the basement membrane is a complex extracellular matrix that plays a critical role in tissue function and maintenance. It is composed of several components, including collagen, proteoglycans, laminins, nidogens, enzymes, and growth factors, and is produced by epithelial cells and other specialized cells. Its functions include structural support, cell adhesion and migration, barrier function, and signaling.
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