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The process of migration of chloride ions from plasma to RBC and of carbonate ions from RBC to plasma is [1999]
  • a)
    chloride shift
  • b)
    ionic shift
  • c)
    atomic shift
  • d)
    Na+ pump
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
The process of migration of chloride ions from plasma to RBC and of ca...
During the transport of CO2 through the blood, bicarbonate ions diffuse out of RBCs while chloride ions from plasma enter the RBCs to maintain ionic equilibrium. This is called chloride shift.
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The process of migration of chloride ions from plasma to RBC and of ca...
The Chloride Shift Explained
The chloride shift is a crucial physiological process that facilitates gas exchange in the bloodstream, particularly in the context of carbon dioxide transport.
Key Processes Involved:
- Chloride Ion Migration: As carbon dioxide (CO2) diffuses into red blood cells (RBCs) from tissues, it reacts with water to form carbonic acid, which dissociates into bicarbonate ions (HCO3-) and hydrogen ions (H+).
- Bicarbonate Ion Transport: The bicarbonate ions produced inside the RBCs are transported out into the plasma. This is essential for maintaining the acid-base balance in the blood.
- Chloride Ion Influx: To maintain electrical neutrality, chloride ions (Cl-) from the plasma move into the RBCs as bicarbonate ions exit. This exchange of ions is what constitutes the chloride shift.
Physiological Importance:
- Maintaining pH Balance: The movement of bicarbonate and chloride helps regulate the pH level of the blood, preventing acidosis or alkalosis.
- Facilitating Gas Exchange: By promoting the transport of CO2 in the form of bicarbonate, the chloride shift plays a vital role in efficient gas exchange in the lungs.
- Enhancing Oxygen Delivery: The shift helps in optimizing the conditions for oxygen binding to hemoglobin in red blood cells, thereby improving oxygen delivery to tissues.
Conclusion:
In summary, the chloride shift is a critical mechanism that involves the movement of chloride ions from plasma into red blood cells and bicarbonate ions from red blood cells into plasma. This process not only aids in transporting CO2 but also plays a significant role in maintaining acid-base balance and enhancing oxygen delivery, making option 'A' the correct answer.
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