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Which of the following statements is incorrect for sickle cell anaemia?
- a)Sixth amino acid (from NH2 terminus) of beta chain is glutamic acid.
- b)Erythrocytes elongate and form sickle-shaped cells.
- c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.
- d)Beta chain of haemoglobin S contains valine.
Correct answer is option 'A'. Can you explain this answer?
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Most Upvoted Answer
Which of the following statements is incorrect for sickle cell anaemia...
Incorrect Statement: Sixth amino acid (from NH2 terminus) of beta chain is glutamic acid.
There are several incorrect statements given, but we are specifically focusing on the incorrect statement regarding the sixth amino acid of the beta chain in sickle cell anaemia.
Explanation:
Sickle cell anaemia is an inherited blood disorder characterized by the presence of abnormal haemoglobin, known as haemoglobin S (HbS). This abnormal haemoglobin causes the red blood cells to become sickle-shaped and less flexible, leading to various complications.
Beta Chain of Haemoglobin in Sickle Cell Anaemia:
- Haemoglobin is composed of four protein chains, two alpha chains, and two beta chains.
- In sickle cell anaemia, a mutation occurs in the beta chain of haemoglobin.
- The mutation substitutes the amino acid valine for glutamic acid at the sixth position of the beta chain.
- This mutation is caused by a single nucleotide change in the DNA sequence, resulting in the substitution of adenine (A) with thymine (T) in the beta-globin gene.
- As a result, the codon GAG, which encodes glutamic acid, is changed to GTG, which encodes valine.
Consequences of the Mutation:
- The substitution of valine for glutamic acid alters the structural conformation of the beta chain.
- This leads to the formation of abnormal haemoglobin S, which tends to polymerize and form long, rigid chains when deoxygenated.
- These polymerized haemoglobin chains cause the red blood cells to deform and take on a sickle shape.
- The sickle-shaped cells are less flexible and can get stuck in small blood vessels, leading to vaso-occlusive episodes and tissue damage.
Summary:
The incorrect statement in question states that the sixth amino acid (from the NH2 terminus) of the beta chain in sickle cell anaemia is glutamic acid. However, in reality, the mutation in sickle cell anaemia substitutes this glutamic acid with valine. This mutation alters the structure of the beta chain and leads to the formation of abnormal haemoglobin S, resulting in the characteristic sickle-shaped red blood cells.
There are several incorrect statements given, but we are specifically focusing on the incorrect statement regarding the sixth amino acid of the beta chain in sickle cell anaemia.
Explanation:
Sickle cell anaemia is an inherited blood disorder characterized by the presence of abnormal haemoglobin, known as haemoglobin S (HbS). This abnormal haemoglobin causes the red blood cells to become sickle-shaped and less flexible, leading to various complications.
Beta Chain of Haemoglobin in Sickle Cell Anaemia:
- Haemoglobin is composed of four protein chains, two alpha chains, and two beta chains.
- In sickle cell anaemia, a mutation occurs in the beta chain of haemoglobin.
- The mutation substitutes the amino acid valine for glutamic acid at the sixth position of the beta chain.
- This mutation is caused by a single nucleotide change in the DNA sequence, resulting in the substitution of adenine (A) with thymine (T) in the beta-globin gene.
- As a result, the codon GAG, which encodes glutamic acid, is changed to GTG, which encodes valine.
Consequences of the Mutation:
- The substitution of valine for glutamic acid alters the structural conformation of the beta chain.
- This leads to the formation of abnormal haemoglobin S, which tends to polymerize and form long, rigid chains when deoxygenated.
- These polymerized haemoglobin chains cause the red blood cells to deform and take on a sickle shape.
- The sickle-shaped cells are less flexible and can get stuck in small blood vessels, leading to vaso-occlusive episodes and tissue damage.
Summary:
The incorrect statement in question states that the sixth amino acid (from the NH2 terminus) of the beta chain in sickle cell anaemia is glutamic acid. However, in reality, the mutation in sickle cell anaemia substitutes this glutamic acid with valine. This mutation alters the structure of the beta chain and leads to the formation of abnormal haemoglobin S, resulting in the characteristic sickle-shaped red blood cells.
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Community Answer
Which of the following statements is incorrect for sickle cell anaemia...
Except A other all options are correct...
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Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer?
Question Description
Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer? for NEET 2024 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer? covers all topics & solutions for NEET 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer?.
Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer? for NEET 2024 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer? covers all topics & solutions for NEET 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer?.
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Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer?, a detailed solution for Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer? has been provided alongside types of Which of the following statements is incorrect for sickle cell anaemia?a)Sixth amino acid (from NH2terminus) of beta chain is glutamic acid.b)Erythrocytes elongate and form sickle-shaped cells.c)Individual homozygous for haemoglobin S allele is Hbs/HIbs.d)Beta chain of haemoglobin S contains valine.Correct answer is option 'A'. Can you explain this answer? theory, EduRev gives you an
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