Metakelfin in the treatment of Malaria

Metakelfin, also known as Methylene blue, is a medication that has multiple uses, one of which is the treatment of malaria. Malaria is a life-threatening disease caused by the Plasmodium parasite, which is transmitted to humans through the bite of infected mosquitoes. It is prevalent in tropical and subtropical regions of the world.

Mechanism of action

Metakelfin works by interfering with the metabolism of the Plasmodium parasite. It inhibits the electron transport chain in the parasite's mitochondria, which is essential for its survival and replication. This disruption in energy production ultimately leads to the death of the parasite.

Effectiveness against malaria

Metakelfin has been found to be effective against multiple species of Plasmodium, including Plasmodium falciparum, which is the most dangerous species causing severe malaria. It is particularly useful in areas where Plasmodium falciparum has developed resistance to other antimalarial drugs, such as chloroquine.

Administration

Metakelfin can be administered orally or intravenously, depending on the severity of the malaria infection. It is usually given in combination with other antimalarial drugs to enhance its effectiveness and prevent the development of resistance.

Side effects

Common side effects of Metakelfin include nausea, vomiting, headache, dizziness, and a temporary blue or green discoloration of the urine or stool. These side effects are generally mild and resolve on their own. However, in rare cases, Metakelfin can cause more serious adverse effects, such as methemoglobinemia, a condition where the oxygen-carrying capacity of the blood is reduced.

Conclusion

Metakelfin is a valuable antimalarial medication that is used in the treatment of malaria, particularly when other drugs have failed or resistance is a concern. It works by disrupting the metabolism of the Plasmodium parasite, ultimately leading to its death. Although it has some side effects, they are generally tolerable and outweighed by the benefits of its antimalarial action.

It is used for the treatment of antimalarial agent prescribes for the treatment of falciparum malaria. resistant to chloroquine. So metakelfin used for malaria.
So option " C " is correct answer.