Atrial natriuretic factora)increases blood pressureb)decreases blood ...
The atrial natriuretic hormone (ANP) is a cardiac hormone in which genes and receptors are widely present in the body. Its main function is to lower blood pressure and to control electrolyte homeostasis. So the correct option is 'Increase blood pressure'.
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Atrial natriuretic factora)increases blood pressureb)decreases blood ...
Atrial natriuretic factor (ANF) is a hormone produced by the atria of the heart in response to increased blood pressure or volume. ANF acts to decrease blood pressure by promoting natriuresis, or the excretion of sodium and water in the urine.
Mechanism of action:
ANF binds to receptors on the surface of kidney cells, particularly in the renal tubules. This binding activates a signaling pathway that leads to increased excretion of sodium and water in the urine. This decreases the volume of blood in the circulatory system, leading to a decrease in blood pressure.
Effects on the circulatory system:
ANF also acts to dilate blood vessels, leading to increased blood flow and decreased resistance in the peripheral vasculature. This further decreases blood pressure. ANF also has an inhibitory effect on the renin-angiotensin-aldosterone system (RAAS), which is involved in the regulation of blood pressure. By inhibiting the RAAS, ANF helps to decrease blood pressure.
Clinical implications:
ANF has potential clinical applications in the treatment of hypertension and heart failure. Synthetic forms of ANF, such as Nesiritide, have been developed and are used in the treatment of acute decompensated heart failure. These drugs help to decrease blood pressure by promoting natriuresis and vasodilation.
In conclusion, ANF is a hormone produced by the heart in response to increased blood pressure or volume. ANF acts to decrease blood pressure by promoting natriuresis and vasodilation. Synthetic forms of ANF have potential clinical applications in the treatment of hypertension and heart failure.
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