Regulation of Sertoli cells by FSH

Sertoli cells are found in the testes of males and play a crucial role in sperm development and maturation. These cells are regulated by the pituitary gland through the release of follicle-stimulating hormone (FSH). Here's how FSH regulates Sertoli cells:

FSH production: FSH is produced by the anterior pituitary gland in response to gonadotropin-releasing hormone (GnRH) released by the hypothalamus.

Binding to receptors: FSH binds to specific receptors on the surface of Sertoli cells in the testes.

Stimulation of spermatogenesis: FSH stimulates Sertoli cells to produce androgen-binding protein (ABP), which binds to testosterone and keeps it within the seminiferous tubules where it is needed for spermatogenesis. FSH also stimulates the production of inhibin, which inhibits the secretion of FSH by the pituitary gland, resulting in negative feedback.

Regulation of Sertoli cell function: FSH plays a key role in regulating the function of Sertoli cells, including the secretion of nutrients and growth factors required for sperm development and maturation.

In summary, FSH is the primary hormone responsible for regulating Sertoli cell function in the testes. It stimulates the production of ABP and inhibin, regulates the secretion of nutrients and growth factors required for spermatogenesis, and is subject to negative feedback regulation.