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Osteoporosis, an age-related disease of skeletal system, may occur due to    [2016]
  • a)
    Immune disorder affecting neuromuscular junction leading to fatigue
  • b)
    High concentration of Ca++ and Na+ 
  • c)
    Decreased level of estrogen
  • d)
    Accumulation of uric acid leading to inflammation of joints.
Correct answer is option 'C'. Can you explain this answer?
Verified Answer
Osteoporosis, an age-related disease of skeletal system, may occur due...
Osteoporosis is reduction in bone mineral density, resulting in bones that are brittle and liable to fracture. Infection, injury and synovitis can cause localised osteoporosis of adjacent bone, Generalised osteoporosis is common in the elderly and in women after menopause. After menopause the estrogen levels in blood plasma are much reduced. Estrogen helps to regulate bone cells called osteoclasts which are responsible for building new bone. When estrogen levels drop fewer osteoclasts are produced resulting in osteoporosis.
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Most Upvoted Answer
Osteoporosis, an age-related disease of skeletal system, may occur due...
Understanding Osteoporosis
Osteoporosis is a progressive skeletal disorder characterized by decreased bone density and increased fragility, leading to a higher risk of fractures. It is particularly common in older adults, especially postmenopausal women.
Role of Estrogen
- Estrogen is a key hormone that helps maintain bone density.
- It inhibits the activity of osteoclasts, the cells responsible for bone resorption.
- A decrease in estrogen levels, especially during menopause, leads to increased bone resorption and decreased bone formation.
Why Option C is Correct
- The correct answer is option 'C', which states that osteoporosis may occur due to decreased levels of estrogen.
- This hormonal change accelerates bone loss, making bones weaker and more susceptible to fractures.
Other Options Explained
- Option A: Immune disorder affecting the neuromuscular junction leading to fatigue does not directly relate to bone density issues.
- Option B: High concentrations of Ca++ and Na+ can affect various physiological processes but are not directly responsible for osteoporosis.
- Option D: Accumulation of uric acid leading to joint inflammation is associated with gout, not osteoporosis.
Conclusion
Understanding the hormonal influences on bone health is critical for preventing and managing osteoporosis. The decline in estrogen levels is a primary risk factor, making awareness and timely intervention essential, especially for postmenopausal women.
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Osteoporosis, an age-related disease of skeletal system, may occur due to [2016]a)Immune disorder affecting neuromuscular junction leading to fatigueb)High concentration of Ca++and Na+c)Decreased level of estrogend)Accumulation of uric acid leading to inflammation of joints.Correct answer is option 'C'. Can you explain this answer?
Question Description
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