Which of the following factors is responsible for the formation of con...
The counter current mechanism helps to maintain a concentration gradient in the medullary mterstitium. The proximity between the Henle’s loop and vasa recta, as well as the counter current in them help in maintaining an increasing osmolarity towards the inner medullary interstitium, i.e., from 300 mOsmoIL-1 in the cortex to about 1200 mOsmolL-1 m the inner medulla. This gradient is mainly caused by NaCl and urea. Presence of such interstitial gradient helps in an easy passage of water from the collecting tubule thereby concentrating the filtrate (urine).
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Which of the following factors is responsible for the formation of con...
Concentration of urine in the kidneys
Maintaining hyperosmolarity towards the medullary interstitium in the kidneys is responsible for the formation of concentrated urine. This process involves several key factors working together to ensure the urine is concentrated.
Countercurrent mechanism
- The countercurrent mechanism in the nephron of the kidney plays a crucial role in concentrating urine. The loop of Henle creates a concentration gradient in the medulla by allowing the reabsorption of water and solutes.
Antidiuretic hormone (ADH)
- ADH, also known as vasopressin, is a hormone that regulates the reabsorption of water in the kidneys. When ADH levels are high, more water is reabsorbed from the collecting ducts, leading to concentrated urine.
Osmolarity of the medullary interstitium
- The high osmolarity of the medullary interstitium is essential for the reabsorption of water from the collecting ducts. This osmolarity gradient is maintained by the countercurrent mechanism in the loop of Henle.
Role of collecting ducts
- The collecting ducts play a critical role in concentrating urine by reabsorbing water based on the osmotic gradient established in the medulla. This reabsorption is regulated by ADH.
By maintaining hyperosmolarity towards the medullary interstitium in the kidneys, the body can produce concentrated urine, which helps in conserving water and maintaining proper fluid balance.