Podocytes are the cells present ona)outer wall of Bowmans capsuleb)inner wall of bowmans capsulec)neck of nephrond)wall of glomerular capillariesCorrect answer is option 'B'. Can you explain this answer?

Question

Answer

Podocytes are the special type of cells present in the visceral layer of Bowman's capsule. These cells have foot like processes called pedicels. The space between the pedicels are called slit pores through which the glomerular filtrate filters.

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Answer

Podocytes are the cells present on the inner wall of Bowman's capsule.

Introduction:
The nephron is the functional unit of the kidney, responsible for the filtration, reabsorption, and secretion of substances. Bowman's capsule is the initial part of the nephron and is involved in the filtration of blood to form urine. Podocytes are specialized cells that play a crucial role in the filtration process within Bowman's capsule.

Location:
Podocytes are found on the inner wall of Bowman's capsule, which is the cup-shaped structure that surrounds the glomerulus. The glomerulus is a network of tiny blood vessels called glomerular capillaries.

Structure and Function:
Podocytes have unique cellular extensions called foot processes, which interdigitate and wrap around the glomerular capillaries. These foot processes form a filtration barrier known as the slit diaphragm, which prevents the passage of large molecules such as proteins while allowing the filtration of smaller molecules like water, ions, and waste products. The filtration barrier formed by podocytes and the capillary endothelial cells is known as the glomerular filtration barrier.

Role in Filtration:
The podocytes, with their foot processes and the slit diaphragm, contribute to the selective filtration of substances in the glomerulus. The filtration process begins with blood entering the glomerular capillaries under high pressure. As blood flows through the capillaries, small molecules and fluid are filtered out into the Bowman's capsule, forming the glomerular filtrate.

The foot processes of podocytes wrap around the capillaries, creating filtration slits. These slits are covered by the slit diaphragm, which acts as a size-selective barrier. The size and charge of molecules determine their ability to pass through the filtration barrier. Small molecules like water, ions, and waste products can pass through the filtration slits, while larger molecules like proteins are retained in the blood.

Conclusion:
In summary, podocytes are specialized cells found on the inner wall of Bowman's capsule. They play a crucial role in the filtration of blood in the glomerulus by forming a filtration barrier with their foot processes and slit diaphragm. The selective filtration by podocytes allows smaller molecules to pass through while preventing the filtration of larger molecules like proteins.

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