Feedback Inhibition of Enzyme
Feedback inhibition is a regulatory mechanism in which the end product of a metabolic pathway inhibits an enzyme involved in the pathway. This helps to prevent the overproduction of a particular product and maintain homeostasis within the cell.

Factors influencing feedback inhibition
- End product: The key factor influencing feedback inhibition is the end product of a metabolic pathway. When the concentration of the end product reaches a certain level, it binds to the enzyme responsible for its production, inhibiting its activity. This allows the cell to regulate the amount of product produced based on its needs.
- Enzyme: The enzyme involved in the metabolic pathway plays a crucial role in feedback inhibition. It must have a binding site for the end product to allow for inhibition to occur. The specificity of the enzyme for its end product determines the effectiveness of feedback inhibition.
- Substrate: While the substrate also plays a role in enzyme activity, it is not directly involved in feedback inhibition. Substrate availability can influence the rate of enzymatic reactions, but feedback inhibition is primarily controlled by the end product.
- External factors: External factors such as pH, temperature, and cofactors can affect enzyme activity, but they do not directly influence feedback inhibition. These factors can impact the overall function of the enzyme but do not specifically regulate feedback inhibition.
In conclusion, feedback inhibition of enzymes is primarily influenced by the end product of a metabolic pathway. Understanding this regulatory mechanism is crucial for maintaining metabolic balance and ensuring the efficient use of resources within the cell.