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Michaelis Menten Constant (Km​) is equal to
  • a)
    The rate of reaction
  • b)
    The rate of enzymatic activity
  • c)
    Substrate concentration at which the reaction attains half of its maximum velocity
  • d)
    Substrate concentration at which the rate of reaction is maximum
Correct answer is option 'C'. Can you explain this answer?
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Michaelis Menten Constant(Km)is equal toa)The rate of reactionb)The ra...
Km  or the Michaelis-Menten constant is defined as the substrate concentration (expressed in moles/l) at which half-maximum velocity in an enzyme catalysed reaction is achieved. It indicates that half of the enzyme molecules (i.e. 50%) are bound with the substrate molecules when the substrate concentration equals the Km value. It was given by Leonor Michaelis and Maud Menten (1913). Km value is a characteristic feature of a given enzyme. It is a representative for measuring the strength of ES complex. A low Km value indicates a strong affinity between enzyme and substrate, whereas a high Km value reflects a weak affinity between them. For majority of enzymes, the Km values are in the range of 10−5 to 10−2 moles.
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Michaelis Menten Constant(Km)is equal toa)The rate of reactionb)The ra...
Substrate concentration at which the reaction attains half of its maximum velocity

The Michaelis-Menten constant (Km) is a parameter used in enzyme kinetics to describe the affinity of an enzyme for its substrate. It is defined as the substrate concentration at which the reaction rate is half of its maximum velocity.

Enzyme Kinetics
Enzyme kinetics is the study of the rates at which enzymes catalyze chemical reactions. It involves the measurement of reaction rates under different conditions, including varying substrate concentrations.

Michaelis-Menten Equation
The Michaelis-Menten equation is a mathematical model that describes the relationship between the rate of an enzyme-catalyzed reaction and the substrate concentration. It is given by the equation:

v = (Vmax * [S]) / (Km + [S])

Where:
- v is the reaction rate or velocity
- Vmax is the maximum velocity of the reaction
- [S] is the substrate concentration
- Km is the Michaelis-Menten constant

Interpreting Km
The Michaelis-Menten constant (Km) is a measure of the affinity of the enzyme for its substrate. It represents the substrate concentration at which the reaction rate is half of its maximum velocity.

When the substrate concentration is below Km, the rate of the reaction is relatively slow because there is not enough substrate available to saturate the enzyme. As the substrate concentration increases and approaches Km, the rate of the reaction increases.

Once the substrate concentration exceeds Km, the rate of the reaction reaches its maximum velocity (Vmax). At this point, the enzyme is saturated with substrate and all active sites are occupied. Further increases in substrate concentration will not increase the rate of the reaction.

Therefore, the correct answer is option C: Km represents the substrate concentration at which the reaction attains half of its maximum velocity.
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Read the passage given below and answer the following questions:The rate of a reaction, which may also be called its velocity or speed, can be defined with relation to the concentration of any of the reacting substances, or to that of any product of the reaction. If the species chosen is a reactant which has a concentration c at time t the rate is - dc/dt, while the rate with reference to a product having a concentration x at time t is dx/dt. Any concentration units may be used for expressing the rate; thus, if moles per liter are employed for concentration and seconds for the time, the units for the rate are moles litre–1sec–1. For gas reactions pressure units are sometimes used in place of concentrations, so that legitimate units for the rate would be (mm. Hg) sec–1 and atm. sec–1 The order of a reaction concerns the dependence of the rate upon the concentrations of reacting substances; thus, if the rate is found experimentally to be proportional to the ath power of the concentration of one of the reactants A, to the both power of the concentration of a second reactant B, and so forth, via., rate = k CAα CAβ the over-all order of the reaction is simply n = α + β + ----- (2) Such a reaction is said to be of the αth order with respect to the substance A, the βth order with respect to B.In the following questions, a statement of Assertion followed by a statement of Reason is given. Choose the correct answer out of the following choices on the basis of the above passage.Assertion: Rate of reaction is a measure of change in concentration of reactant with respect to time.Reason: Rate of reaction is a measure of change in concentration of product with respect to time.

Read the passage given below and answer the following questions:The rate of a reaction, which may also be called its velocity or speed, can be defined with relation to the concentration of any of the reacting substances, or to that of any product of the reaction. If the species chosen is a reactant which has a concentration c at time t the rate is - dc/dt, while the rate with reference to a product having a concentration x at time t is dx/dt. Any concentration units may be used for expressing the rate; thus, if moles per liter are employed for concentration and seconds for the time, the units for the rate are moles litre–1sec–1. For gas reactions pressure units are sometimes used in place of concentrations, so that legitimate units for the rate would be (mm. Hg) sec–1 and atm. sec–1 The order of a reaction concerns the dependence of the rate upon the concentrations of reacting substances; thus, if the rate is found experimentally to be proportional to the ath power of the concentration of one of the reactants A, to the both power of the concentration of a second reactant B, and so forth, via., rate = k CAα CAβ the over-all order of the reaction is simply n = α + β + ----- (2) Such a reaction is said to be of the αth order with respect to the substance A, the βth order with respect to B.In the following questions, a statement of Assertion followed by a statement of Reason is given. Choose the correct answer out of the following choices on the basis of the above passage.Assertion: The unit of k is independent of order of reaction.Reason: The unit of k is moles L–1s–1.

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Michaelis Menten Constant(Km)is equal toa)The rate of reactionb)The rate of enzymatic activityc)Substrate concentration at which the reaction attains half of its maximum velocityd)Substrate concentration at which the rate of reaction is maximumCorrect answer is option 'C'. Can you explain this answer?
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